2009
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression
Alavian KN, Sgadò P, Alberi L, Subramaniam S, Simon HH. Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Development 2009, 4: 11. PMID: 19291307, PMCID: PMC2667502, DOI: 10.1186/1749-8104-4-11.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DeathCells, CulturedDisease Models, AnimalDopamineHeterozygoteHomeodomain ProteinsImmunohistochemistryMesencephalonMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MutationNerve Tissue ProteinsNeuronsParkinson DiseaseReceptors, Nerve Growth FactorReverse Transcriptase Polymerase Chain ReactionUp-RegulationConceptsMesDA neuronsBcl-2 familyAnti-apoptotic membersCell death signalsExpression levelsMutant embryosHaplotype variationDeath signalsMitochondrial stabilityEngrailedERK1/2 activityEngrailed-1Mitochondrial insultDopaminergic neuronsGenesPostnatal maintenanceReceptor geneElevated expressionMidbrain dopaminergic neuronsHeterozygote animalsDependent mannerMutant miceNigrostriatal dopaminergic systemERK1/2 suppressionMesencephalic dopaminergic neurons
2007
Transcriptional regulation of mesencephalic dopaminergic neurons: The full circle of life and death
Alavian KN, Scholz C, Simon HH. Transcriptional regulation of mesencephalic dopaminergic neurons: The full circle of life and death. Movement Disorders 2007, 23: 319-328. PMID: 18044702, DOI: 10.1002/mds.21640.BooksConceptsTranscription factorsMesencephalic dopaminergic neuronsDopaminergic neuronsLmx1a/bTranscriptional regulationMolecular mechanismsEssential processCellular propertiesSynapse formationDisease mechanismsNeurotransmitter phenotypeLong-term survivalIntense investigationTarget innervationVentral midbrainParkinson's diseaseNeuronal populationsNeurodegenerative ailmentsNeuronsGenesDiseasePitx3PhenotypeNurr1Regulation
2006
Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
Sgadò P, Albéri L, Gherbassi D, Galasso SL, Ramakers GM, Alavian KN, Smidt MP, Dyck RH, Simon HH. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 15242-15247. PMID: 17015829, PMCID: PMC1622807, DOI: 10.1073/pnas.0602116103.Peer-Reviewed Original ResearchConceptsDopaminergic neuronsProgressive degenerationParkinson's diseaseMutant miceEngrailed-1Postnatal mutant miceSlow progressive degenerationNigral dopaminergic neuronsMesencephalic dopaminergic neuronsRelease of dopamineKey pathological featureLower body weightMotor deficitsPathological featuresSubstantia nigraCaudate putamenNovel treatmentsBody weightNeurodegenerative disordersHeterozygous nullDiseaseMiceNeuronsMolecular etiologyDependent manner