1989
Humoral Hypercalcemia of Malignancy: The Role of Parathyroid Hormone-related Protein
Insogna K. Humoral Hypercalcemia of Malignancy: The Role of Parathyroid Hormone-related Protein. Endocrinology And Metabolism Clinics Of North America 1989, 18: 779-794. PMID: 2673773, DOI: 10.1016/s0889-8529(18)30366-9.BooksConceptsMalignancy-associated hypercalcemiaHumoral hypercalcemiaRenal tubular calcium reabsorptionParathyroid hormone-related proteinIntense bone resorptionTubular calcium reabsorptionTumor-derived factorsCentral pathogenic roleHormone-related proteinTumor-derived tissueCalcium reabsorptionBone resorptionPathogenic roleCommon causeHypercalcemiaExperimental modelHHMDevelopment of antiseraMalignancyPTHrPAnalysis of mRNAAntiserumPreliminary studySyndromeAmino-terminal polypeptide
1987
Skin-Derived Fibroblasts Respond to Human Parathyroid Hormone-Like Adenylate Cyclase-Stimulating Proteins*
WU T, INSOGNA K, HOUGH L, MILSTONE L, STEWART A. Skin-Derived Fibroblasts Respond to Human Parathyroid Hormone-Like Adenylate Cyclase-Stimulating Proteins*. The Journal Of Clinical Endocrinology & Metabolism 1987, 65: 105-109. PMID: 3034948, DOI: 10.1210/jcem-65-1-105.Peer-Reviewed Original ResearchConceptsPTH-like factorHumoral hypercalcemiaPTH analogsPTH-responsive adenylate cyclaseDermal fibroblast linesAdenylate cyclaseTumor-derived factorsAdenylate cyclase responseDermal fibroblastsAdenylate cyclase stimulationHuman dermal fibroblastsM bovine PTHDermal physiologyFibroblast linesHuman dermal fibroblast linesBovine PTHHigh prevalenceTumor extractsCyclase responseSkin-derived fibroblastsCyclase stimulationPTHKeratinocyte-conditioned mediumHuman tumorsApparent potency