Human multipotent stromal cells from bone marrow and microRNA: Regulation of differentiation and leukemia inhibitory factor expression
Oskowitz AZ, Lu J, Penfornis P, Ylostalo J, McBride J, Flemington EK, Prockop DJ, Pochampally R. Human multipotent stromal cells from bone marrow and microRNA: Regulation of differentiation and leukemia inhibitory factor expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 18372-18377. PMID: 19011087, PMCID: PMC2587615, DOI: 10.1073/pnas.0809807105.Peer-Reviewed Original ResearchConceptsHuman multipotent stromal cellsMultipotent stromal cellsAdipogenic differentiationRegulation of differentiationExpression of DicerStromal cellsExpression analysisHMSC differentiationEarly transcriptsFactor expressionMiRNAsLeukemia inhibitory factor expressionOsteogenic differentiationDifferentiationBone marrowExpressionDicerDroshaCellsSilico modelsMicroRNAsMiRNATranscriptsShRNAsEnzymeDistinct microRNA expression profiles in acute myeloid leukemia with common translocations
Li Z, Lu J, Sun M, Mi S, Zhang H, Luo RT, Chen P, Wang Y, Yan M, Qian Z, Neilly MB, Jin J, Zhang Y, Bohlander SK, Zhang DE, Larson RA, Le Beau MM, Thirman MJ, Golub TR, Rowley JD, Chen J. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15535-15540. PMID: 18832181, PMCID: PMC2563085, DOI: 10.1073/pnas.0808266105.Peer-Reviewed Original ResearchConceptsPolo-like kinase 2Genome-wide miRNA expression analysisDistinct miRNA expression patternsMiRs-126/126Normal bone marrow progenitor cellsMiRNA expression patternsCommon translocationBone marrow progenitor cellsGenomic lociMiRNA expression analysisExpression analysisMarrow progenitor cellsAcute myeloid leukemia samplesExpression patternsSpecific miRNAsKinase 2Expression profilesTumor suppressorFunction experimentsGenetic rearrangementsPromoter demethylationColony-forming abilityImportant regulatorAML1-ETOExpression signatures