2011
Onconase mediated NFKβ downregulation in malignant pleural mesothelioma
Goparaju CM, Blasberg JD, Volinia S, Palatini J, Ivanov S, Donington JS, Croce C, Carbone M, Yang H, Pass HI. Onconase mediated NFKβ downregulation in malignant pleural mesothelioma. Oncogene 2011, 30: 2767-2777. PMID: 21317924, PMCID: PMC3118086, DOI: 10.1038/onc.2010.643.Peer-Reviewed Original ResearchConceptsDownstream targetsMiRNA mimicsCell linesCell proliferationSoft agar colony formationMPM cell linesMiRNA expression patternsAgar colony formationProtein translationABC transportersExpression patternsGene expressionReverse transcription-PCRSpecific microRNAsBcl-xLCertain miRNAsMiRNA expressionOnconaseFunctional assaysClosure assayFunctional implicationsMatrigel invasionColony formationCell apoptosisNuclear factor kappa B
2009
Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity
Blasberg JD, Goparaju CM, Pass HI, Donington JS. Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. Journal Of Thoracic And Cardiovascular Surgery 2009, 139: 1587-1593. PMID: 19818970, PMCID: PMC2875279, DOI: 10.1016/j.jtcvs.2009.08.016.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factor (VEGF) secretionGrowth factor secretionCell lung cancerLung cancer angiogenesisEnzyme-linked immunosorbentOsteopontin isoformsFactor secretionLung cancerNon-small cell lung cancer (NSCLC) pathogenesisCancer angiogenesisCell linesNon-small cell lung cancerVascular endothelial growth factor levelsMRNA expressionCell lung cancer cell linesLung cancer pathogenesisGrowth factor levelsLung cancer cell linesVascular endothelial growth factorTubule lengthImmortalized bronchial epithelial cell lineEndothelial growth factorBronchial epithelial cell lineOsteopontin secretionCancer cell lines