2019
Quantitative FDG PET/CT may help risk-stratify early-stage non-small cell lung cancer patients at risk for recurrence following anatomic resection
Harmon S, Seder CW, Chen S, Traynor A, Jeraj R, Blasberg JD. Quantitative FDG PET/CT may help risk-stratify early-stage non-small cell lung cancer patients at risk for recurrence following anatomic resection. Journal Of Thoracic Disease 2019, 11: 1106-1116. PMID: 31179052, PMCID: PMC6531752, DOI: 10.21037/jtd.2019.04.46.Peer-Reviewed Original ResearchDisease-free survivalSquamous cell carcinomaNon-small cell lung cancer patientsStandardized uptake valueCell lung cancer patientsEarly-stage NSCLCLung cancer patientsDisease recurrenceAnatomic resectionOverall survivalCancer patientsF-fluorodeoxyglucose positron emission tomography/computerized tomographyEarly stage non-small cell lung cancer patientsStage I/II NSCLC patientsPositron emission tomography/computerized tomographyCox proportional hazards regressionFDG PET/CTTomography/computerized tomographyQuantitative FDG-PET/CTPathologic node statusYears of resectionPreoperative risk factorsHigh-risk patientsSignificant univariate predictorsPrimary tumor volume
2018
Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose
Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose. Physics In Medicine And Biology 2018, 63: 175015. PMID: 30095083, PMCID: PMC6158045, DOI: 10.1088/1361-6560/aad97f.Peer-Reviewed Original ResearchConceptsPopulation-based input functionStandardized uptake valueImage-derived input functionLung nodulesClinical trialsTime-activity curvesLow-dose computed tomography (LDCT) screeningLung cancer mortality ratesIndeterminate lung nodulesComputed Tomography ScreeningF-FDG PETCancer mortality ratesStatic PET acquisitionVirtual clinical trialsScan durationTomography screeningFDG injectionPET scansMortality rateUptake valueAccurate diagnosisMalignant lung nodulesROC analysisPatient dataMalignant nodules