2024
Association of Irritability with Restricted, Repetitive Behaviors and Social Communication Challenges in Autistic Youth
Menezes M, Rutten M, Anderson S, Linde J, Ibrahim K, Sukhodolsky D. Association of Irritability with Restricted, Repetitive Behaviors and Social Communication Challenges in Autistic Youth. Journal Of Autism And Developmental Disorders 2024, 1-8. PMID: 39141271, DOI: 10.1007/s10803-024-06505-0.Peer-Reviewed Original ResearchSocial communication challengesRestricted/repetitive behaviorsAutistic youthSocial communicationRepetitive behaviorsAutism characteristicsAffective Reactivity IndexAssociations of irritabilitySelf-injurious behaviorSocial Responsiveness ScaleHierarchical multiple regressionMental health concernsAssociated with several categoriesCompulsive behaviorsStereotyped behaviorExamined relationsRitualistic behaviorRestrictive behaviorsSame behaviorSocial motivationResponse scaleAutistic childrenInteraction challengesReactivity indexClinical research program89. Shared Disruptions in Neural Circuits of Eye Gaze Processing in Autism Spectrum Disorder and Schizophrenia
Ibrahim K, Iturmendi-Sabater I, Vasishth M, Barron D, Guardavaccaro M, Holmes A, McCarthy G, Eickhoff S, Sukhodolsky D. 89. Shared Disruptions in Neural Circuits of Eye Gaze Processing in Autism Spectrum Disorder and Schizophrenia. Biological Psychiatry 2024, 95: s135-s136. DOI: 10.1016/j.biopsych.2024.02.324.Peer-Reviewed Original ResearchReview: Evidence-Based Psychosocial Treatments for Childhood Irritability and Aggressive Behavior
Kalvin C, Zhong J, Rutten M, Ibrahim K, Sukhodolsky D. Review: Evidence-Based Psychosocial Treatments for Childhood Irritability and Aggressive Behavior. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.01.009.Peer-Reviewed Original ResearchCognitive-behavioral therapyParent management trainingDialectical behavior therapyChildhood irritabilityChildhood aggressionMaladaptive aggressionPsychosocial treatmentsPsychosocial interventionsReview of evidence-based psychosocial treatmentsDisruptive mood dysregulation disorderEvidence-based psychosocial treatmentsCo-occurring psychopathologySevere mood dysregulationOutpatient mental health servicesChild psychiatric disordersChild mental healthMental health servicesMood dysregulationBehavioral therapyDysregulation disorderPsychiatric disordersDisruptive behaviorWell-powered randomized controlled trialsAggressive behaviorRelevant to clinical practiceNeural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis
Ibrahim K, Iturmendi-Sabater I, Vasishth M, Barron D, Guardavaccaro M, Funaro M, Holmes A, McCarthy G, Eickhoff S, Sukhodolsky D. Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis. Schizophrenia Research 2024, 264: 298-313. PMID: 38215566, PMCID: PMC10922721, DOI: 10.1016/j.schres.2023.12.003.Peer-Reviewed Original ResearchConceptsRight inferior frontal gyrusAutism spectrum disorderInferior frontal gyrusEye gaze processingActivation likelihood estimationRight fusiform gyrusGaze processingFrontal gyrusFusiform gyrusFrontotemporal circuitryFunctional decodingSpectrum disorderActivation likelihood estimation meta-analysisMeta-analytic connectivity modelingMeta-analytic connectivityNeural circuit disruptionsTransdiagnostic biomarkerEmotional processingLeft amygdalaNeurobiological dysfunctionSocial cognitionEmotion perceptionNeural mechanismsSchizophreniaSpatial cognition
2023
Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety
Kalvin C, Jordan R, Rowley S, Weis A, Ibrahim K, Sukhodolsky D. Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety. Focus On Autism And Other Developmental Disabilities 2023, 38: 168-176. PMID: 38469453, PMCID: PMC10927274, DOI: 10.1177/10883576231165265.Peer-Reviewed Original ResearchAutism spectrum disorderSocial adaptive skillsAdaptive skillsSocial adaptiveAggressive behaviorSocial adaptive functioningSample of childrenAdaptive functioningASD diagnosisSpectrum disorderSocial functioningAge 8SkillsChildrenFunctioningAggressionAnxietyBehaviorParticipantsDisordersFindingsAdaptive
2022
Disruption in Large-Scale Brain Networks is Linked to Maladaptive Childhood Aggression
Ibrahim K, McCarthy G, Scheinost D, Sukhodolsky D. Disruption in Large-Scale Brain Networks is Linked to Maladaptive Childhood Aggression. Biological Psychiatry 2022, 91: s87. DOI: 10.1016/j.biopsych.2022.02.233.Peer-Reviewed Original ResearchAmygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment
Ibrahim K, Kalvin C, Morand-Beaulieu S, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment. Cerebral Cortex 2022, 32: 4371-4385. PMID: 35059702, PMCID: PMC9574236, DOI: 10.1093/cercor/bhab489.Peer-Reviewed Original ResearchConceptsSocial impairmentPrefrontal cortexEmotion processingMaladaptive aggressionAggressive behaviorSocial deficitsEmotion perception taskImplicit emotion processingFace emotion processingFunctional magnetic resonance imagingGreater social impairmentAmygdala-prefrontal connectivityChildhood-onset psychiatric disordersVentral prefrontal cortexDorsolateral prefrontal cortexFearful facesSocial cognitionPerception taskCalm facesSocial cuesTransdiagnostic sampleAmygdala reactivityParent ratingsPFC connectivityDiminished connectivity
2021
Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder
Morand-Beaulieu S, Smith SD, Ibrahim K, Wu J, Leckman JF, Crowley MJ, Sukhodolsky DG. Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder. Cortex 2021, 147: 157-168. PMID: 35042055, PMCID: PMC8816877, DOI: 10.1016/j.cortex.2021.12.006.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderGo/NoGo taskFrontal midline theta oscillationsFrontal midline theta powerEvent-related potentialsNoGo taskHyperactivity disorderInhibitory controlTheta powerTheta oscillationsP300 latencyInhibitory control abilitiesDense-array EEG recordingsDistinct electrophysiological profileTourette syndromeNeural underpinningsElectrophysiological correlatesTask performanceBehavioral performanceElectrophysiological signaturesP300 componentBrain activityN200Control abilityTaskIncreased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking childrenLarge-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DG. Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. Molecular Psychiatry 2021, 27: 985-999. PMID: 34690348, PMCID: PMC9035467, DOI: 10.1038/s41380-021-01317-5.Peer-Reviewed Original ResearchConceptsLarge-scale functional networksChildhood aggressionSeverity of aggressionIndividual differencesBrain networksAdolescent Brain Cognitive Development (ABCD) studyConnectome-based predictive modelingReactive-Proactive Aggression QuestionnaireEmotion perception taskLarge-scale functional brain networksAssociation of connectivityFunctional networksCognitive Development StudyAggressive behaviorFunctional brain networksIndependent samplesCognitive controlEmotion regulationEmotion processingPerception taskCalm facesMaladaptive aggressionPsychiatric disordersTransdiagnostic sampleFrontoparietal networkSocial cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder
Ibrahim K, Soorya LV, Halpern DB, Gorenstein M, Siper PM, Wang AT. Social cognitive skills groups increase medial prefrontal cortex activity in children with autism spectrum disorder. Autism Research 2021, 14: 2495-2511. PMID: 34486810, DOI: 10.1002/aur.2603.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMedial prefrontal cortexTheory of mindSocial skills groupsSchool-aged childrenSkill groupsSocial cognitionIrony comprehensionSkills interventionSpectrum disorderSocial functioningMedial prefrontal cortex activityComparison groupIrony Comprehension TaskSocial cognitive skillsEye gaze processingSocial skills interventionsFunctional MRI taskSocial Responsiveness ScalePrefrontal cortex activityFirst fMRI studyChildren ages 8Whole-brain analysisActive treatment conditionsGaze processingAnger Rumination in Children with Autism Spectrum Disorder
Ibrahim K, Jordan R, Rowley S, Sukhodolsky D. Anger Rumination in Children with Autism Spectrum Disorder. 2021, 205-209. DOI: 10.1007/978-3-319-91280-6_102452.Peer-Reviewed Original ResearchRDoC and Autism
Ibrahim K, Sukhodolsky D. RDoC and Autism. 2021, 3840-3841. DOI: 10.1007/978-3-319-91280-6_102261.Peer-Reviewed Original ResearchNeural Mechanisms of Emotional Dysregulation
Ibrahim K, McCarthy G, Sukhodolsky D. Neural Mechanisms of Emotional Dysregulation. 2021, 3115-3117. DOI: 10.1007/978-3-319-91280-6_102453.Peer-Reviewed Original ResearchConducting CBT for Anxiety in Children with Autism Spectrum Disorder During COVID-19 Pandemic
Kalvin CB, Jordan RP, Rowley SN, Weis A, Wood KS, Wood JJ, Ibrahim K, Sukhodolsky DG. Conducting CBT for Anxiety in Children with Autism Spectrum Disorder During COVID-19 Pandemic. Journal Of Autism And Developmental Disorders 2021, 51: 4239-4247. PMID: 33385281, PMCID: PMC7775616, DOI: 10.1007/s10803-020-04845-1.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyAutism spectrum disorderSpectrum disorderEngagement of childrenChild anxietyExposure exercisesTreatment fidelityCOVID-19 pandemicAnxietyTelehealth deliveryTreatment targetsChildrenRemote deliveryDisordersTreatment deliveryResearch protocolParentsQuarantine restrictionsEngagementPandemicNew reality
2020
Parent Emotion Socialization in Children with Autism Spectrum Disorder and Co-Occurring Anxiety
Jordan R, Kalvin CB, Ibrahim K, Sukhodolsky DG. Parent Emotion Socialization in Children with Autism Spectrum Disorder and Co-Occurring Anxiety. Research On Child And Adolescent Psychopathology 2020, 49: 125-137. PMID: 33442839, PMCID: PMC7809195, DOI: 10.1007/s10802-020-00731-7.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderChildren’s emotional experiencesParent emotion socializationEmotion socialization practicesNegative Emotions ScaleEmotional experienceEmotion socializationTD childrenSpectrum disorderSocialization practicesGreater anxietyParent emotion socialization practicesChildren's Negative Emotions ScaleSocialization approachEmotion-focused responsesASD symptom severityCo-occurring anxietyFamilies of childrenParents of childrenParent socializationEmotions ScalePsychiatric disordersChild anxietyFluent childrenLower anxietySex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior
Ibrahim K, Kalvin C, Li F, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior. Developmental Cognitive Neuroscience 2020, 47: 100884. PMID: 33254067, PMCID: PMC7704291, DOI: 10.1016/j.dcn.2020.100884.Peer-Reviewed Original ResearchConceptsDisruptive behavior disordersGray matter volumeCortical thicknessMatter volumeSex differencesDisruptive behavior severityCross-sectional studySex-specific associationsDisruptive behaviorLeft ventromedial prefrontal cortexWhole-brain analysisSurface-based morphometryStructural MRI dataHealthy controlsSex-specific differencesNeural biomarkersTarget-based treatmentVentromedial prefrontal cortexMedial prefrontalBehavior disorderPrefrontal cortexBrain structuresSupramarginal gyrusRespective controlsVmPFC volumeAssessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index
Kalvin CB, Gladstone TR, Jordan R, Rowley S, Marsh CL, Ibrahim K, Sukhodolsky DG. Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index. Journal Of Autism And Developmental Disorders 2020, 51: 1496-1507. PMID: 32734421, PMCID: PMC7855357, DOI: 10.1007/s10803-020-04627-9.Peer-Reviewed Original Research4516 Sex Differences in the Cortical Structure in Children with Irritability and Disruptive Behavior
Ibrahim K, Li F, He G, Pelphrey K, McCarthy G, Sukhodolsky D. 4516 Sex Differences in the Cortical Structure in Children with Irritability and Disruptive Behavior. Journal Of Clinical And Translational Science 2020, 4: 144-145. PMCID: PMC8823378, DOI: 10.1017/cts.2020.426.Peer-Reviewed Original ResearchFixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior
Grazioplene R, Tseng WL, Cimino K, Kalvin C, Ibrahim K, Pelphrey KA, Sukhodolsky DG. Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 5: 490-498. PMID: 32144044, PMCID: PMC7214205, DOI: 10.1016/j.bpsc.2019.12.018.Peer-Reviewed Original ResearchConceptsWhite matter densityCorpus callosumFiber densityAggressive behaviorCingulum bundleAbnormal interhemispheric connectivityHealthy control childrenWhite matter abnormalitiesAttention-deficit/hyperactivity disorderMiddle cerebellar peduncleSuperior thalamic radiationMagnetic resonance imagingInferior fronto-occipital fasciculusWhole-brain analysisInferior longitudinal fasciculusFronto-occipital fasciculusPotential neural mechanismsWhite matter microstructureDiffusion magnetic resonance imagingInterhemispheric connectivityCortical pathwaysCerebellar peduncleChild Behavior ChecklistThalamic radiationFiber bundle density