2007
Breast Cancer–Associated Gene 3 (BCA3) Is a Novel Rac1‐Interacting Protein*
Yu K, Itokawa T, Zhu M, Syam S, Seth A, Insogna K. Breast Cancer–Associated Gene 3 (BCA3) Is a Novel Rac1‐Interacting Protein*. Journal Of Bone And Mineral Research 2007, 22: 628-637. PMID: 17227220, DOI: 10.1359/jbmr.070105.Peer-Reviewed Original Research
1991
Immunoaffinity purification of parathyroid hormone‐related protein from bovine milk and human keratinocyte‐conditioned medium
Stewart A, Wu T, Insogna K, Milstone L, Burtis W. Immunoaffinity purification of parathyroid hormone‐related protein from bovine milk and human keratinocyte‐conditioned medium. Journal Of Bone And Mineral Research 1991, 6: 305-311. PMID: 2035357, DOI: 10.1002/jbmr.5650060313.Peer-Reviewed Original Research
1990
Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase
Brown G, Morris C, Mitnick M, Insogna K. Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase. Journal Of Bone And Mineral Research 1990, 5: 1037-1041. PMID: 1964358, DOI: 10.1002/jbmr.5650051007.Peer-Reviewed Original ResearchConceptsSerum calciumBone resorptionHumoral hypercalcemiaCarbonic anhydrase inhibitorsNephrogenous cyclic AMP excretionCyclic AMP excretionMean serum calciumOsteoclastic bone resorptionDrug-treated animalsLeydig cell tumorMechanism of actionUrine phosphorusUrine calciumSerum phosphorusCell tumorsAcetazolamide treatmentHypercalcemiaSignificant fallFisher ratsObserved hypercalcemiaResorptionDirect inhibitionSignificant riseMalignancyRats
1989
Humoral Hypercalcemia of Malignancy: The Role of Parathyroid Hormone-related Protein
Insogna K. Humoral Hypercalcemia of Malignancy: The Role of Parathyroid Hormone-related Protein. Endocrinology And Metabolism Clinics Of North America 1989, 18: 779-794. PMID: 2673773, DOI: 10.1016/s0889-8529(18)30366-9.BooksConceptsMalignancy-associated hypercalcemiaHumoral hypercalcemiaRenal tubular calcium reabsorptionParathyroid hormone-related proteinIntense bone resorptionTubular calcium reabsorptionTumor-derived factorsCentral pathogenic roleHormone-related proteinTumor-derived tissueCalcium reabsorptionBone resorptionPathogenic roleCommon causeHypercalcemiaExperimental modelHHMDevelopment of antiseraMalignancyPTHrPAnalysis of mRNAAntiserumPreliminary studySyndromeAmino-terminal polypeptideParathyroid Hormone-Related Protein Modulates the Effect of Transforming Growth Factor-β on Deoxyribonucleic Acid and Collagen Synthesis in Fetal Rat Bone Cells*
CENTRELLA M, CANALIS E, MCCARTHY TL, STEWART AF, ORLOFF JJ, INSOGNA KL. Parathyroid Hormone-Related Protein Modulates the Effect of Transforming Growth Factor-β on Deoxyribonucleic Acid and Collagen Synthesis in Fetal Rat Bone Cells*. Endocrinology 1989, 125: 199-208. PMID: 2737143, DOI: 10.1210/endo-125-1-199.Peer-Reviewed Original ResearchNative and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties.
Insogna KL, Stewart AF, Morris CA, Hough LM, Milstone LM, Centrella M. Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties. Journal Of Clinical Investigation 1989, 83: 1057-1060. PMID: 2537846, PMCID: PMC303783, DOI: 10.1172/jci113947.Peer-Reviewed Original ResearchConceptsGrowth factor-like propertiesParathyroid hormone-like proteinHormone-like proteinNRK-49F cellsParaneoplastic syndromeHumoral hypercalcemiaLatter hormoneHuman tumorsPhysiological actionsPTHHuman dermal fibroblastsSignificant increaseSoft agarDisplay actionsDermal fibroblastsSynthetic peptidesSynthetic analoguesHypercalcemiaMalignancySyndromeTumorsUnique primary structureSynthesis of a Gene Encoding Parathyroid Hormone-Like Protein-(1–141): Purification and Biological Characterization of the Expressed Protein*
THORIKAY M, KRAMER S, REYNOLDS F, SORVILLO J, DOESCHER L, WU T, MORRIS C, BURTIS W, INSOGNA K, VALENZUELA D, STEWART A. Synthesis of a Gene Encoding Parathyroid Hormone-Like Protein-(1–141): Purification and Biological Characterization of the Expressed Protein*. Endocrinology 1989, 124: 111-118. PMID: 2535801, DOI: 10.1210/endo-124-1-111.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBiological AssayBone and BonesCalciumCloning, MolecularCyclic AMPDNADogsEscherichia coliGenes, SyntheticKidneyMolecular Sequence DataMolecular WeightNeoplasm ProteinsOsteosarcomaParathyroid HormoneParathyroid Hormone-Related ProteinPeptide FragmentsPlasmidsRatsRecombinant ProteinsTumor Cells, Cultured
1988
Isolation of 16,000-Dalton Parathyroid Hormone-Like Proteins from Two Animal Tumors Causing Humoral Hypercalcemia of Malignancy*
Weir EC, Burtis WJ, Morris CA, Brady TG, Insogna KL. Isolation of 16,000-Dalton Parathyroid Hormone-Like Proteins from Two Animal Tumors Causing Humoral Hypercalcemia of Malignancy*. Endocrinology 1988, 123: 2744-2751. PMID: 3197642, DOI: 10.1210/endo-123-6-2744.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAmino Acid SequenceAmino AcidsAnimalsDogsHumansHypercalcemiaLeydig Cell TumorMaleMolecular Sequence DataMolecular WeightNeoplasm ProteinsNeoplasmsParathyroid Hormone-Related ProteinRatsRats, Inbred F344Sequence Homology, Nucleic AcidSweat Gland NeoplasmsTesticular NeoplasmsConceptsPTH-like proteinAnimal tumorsPTH-like peptideHumoral hypercalcemiaParathyroid hormone-like proteinSynthetic human PTHLeydig cell tumorHuman PTH-like peptideHormone-like proteinTransplantable animal tumorsCell adenocarcinomaCanine proteinCell tumorsResponsible mediatorsHuman PTHImmunoradiometric assayTumorsHuman tumorsAdenylate cyclaseLike peptidesAnal sacHypercalcemiaBone cellsMalignancyPotent activatorCharacterization of a parathyroid Hormonelike Peptide Secreted by Human Keratinocytes
INSOGNA K, STWART A, IKEDA K, CENTRELLA M, MILSONE L. Characterization of a parathyroid Hormonelike Peptide Secreted by Human Keratinocytes. Annals Of The New York Academy Of Sciences 1988, 548: 146-159. PMID: 2470290, DOI: 10.1111/j.1749-6632.1988.tb18801.x.Peer-Reviewed Original ResearchHumoral Hypercalcemia of Cancer
Flier J, Underhill L, Broadus A, Mangin M, Ikeda K, Insogna K, Weir E, Burtis W, Stewart A. Humoral Hypercalcemia of Cancer. New England Journal Of Medicine 1988, 319: 556-563. PMID: 3043221, DOI: 10.1056/nejm198809013190906.BooksIdentification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy.
Ikeda K, Mangin M, Dreyer BE, Webb AC, Posillico JT, Stewart AF, Bander NH, Weir EC, Insogna KL, Broadus AE. Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. Journal Of Clinical Investigation 1988, 81: 2010-2014. PMID: 2454953, PMCID: PMC442656, DOI: 10.1172/jci113551.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCloning, MolecularHumansHypercalcemiaKidney NeoplasmsMolecular Sequence DataNeoplasm ProteinsNucleic Acid HybridizationParaneoplastic SyndromesParathyroid HormoneParathyroid Hormone-Related ProteinPoly ARNARNA, MessengerRNA, NeoplasmSequence Homology, Nucleic AcidTranscription, GeneticConceptsPTH-like peptideParathyroid hormone-like peptideAnimal tumorsHumoral hypercalcemiaHormone-like peptideSyndrome of HHMVariety of humanHuman PTH-like peptideSimilar histological typeHistological typeHuman PTHTumor typesTumorsHHMHypercalcemiaMalignancySyndromeMessenger RNAMRNAWide spectrumHumansPeptidesMammalian speciesRNAPTHHumoral hypercalcemia of malignancy.
Burtis WJ, Wu TL, Insogna KL, Stewart AF. Humoral hypercalcemia of malignancy. Annals Of Internal Medicine 1988, 108: 454-7. PMID: 3277518, DOI: 10.7326/0003-4819-108-3-454.BooksSynthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.
Stewart AF, Mangin M, Wu T, Goumas D, Insogna KL, Burtis WJ, Broadus AE. Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. Journal Of Clinical Investigation 1988, 81: 596-600. PMID: 3339131, PMCID: PMC329608, DOI: 10.1172/jci113358.Peer-Reviewed Original ResearchConceptsBone-resorbing agentsMicrograms/hParathyroid hormone-like proteinFetal rat long bonesAdenylate cyclasePotent bone-resorbing agentHormone-like proteinRat long bonesMembrane adenylate cyclaseSerum calciumHumoral hypercalcemiaOsmotic minipumpsBone resorptionPotent agonistLong bonesSuch synthetic peptidesHypercalcemiaRatsDlVivo bioactivityCyclaseSynthetic peptidesAgentsMinipumpsPatients
1987
Skin-Derived Fibroblasts Respond to Human Parathyroid Hormone-Like Adenylate Cyclase-Stimulating Proteins*
WU T, INSOGNA K, HOUGH L, MILSTONE L, STEWART A. Skin-Derived Fibroblasts Respond to Human Parathyroid Hormone-Like Adenylate Cyclase-Stimulating Proteins*. The Journal Of Clinical Endocrinology & Metabolism 1987, 65: 105-109. PMID: 3034948, DOI: 10.1210/jcem-65-1-105.Peer-Reviewed Original ResearchConceptsPTH-like factorHumoral hypercalcemiaPTH analogsPTH-responsive adenylate cyclaseDermal fibroblast linesAdenylate cyclaseTumor-derived factorsAdenylate cyclase responseDermal fibroblastsAdenylate cyclase stimulationHuman dermal fibroblastsM bovine PTHDermal physiologyFibroblast linesHuman dermal fibroblast linesBovine PTHHigh prevalenceTumor extractsCyclase responseSkin-derived fibroblastsCyclase stimulationPTHKeratinocyte-conditioned mediumHuman tumorsApparent potency
1986
Two Species of Adenylate Cyclase-Stimulating Activity in a Murine Squamous Carcinoma Model of Humoral Hypercalcemia of Malignancy*
BURTIS W, BROADUS A, INSOGNA K, WEIR E, STEWART A. Two Species of Adenylate Cyclase-Stimulating Activity in a Murine Squamous Carcinoma Model of Humoral Hypercalcemia of Malignancy*. Endocrinology 1986, 118: 1982-1988. PMID: 3009144, DOI: 10.1210/endo-118-5-1982.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAnimalsBiological AssayCarcinoma, Squamous CellChromatography, High Pressure LiquidDisease Models, AnimalDogsHypercalcemiaKidney CortexMiceNeoplasm ProteinsOsteosarcomaParathyroid HormonePeptide FragmentsRatsReceptors, Cell SurfaceReceptors, Parathyroid HormoneSkin NeoplasmsConceptsAdenylate cyclase-stimulating activityCyclase-stimulating activityTumor extractsPTH antagonistHumoral hypercalcemiaRat osteosarcomaCarcinoma modelDose-response curve parallelRat Leydig cellsAdenylate cyclase activityAdenylate cyclase systemDose-response curvePostreceptor stepPTH (3-34) amideLeydig cellsReversed-phase HPLCCyclase systemCyclase activityPeak IICommon mediatorPTHCyclase assaysHypercalcemiaMalignancyPhase HPLCFrequency and partial characterization of adenylate cyclase‐stimulating activity in tumors associated with humoral hypercalcemia of malignancy
Stewart A, Insogna K, Burtis W, Aminiafshar A, Wu T, Weir E, Broadus A. Frequency and partial characterization of adenylate cyclase‐stimulating activity in tumors associated with humoral hypercalcemia of malignancy. Journal Of Bone And Mineral Research 1986, 1: 267-276. PMID: 2845726, DOI: 10.1002/jbmr.5650010305.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityCyclase-stimulating activityHumoral hypercalcemiaTumor extractsSyndrome of HHMBone-resorbing activityNonmalignant tissue samplesControl tumorsHumoral factorsControl groupTumorsTissue samplesHypercalcemiaPatientsMalignancyTissue culture mediumHigh-performance liquid chromatographyHHMLarge groupCulture mediumLiquid chromatographyGroupSyndromeActivityNephrogenous Cyclic AMP, Adenylate Cyclase-Stimulating Activity, and the Humoral Hypercalcemia of Malignancy
GODSALL JW, BURTIS WJ, INSOGNA KL, BROADUS AE, STEWART AF. Nephrogenous Cyclic AMP, Adenylate Cyclase-Stimulating Activity, and the Humoral Hypercalcemia of Malignancy. 1986, 42: 705-750. PMID: 3016837, DOI: 10.1016/b978-0-12-571142-5.50021-5.BooksConceptsNephrogenous cyclic AMPCyclase-stimulating activityUcAMP excretionHumoral hypercalcemiaLocal osteolytic hypercalcemiaAdenylate cyclase-stimulating activityBone-resorbing activityCyclic AMPHPT groupNcAMP excretionNormocalcemic patientsPathophysiologic syndromeTumor extractsAnimal modelsHypercalcemiaAnimal tumorsTumorsNcAMPHHMExcretionPatientsMalignancyObserved elevationBasic proteinAMP