1992
Parathyroid hormone‐related protein stimulates prostaglandin E2 release from human osteoblast‐like cells: Modulating effect of peptide length
Mitnick M, Isales C, Paliwal I, Insogna K. Parathyroid hormone‐related protein stimulates prostaglandin E2 release from human osteoblast‐like cells: Modulating effect of peptide length. Journal Of Bone And Mineral Research 1992, 7: 887-896. PMID: 1332431, DOI: 10.1002/jbmr.5650070805.Peer-Reviewed Original ResearchConceptsCyclic AMP accumulationPGE2 releaseAMP accumulationCultured fetal rat long bonesFetal rat long bonesSaos-2 cellsBone resorptive actionProstaglandin E2 secretionBone-active cytokineHormone-related proteinPrimary human bone cell culturesRelease of PGE2Prostaglandin E2 releaseEffects of PTHrPRat long bonesForm of PTHrPHuman osteoblast-like cellsMalignancy syndromeE2 secretionHumoral hypercalcemiaBasal secretionPGE2 secretionE2 releaseOsteoblast-like cellsPTHrP
1983
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Rodan SB, Insogna KL, Vignery AM, Stewart AF, Broadus AE, D'Souza SM, Bertolini DR, Mundy GR, Rodan GA. Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. Journal Of Clinical Investigation 1983, 72: 1511-1515. PMID: 6685137, PMCID: PMC370436, DOI: 10.1172/jci111108.Peer-Reviewed Original ResearchConceptsHumoral hypercalcemiaAdenylate cyclaseBone resorbing activityBone resorptive activityLeydig cell tumorCyclic AMP accumulationHuman prostate carcinomaRat Leydig cell tumorAdenylate cyclase stimulationSolid human tumorsNormocalcemic patientsOsteoblastic cellsResorbing activityCell tumorsLung adenocarcinomaProstate carcinomaROS 17/2.8 cellsAMP accumulationResorptive activityCyclase stimulationTumorsHuman tumorsStimulationHypercalcemiaRat carcinosarcoma