2018
Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age
Kuban K, Heeren T, O'Shea T, Joseph R, Fichorova R, Douglass L, Jara H, Frazier J, Hirtz D, Taylor H, Rollins J, Paneth N, Investigators E, Ware J, Coster T, Hanson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Shah B, Singh R, Smith A, Klein D, McQuiston S, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K, Yamamoto H, Ryan S, Junaid D, Dawood H, Beatty N, Luu N, Tang V, Sassi R, Pasicznyk J. Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age. The Journal Of Pediatrics 2018, 201: 40-48.e4. PMID: 30029870, PMCID: PMC6684153, DOI: 10.1016/j.jpeds.2018.05.021.Peer-Reviewed Original ResearchConceptsWeeks of lifeNeurotrophic proteinsSevere cognitive impairmentBlood levelsCognitive impairmentInflammatory proteinLower riskBrain-derived neurotrophic factorNeonatal blood specimensProtein blood levelsHigh blood levelsAdverse cognitive outcomesElevated blood levelsLow Gestational Age Newborn StudyNormal T cellsYears of ageHigh exposureFunction testsNeurotrophic factorCognitive function levelT cellsReduced riskMultinomial logistic regressionElevated proteinBlood specimens
2016
Non‐ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study
Charman T, Young GS, Brian J, Carter A, Carver LJ, Chawarska K, Curtin S, Dobkins K, Elsabbagh M, Georgiades S, Hertz‐Picciotto I, Hutman T, Iverson JM, Jones EJ, Landa R, Macari S, Messinger DS, Nelson CA, Ozonoff S, Saulnier C, Stone WL, Tager‐Flusberg H, Webb SJ, Yirmiya N, Zwaigenbaum L. Non‐ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Research 2016, 10: 169-178. PMID: 27417857, PMCID: PMC5993543, DOI: 10.1002/aur.1669.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleAutism spectrum disorderHigh-risk siblingsLow-risk controlsBroader autism phenotypeModerate language delayAdaptive functioningASD symptomsLanguage delayVineland Adaptive Behavior ScalesLower adaptive functioningAge 3 yearsAutism Diagnostic InterviewProportion of toddlersAdaptive behavior outcomesAdaptive Behavior ScalesOngoing clinical monitoringAutism phenotypeMullen ScalesSpectrum disorderObservation ScheduleEarly learningBehavioral outcomesElevated scoresDevelopmental outcomes
2015
Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study
Ozonoff S, Young GS, Landa RJ, Brian J, Bryson S, Charman T, Chawarska K, Macari SL, Messinger D, Stone WL, Zwaigenbaum L, Iosif AM. Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study. Journal Of Child Psychology And Psychiatry 2015, 56: 988-998. PMID: 25921776, PMCID: PMC4532646, DOI: 10.1111/jcpp.12421.Peer-Reviewed Original ResearchConceptsMonths of ageCommunity-ascertained sampleAutism spectrum disorderHigh-risk groupYoung childrenASD diagnosisAge 3Public health implicationsSample of infantsSpectrum disorderDiagnostic criteriaDiagnostic stabilityIntensive surveillanceSiblings of childrenAmerican AcademyEarly identificationClinical diagnosisConsortium studyFamilial riskEarly signsDiagnosisMonthsFamilial factorsASD outcomeInitial assessment
2014
18-Month Predictors of Later Outcomes in Younger Siblings of Children With Autism Spectrum Disorder: A Baby Siblings Research Consortium Study
Chawarska K, Shic F, Macari S, Campbell DJ, Brian J, Landa R, Hutman T, Nelson CA, Ozonoff S, Tager-Flusberg H, Young GS, Zwaigenbaum L, Cohen IL, Charman T, Messinger DS, Klin A, Johnson S, Bryson S. 18-Month Predictors of Later Outcomes in Younger Siblings of Children With Autism Spectrum Disorder: A Baby Siblings Research Consortium Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2014, 53: 1317-1327.e1. PMID: 25457930, PMCID: PMC4254798, DOI: 10.1016/j.jaac.2014.09.015.Peer-Reviewed Original ResearchConceptsPoor eye contactHigh riskEarly diagnostic considerationAutism spectrum disorderAge 3 yearsEye contactBaby Siblings Research Consortium StudyClinical featuresDiagnostic considerationsSpectrum disorderSpecific treatmentYounger siblingsSymptom profilesAutism Diagnostic Observation ScheduleConsortium studyMonthsDiagnostic outcomesRegression tree analysisOutcomesLater OutcomesChildrenDevelopmental outcomesHigh functioningSiblingsBehavioral profile