2002
Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status
Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP. Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Kidney International 2002, 62: 2109-2117. PMID: 12427135, DOI: 10.1046/j.1523-1755.2002.00671.x.Peer-Reviewed Original ResearchConceptsPendrin-positive cellsAcid-base statusPositive cellsBicarbonate secretionMouse kidneyAcid-base transportKnockout mouse modelProtein expression levelsMetabolic alkalosisDeficient dietExchanger pendrinPendrin expressionMouse modelSensorineural deafnessThyroid glandBicarbonate loadPendred syndromeWestern blottingApical membraneInner earPendrin proteinControl levelsKidneyPendrinProtein levels
2001
Mutations in the Na-Cl Cotransporter Reduce Blood Pressure in Humans
Cruz D, Simon D, Nelson-Williams C, Farhi A, Finberg K, Burleson L, Gill J, Lifton R. Mutations in the Na-Cl Cotransporter Reduce Blood Pressure in Humans. Hypertension 2001, 37: 1458-1464. PMID: 11408395, DOI: 10.1161/01.hyp.37.6.1458.Peer-Reviewed Original ResearchConceptsLower blood pressureBlood pressureGitelman syndromeHypokalemic alkalosisReduces Blood PressureHigh salt intakeReduced blood pressureDiastolic blood pressureHigh blood pressureWild-type subjectsNa-Cl cotransporterFamily membersSalt intakeRenal saltClinical consequencesEpidemiological studiesGeneral populationHeterozygous childrenSyndromeHeterozygote subjectsGenetic testingLower ageSalt homeostasisSignificant predictorsHypertension