Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking childrenLarge-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DG. Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. Molecular Psychiatry 2021, 27: 985-999. PMID: 34690348, PMCID: PMC9035467, DOI: 10.1038/s41380-021-01317-5.Peer-Reviewed Original ResearchConceptsLarge-scale functional networksChildhood aggressionSeverity of aggressionIndividual differencesBrain networksAdolescent Brain Cognitive Development (ABCD) studyConnectome-based predictive modelingReactive-Proactive Aggression QuestionnaireEmotion perception taskLarge-scale functional brain networksAssociation of connectivityFunctional networksCognitive Development StudyAggressive behaviorFunctional brain networksIndependent samplesCognitive controlEmotion regulationEmotion processingPerception taskCalm facesMaladaptive aggressionPsychiatric disordersTransdiagnostic sampleFrontoparietal network