2012
Plasma osteopontin velocity differentiates lung cancers from controls in a CT screening population
Joseph S, Harrington R, Walter D, Goldberg JD, Li X, Beck A, Litton T, Hirsch N, Blasberg J, Slomiany M, Rom W, Pass H, Donington J. Plasma osteopontin velocity differentiates lung cancers from controls in a CT screening population. Cancer Biomarkers 2012, 12: 177-184. PMID: 23568008, PMCID: PMC3746829, DOI: 10.3233/cbm-130306.Peer-Reviewed Original ResearchConceptsIncident cancerPlasma osteopontinNon-small cell lung cancer careLung cancer careCase-control studySerial plasmaNSCLC patientsCT screeningSurveillance intervalsCancer careLung cancerPlasma levelsWilcoxon Signed Rank TestDisease statusCancerSigned Rank TestBenign nodulesSecreted phosphoproteinCTRank testOsteopontinEarly evidenceNSCLCPatientsNSCLCs
2010
Functional Heterogeneity of Osteopontin Isoforms in Non-small Cell Lung Cancer
Goparaju CM, Pass HI, Blasberg JD, Hirsch N, Donington JS. Functional Heterogeneity of Osteopontin Isoforms in Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2010, 5: 1516-1523. PMID: 20689445, PMCID: PMC3122268, DOI: 10.1097/jto.0b013e3181eba6bd.Peer-Reviewed Original ResearchApoptosisBiomarkers, TumorBlotting, WesternCarcinoma, Non-Small-Cell LungCell AdhesionCell Line, TumorCell MovementCell ProliferationColony-Forming Units AssayEpithelial-Mesenchymal TransitionGene Expression ProfilingHumansLung NeoplasmsOligonucleotide Array Sequence AnalysisOsteopontinProtein IsoformsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerWound HealingReduction of Elevated Plasma Osteopontin Levels With Resection of Non–Small-Cell Lung Cancer
Blasberg JD, Pass HI, Goparaju CM, Flores RM, Lee S, Donington JS. Reduction of Elevated Plasma Osteopontin Levels With Resection of Non–Small-Cell Lung Cancer. Journal Of Clinical Oncology 2010, 28: 936-941. PMID: 20085934, PMCID: PMC2834433, DOI: 10.1200/jco.2009.25.5711.Peer-Reviewed Original ResearchConceptsEarly-stage NSCLCPlasma osteopontin levelsPlasma OPN levelsOPN levelsEnzyme-linked immunosorbent assayPlasma OPNOsteopontin levelsWeeks postsurgeryElevated Plasma Osteopontin LevelsCell lung cancer correlatesUse of thoracotomyCell lung cancerLung cancer correlatesCancer-free smokersResectable NSCLCPerioperative eventsTumor characteristicsPresurgery levelsRecurrence rateValidation cohortLung cancerCancer correlatesTherapeutic responseNSCLCIndependent cohort
2009
Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity
Blasberg JD, Goparaju CM, Pass HI, Donington JS. Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. Journal Of Thoracic And Cardiovascular Surgery 2009, 139: 1587-1593. PMID: 19818970, PMCID: PMC2875279, DOI: 10.1016/j.jtcvs.2009.08.016.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factor (VEGF) secretionGrowth factor secretionCell lung cancerLung cancer angiogenesisEnzyme-linked immunosorbentOsteopontin isoformsFactor secretionLung cancerNon-small cell lung cancer (NSCLC) pathogenesisCancer angiogenesisCell linesNon-small cell lung cancerVascular endothelial growth factor levelsMRNA expressionCell lung cancer cell linesLung cancer pathogenesisGrowth factor levelsLung cancer cell linesVascular endothelial growth factorTubule lengthImmortalized bronchial epithelial cell lineEndothelial growth factorBronchial epithelial cell lineOsteopontin secretionCancer cell lines