2016
Unexpected functional implication of a stable succinimide in the structural stability of Methanocaldococcus jannaschii glutaminase
Kumar S, Prakash S, Gupta K, Dongre A, Balaram P, Balaram H. Unexpected functional implication of a stable succinimide in the structural stability of Methanocaldococcus jannaschii glutaminase. Nature Communications 2016, 7: 12798. PMID: 27677693, PMCID: PMC5052720, DOI: 10.1038/ncomms12798.Peer-Reviewed Original Research
2011
Ammonia Channeling in Plasmodium falciparum GMP Synthetase: Investigation by NMR Spectroscopy and Biochemical Assays
Bhat JY, Venkatachala R, Singh K, Gupta K, Sarma SP, Balaram H. Ammonia Channeling in Plasmodium falciparum GMP Synthetase: Investigation by NMR Spectroscopy and Biochemical Assays. Biochemistry 2011, 50: 3346-3356. PMID: 21413787, DOI: 10.1021/bi1017057.Peer-Reviewed Original ResearchConceptsGMP synthetasePlasmodium falciparum GMP synthetaseBiochemical assaysPurine biosynthetic pathwayAmmonia channelingGlutamine amidotransferasesGlutaminase domainMolecular tunnelBiosynthetic pathwayCatalytic residuesGlutaminase siteSeparate active sitesExternal mediumThioester intermediateExternal ammoniaCys-102NMR spectroscopyConcentration of glutamineSynthetaseUncompetitive inhibitorGlutamineActive siteSynthetase siteProton NMR spectroscopyAssays