2024
Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries
Ma Y, Nobile F, Marb A, Dubrow R, Stafoggia M, Breitner S, Kinney P, Chen K. Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries. JAMA Network Open 2024, 7: e2354607. PMID: 38427355, PMCID: PMC10907920, DOI: 10.1001/jamanetworkopen.2023.54607.Peer-Reviewed Original ResearchConceptsShort-term exposure to air pollutionExposure to air pollutionFine particulate matterCross-sectional studyAir pollutionFixed-effects modelParticulate matterShort-term exposure to PM2.5Short-term exposure to fine particulate matterNO2 concentrationsExposure to fine particulate matterMortality rateNitrogen dioxideSignificant effect modificationDaily PM2.5 concentrationsTime-varying confoundersExposure to PM2.5Health outcomesEstimate associationsMortality dataEffect modificationPM2.5 concentrationsMain OutcomesDay-to-dayCentral-southern ItalyA unified framework for assessing interaction effects among environmental exposures in epidemiologic studies: A case study on temperature, air pollution, and kidney-related conditions in New York state
Chu L, Chen K, Yang Z, Crowley S, Dubrow R. A unified framework for assessing interaction effects among environmental exposures in epidemiologic studies: A case study on temperature, air pollution, and kidney-related conditions in New York state. Environmental Research 2024, 248: 118324. PMID: 38301759, DOI: 10.1016/j.envres.2024.118324.Peer-Reviewed Original ResearchAir pollutionMultiplicative interaction effectsNew York StateEstimated health burdenCase-crossover designEvaluation of effect modificationBi-variate associationsAssess interaction effectsConditional logistic modelMeasures of exposureInteraction effectsEffect modificationPollutionExposure variablesHealth burdenEpidemiological studiesEnvironmental exposuresLog-linear modelLogistic modelInteraction termsQuantitative frameworkAirCase studyExposureAlert systemEffects of air pollution on emergency room visits for mental disorders: risks and effect modification by comorbid physical disorders and personal characteristics
Yoo E, Roberts J, Chen K. Effects of air pollution on emergency room visits for mental disorders: risks and effect modification by comorbid physical disorders and personal characteristics. Environmental Research Health 2024, 2: 025001. DOI: 10.1088/2752-5309/ad1f3f.Peer-Reviewed Original ResearchComorbid physical disordersMental disordersPhysical disordersPersonal characteristicsEffect modificationER visitsNegatively impact mental healthAssociated with ER visitsPotential effect modificationCase-crossover designPotential moderatorsEffects of air pollutionEmergency room visitsEmergency roomMental healthRespiratory diseaseDisordersLevels of air pollutionStratified analysisRoom visitsEffects of daily changesAir pollutionDemographic characteristicsVisitsPrimary diagnosis
2023
Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries
Wang P, Asare E, Pitzer V, Dubrow R, Chen K. Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries. JAMA Pediatrics 2023, 177: 1206-1214. PMID: 37782513, PMCID: PMC10546297, DOI: 10.1001/jamapediatrics.2023.3964.Peer-Reviewed Original ResearchConceptsMiddle-income countriesDiarrhea riskOdds ratioMAIN OUTCOMEMixed-effects logistic regression modelRisk of diarrheaCross-sectional studyHigher odds ratioPrevalence of diarrheaLogistic regression modelsHealth survey programUnexposed childrenEffect modificationChild healthDiarrhea prevalenceSurvey clustersSignificant associationHygiene practicesFourth weekWeeksStrong associationRandom interceptYoung childrenChildrenDiarrhea
2022
Triggering of myocardial infarction by heat exposure is modified by medication intake
Chen K, Dubrow R, Breitner S, Wolf K, Linseisen J, Schmitz T, Heier M, von Scheidt W, Kuch B, Meisinger C, Peters A, Schneider A. Triggering of myocardial infarction by heat exposure is modified by medication intake. Nature Cardiovascular Research 2022, 1: 727-731. PMID: 39196082, DOI: 10.1038/s44161-022-00102-z.Peer-Reviewed Original ResearchMyocardial infarctionEffect modificationMI riskPre-existing coronary heart diseaseAnti-platelet medicationCertain cardiovascular medicationsBeta-receptor blockersCoronary heart diseaseAcute myocardial infarctionHeat exposureCardiovascular medicationsOlder patientsYounger patientsMedication useMedication intakeHeart diseaseHigh prevalenceLow prevalenceMI casesMedicationsPatientsInfarctionSignificant differencesCHDPrevalence
2021
Association between extreme temperatures and emergency room visits related to mental disorders: A multi-region time-series study in New York, USA
Yoo EH, Eum Y, Roberts JE, Gao Q, Chen K. Association between extreme temperatures and emergency room visits related to mental disorders: A multi-region time-series study in New York, USA. The Science Of The Total Environment 2021, 792: 148246. PMID: 34144243, DOI: 10.1016/j.scitotenv.2021.148246.Peer-Reviewed Original ResearchConceptsEmergency room visitsER visitsMental disordersRoom visitsShort-term exposurePotential effect modificationMental health disordersSpecific mental disordersPositive associationRace/ethnicityEffect modificationExposure-response curvesStratified analysisLag non-linear modelHealth disordersTime-series studySubstance abuseRisk estimatesAnxiety disordersVisitsDisordersMental diseasesCertain populationsSignificant differencesTime trends
2018
Two-way effect modifications of air pollution and air temperature on total natural and cardiovascular mortality in eight European urban areas
Chen K, Wolf K, Breitner S, Gasparrini A, Stafoggia M, Samoli E, Andersen ZJ, Bero-Bedada G, Bellander T, Hennig F, Jacquemin B, Pekkanen J, Hampel R, Cyrys J, Peters A, Schneider A, Group U. Two-way effect modifications of air pollution and air temperature on total natural and cardiovascular mortality in eight European urban areas. Environment International 2018, 116: 186-196. PMID: 29689465, DOI: 10.1016/j.envint.2018.04.021.Peer-Reviewed Original ResearchConceptsCardiovascular mortalityAmbient air pollutionShort-term associationsTemperature-mortality associationCity-specific effect estimatesEffect modificationHigh air pollutionMortality riskEpidemiological studiesInfluenza epidemicsMortalityEffect estimatesMortality effectsAir pollutionDaily mortalityAssociationDaysAir pollution levelsDistributed lag
2014
Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China
Chen K, Bi J, Chen J, Chen X, Huang L, Zhou L. Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China. The Science Of The Total Environment 2014, 506: 18-25. PMID: 25460935, DOI: 10.1016/j.scitotenv.2014.10.092.Peer-Reviewed Original ResearchConceptsDifferent heat wave definitionsDisease mortalityChronic obstructive pulmonary disease (COPD) mortalityIschemic heart disease mortalityLag day 2Heart disease mortalityBurden of diseaseCause-specific mortalityDaily mortalityCardiovascular mortalityStroke mortalityEffect modificationHeat wave definitionsStratified analysisRespiratory mortalityDay 2Total mortalityMortalityConsecutive daysHeat warning systemsLower educationDaysAssociationGood model fitCritical role