Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
Alavian KN, Sgadò P, Alberi L, Subramaniam S, Simon HH. Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Development 2009, 4: 11. PMID: 19291307, PMCID: PMC2667502, DOI: 10.1186/1749-8104-4-11.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DeathCells, CulturedDisease Models, AnimalDopamineHeterozygoteHomeodomain ProteinsImmunohistochemistryMesencephalonMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MutationNerve Tissue ProteinsNeuronsParkinson DiseaseReceptors, Nerve Growth FactorReverse Transcriptase Polymerase Chain ReactionUp-RegulationConceptsMesDA neuronsBcl-2 familyAnti-apoptotic membersCell death signalsExpression levelsMutant embryosHaplotype variationDeath signalsMitochondrial stabilityEngrailedERK1/2 activityEngrailed-1Mitochondrial insultDopaminergic neuronsGenesPostnatal maintenanceReceptor geneElevated expressionMidbrain dopaminergic neuronsHeterozygote animalsDependent mannerMutant miceNigrostriatal dopaminergic systemERK1/2 suppressionMesencephalic dopaminergic neurons