Myocardial ER chaperone activation and protein degradation occurs due to synergistic, not individual, cold and hypoxic stress
Jain K, Suryakumar G, Prasad R, Singh SN, Ganju L. Myocardial ER chaperone activation and protein degradation occurs due to synergistic, not individual, cold and hypoxic stress. Biochimie 2013, 95: 1897-1908. PMID: 23816873, DOI: 10.1016/j.biochi.2013.06.018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCold TemperatureEndoplasmic Reticulum StressGene Expression RegulationHeat-Shock ProteinsHypoxiaHypoxia-Inducible Factor 1, alpha SubunitLipid PeroxidationMaleMyocardiumOxidation-ReductionProteasome Endopeptidase ComplexProtein CarbonylationProtein Disulfide-IsomerasesProtein FoldingProteolysisRatsRats, Sprague-DawleyTranscription Factor CHOPTunicamycinConceptsStress responseHypoxic stressCellular stress responseCell survival kinasesProtein oxidationEndoplasmic reticulum stress responseER stress responseER stress inducersReticulum stress responseMyocardial protein oxidationER chaperone GRP78Chaperone activationMisfolded proteinsEnvironmental stressProtein degradationChaperone GRP78Cold stressSurvival kinasesProtein oxidative modificationStress inducersHigh altitude stressMolecular levelCHOP expressionMatrix remodelingProteinUpregulation of Cytoprotective Defense Mechanisms and Hypoxia-Responsive Proteins Imparts Tolerance to Acute Hypobaric Hypoxia
Jain K, Suryakumar G, Prasad R, Ganju L. Upregulation of Cytoprotective Defense Mechanisms and Hypoxia-Responsive Proteins Imparts Tolerance to Acute Hypobaric Hypoxia. High Altitude Medicine & Biology 2013, 14: 65-77. PMID: 23537263, DOI: 10.1089/ham.2012.1064.Peer-Reviewed Original ResearchMeSH KeywordsAltitudeAnimalsAtmospheric PressureCatalaseCreatine Kinase, MB FormDyspneaEndothelin-1ErythropoietinHeme Oxygenase-1HSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMaleMalondialdehydeMyocarditisMyocardiumNitric OxideOxidative StressProtein CarbonylationRatsRats, Sprague-DawleyReactive Oxygen SpeciesSuperoxide DismutaseTime FactorsUp-RegulationVascular Endothelial Growth Factor AConceptsEnvironmental stressHypoxia-responsive proteinsSubsequent oxidative damageReactive oxygen species levelsCellular machineryHypoxia-responsive moleculesResponsive genesOxygen species levelsSpecies levelDifferential expressionTolerant animalsDefense mechanismsOxidative damageCytoprotective chaperoneAntioxidant enzymesHypobaric hypoxiaHigh expressionHIF-1αProteinAdult Sprague-Dawley ratsExpressionMyocardial antioxidant enzymesAcute hypobaric hypoxiaSprague-Dawley ratsCK-MB activity