2019
1454-P: Cerebral Glutathione Is Associated with Insulin Resistance in Older Individuals
PACH J, GROSKREUTZ D, LEVENTHAL J, KNIGHT M, JAIN K, HWA J, JIANG L, GRAAF R, HWANG J. 1454-P: Cerebral Glutathione Is Associated with Insulin Resistance in Older Individuals. Diabetes 2019, 68 DOI: 10.2337/db19-1454-p.Peer-Reviewed Original ResearchInsulin resistanceOlder individualsGSH levelsHOMA-IRReactive oxygen speciesOral glucose tolerance testPrefrontal cortexYoung individualsGlucose tolerance testPlasma reactive oxygen speciesPlasma GSH levelsCerebral GSH levelsCerebral glutathioneTolerance testMetabolic dysfunctionMetabolic diseasesNeurocognitive functionUseful markerCognitive deficitsMetabolic changesOxidative stressCr levelsNational InstituteStriatumVisual-spatial memory
2016
Enhanced hypoxic tolerance by Seabuckthorn is due to upregulation of HIF-1α and attenuation of ER stress
Jain K, Suryakumar G, Prasad R, Ganju L, Singh S. Enhanced hypoxic tolerance by Seabuckthorn is due to upregulation of HIF-1α and attenuation of ER stress. Journal Of Applied Biomedicine 2016, 14: 71-83. DOI: 10.1016/j.jab.2015.10.001.Peer-Reviewed Original ResearchHIF-1αHypoxic toleranceER stressAnti-inflammatory effectsPro-survival effectsFree radical productionCardioprotective actionCardiac damageHO-1NF-κBHerbal supplementsKey adaptive responseOxidative stressTwo-fold increaseHsp70 levelsAntioxidant potentialProtein carbonylationRadical productionHypoxiaSignificant declineSignaling cascadesAdaptive responseCross talkNovel insightsRedox homeostasis