2022
Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment
Ibrahim K, Kalvin C, Morand-Beaulieu S, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment. Cerebral Cortex 2022, 32: 4371-4385. PMID: 35059702, PMCID: PMC9574236, DOI: 10.1093/cercor/bhab489.Peer-Reviewed Original ResearchConceptsSocial impairmentPrefrontal cortexEmotion processingMaladaptive aggressionAggressive behaviorSocial deficitsEmotion perception taskImplicit emotion processingFace emotion processingFunctional magnetic resonance imagingGreater social impairmentAmygdala-prefrontal connectivityChildhood-onset psychiatric disordersVentral prefrontal cortexDorsolateral prefrontal cortexFearful facesSocial cognitionPerception taskCalm facesSocial cuesTransdiagnostic sampleAmygdala reactivityParent ratingsPFC connectivityDiminished connectivity
2021
Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking childrenLarge-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DG. Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. Molecular Psychiatry 2021, 27: 985-999. PMID: 34690348, PMCID: PMC9035467, DOI: 10.1038/s41380-021-01317-5.Peer-Reviewed Original ResearchConceptsLarge-scale functional networksChildhood aggressionSeverity of aggressionIndividual differencesBrain networksAdolescent Brain Cognitive Development (ABCD) studyConnectome-based predictive modelingReactive-Proactive Aggression QuestionnaireEmotion perception taskLarge-scale functional brain networksAssociation of connectivityFunctional networksCognitive Development StudyAggressive behaviorFunctional brain networksIndependent samplesCognitive controlEmotion regulationEmotion processingPerception taskCalm facesMaladaptive aggressionPsychiatric disordersTransdiagnostic sampleFrontoparietal network
2020
Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index
Kalvin CB, Gladstone TR, Jordan R, Rowley S, Marsh CL, Ibrahim K, Sukhodolsky DG. Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index. Journal Of Autism And Developmental Disorders 2020, 51: 1496-1507. PMID: 32734421, PMCID: PMC7855357, DOI: 10.1007/s10803-020-04627-9.Peer-Reviewed Original Research
2019
Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder
Kalvin CB, Marsh CL, Ibrahim K, Gladstone TR, Woodward D, Grantz H, Ventola P, Sukhodolsky DG. Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder. Autism Research 2019, 13: 93-103. PMID: 31643143, PMCID: PMC7062240, DOI: 10.1002/aur.2220.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersAutism Spectrum DisorderChildFemaleHumansMaleParentsSelf ReportAnger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder
Ibrahim K, Kalvin C, Marsh CL, Anzano A, Gorynova L, Cimino K, Sukhodolsky DG. Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3656-3668. PMID: 31144231, PMCID: PMC7035789, DOI: 10.1007/s10803-019-04085-y.Peer-Reviewed Original ResearchReduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior
Ibrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 1031-1041. PMID: 30979647, PMCID: PMC7173634, DOI: 10.1016/j.bpsc.2019.01.009.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCallous-unemotional traitsAmygdala-vlPFC connectivityDisruptive behaviorAmygdala reactivityNeural mechanismsSpectrum disorderAmygdala-prefrontal functional connectivityEmotion perception taskFunctional magnetic resonance imagingVentrolateral prefrontal cortexUnderlying neural mechanismsDisruptive behavior disordersTask-specific changesRisk of aggressionEmotion dysregulationFearful facesCalm facesPerception taskFear processingAmygdala activityPsychophysiological interactionAmygdala connectivityExternalizing behaviorsAmygdala hyperactivity
2016
Meta-analysis of organizational skills interventions for children and adolescents with Attention-Deficit/Hyperactivity Disorder
Bikic A, Reichow B, McCauley SA, Ibrahim K, Sukhodolsky DG. Meta-analysis of organizational skills interventions for children and adolescents with Attention-Deficit/Hyperactivity Disorder. Clinical Psychology Review 2016, 52: 108-123. PMID: 28088557, DOI: 10.1016/j.cpr.2016.12.004.Peer-Reviewed Original ResearchNeural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward
Sukhodolsky DG, Wyk B, Eilbott JA, McCauley SA, Ibrahim K, Crowley MJ, Pelphrey KA. Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 38-48. PMID: 26784537, PMCID: PMC4779273, DOI: 10.1089/cap.2015.0164.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyReactive aggressionResearch Domain Criteria (RDoC) constructsSessions of CBTEmotional face perceptionEmotion regulation circuitryBrain-behavior associationsAggressive behaviorFunctional magnetic resonanceFace perceptionNon-RewardTraditional diagnostic categoriesNoGo taskFMRI scanningRDoC constructsElectrophysiological correlatesNeural mechanismsCriterion constructsFunctional neuroimagingBehavioral levelStrategic research prioritiesAge 8AggressionAdolescentsSupportive psychotherapyBehavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents
Sukhodolsky DG, Smith SD, McCauley SA, Ibrahim K, Piasecka JB. Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 58-64. PMID: 26745682, PMCID: PMC4808268, DOI: 10.1089/cap.2015.0120.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyParent management trainingAnger/irritabilityTransdiagnostic approachBehavioral interventionsDisruptive behaviorAggressive behaviorChild disruptive behaviorCallous-unemotional traitsDisruptive behavior disordersTreatment of irritabilityEmotion regulationAversive patternFamily interactionsBehavioral problemsAngerMental health referralsAggressionManagement trainingBehavior disorderMood disordersTreatment targetsIrritabilityChildrenPsychiatric diagnosis