2010
Functional Heterogeneity of Osteopontin Isoforms in Non-small Cell Lung Cancer
Goparaju CM, Pass HI, Blasberg JD, Hirsch N, Donington JS. Functional Heterogeneity of Osteopontin Isoforms in Non-small Cell Lung Cancer. Journal Of Thoracic Oncology 2010, 5: 1516-1523. PMID: 20689445, PMCID: PMC3122268, DOI: 10.1097/jto.0b013e3181eba6bd.Peer-Reviewed Original ResearchApoptosisBiomarkers, TumorBlotting, WesternCarcinoma, Non-Small-Cell LungCell AdhesionCell Line, TumorCell MovementCell ProliferationColony-Forming Units AssayEpithelial-Mesenchymal TransitionGene Expression ProfilingHumansLung NeoplasmsOligonucleotide Array Sequence AnalysisOsteopontinProtein IsoformsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerWound Healing
2009
Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity
Blasberg JD, Goparaju CM, Pass HI, Donington JS. Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. Journal Of Thoracic And Cardiovascular Surgery 2009, 139: 1587-1593. PMID: 19818970, PMCID: PMC2875279, DOI: 10.1016/j.jtcvs.2009.08.016.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factor (VEGF) secretionGrowth factor secretionCell lung cancerLung cancer angiogenesisEnzyme-linked immunosorbentOsteopontin isoformsFactor secretionLung cancerNon-small cell lung cancer (NSCLC) pathogenesisCancer angiogenesisCell linesNon-small cell lung cancerVascular endothelial growth factor levelsMRNA expressionCell lung cancer cell linesLung cancer pathogenesisGrowth factor levelsLung cancer cell linesVascular endothelial growth factorTubule lengthImmortalized bronchial epithelial cell lineEndothelial growth factorBronchial epithelial cell lineOsteopontin secretionCancer cell lines