2017
A measurement-based generalized source model for Monte Carlo dose simulations of CT scans
Ming X, Feng Y, Liu R, Yang C, Zhou L, Zhai H, Deng J. A measurement-based generalized source model for Monte Carlo dose simulations of CT scans. Physics In Medicine And Biology 2017, 62: 1759-1776. PMID: 28079526, PMCID: PMC5857954, DOI: 10.1088/1361-6560/aa5911.Peer-Reviewed Original ResearchConceptsMonte Carlo dose simulationsGeneralized source modelEnergy spectrumFluence distributionDose profilesCentral axis percent depth dose curvePercent depth dose curvesDose simulationsDepth dose curvesMonte Carlo user codeSource distributionBeam inputDose curvesFilm measurementsCTDI phantomCT scannerOutput factorsAbsolute dose comparisonsMonte Carlo simulationsDose distributionSource modelCarlo simulationsCircular sourceGE LightspeedScanner specifications
2016
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study
Zhang Y, Feng Y, Ming X, Deng J. Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study. BioMed Research International 2016, 2016: 7319843. PMID: 26977413, PMCID: PMC4763028, DOI: 10.1155/2016/7319843.Peer-Reviewed Original ResearchConceptsIMRT plansPediatric brain tumorsNovel treatment modalitiesNormal tissue sparingDifferent tumor sitesDosimetric gainLung cancerTreatment modalitiesIndividual patientsBrain tumorsTissue sparingIMRT techniqueTumor sitePersonalized carePhoton radiotherapyThyroid lesionsDose distributionIntegral doseRadiotherapy treatmentInverse planning systemPatientsRadiotherapyFeasibility studyModern radiotherapy treatmentsClinical IMRT plans
2013
SU‐E‐T‐462: Energy Modulated Photon Radiotherapy: A Monte Carlo Investigation
Zhang Y, Feng Y, Ming X, Nath R, Deng J. SU‐E‐T‐462: Energy Modulated Photon Radiotherapy: A Monte Carlo Investigation. Medical Physics 2013, 40: 311-311. DOI: 10.1118/1.4814895.Peer-Reviewed Original ResearchIMRT plansProstate cancer patientsPhoton radiation therapyBeam energyPhoton beamsCancer patientsNeck cancerPrescription doseEclipse treatment planning systemDose reductionRadiation therapyBEAM Monte Carlo codePencil beam dose distributionsDVH analysisTumor sitePhoton radiotherapyDose distributionNormal tissuesPatientsLow-energy photonsPhoton beam intensityBeam dose distributionsTarget coverageOptimal beam energyIntegral dose
2012
4D Dynamic Simulation of Patients Undergoing Radiotherapy
Deng J, Nath R. 4D Dynamic Simulation of Patients Undergoing Radiotherapy. 2012, 1: 1-4. DOI: 10.1109/vecims.2012.6273228.Peer-Reviewed Original ResearchMonte Carlo radiation transport simulationsX-ray imagerRadiation transport simulationsExternal ionizing radiationMultiple source modelImage-guided radiotherapyLinear acceleratorDigital phantomAdvanced medical imaging technologiesIonizing RadiationTransport simulationsDose registrationDose distributionOrgan dosesRadiationPhantomMedical imaging technologyImaging technologyDynamics simulationsMedical imaging proceduresAdaptive radiotherapyAcceleratorImagerCT informationSource model
2009
Monte Carlo Investigation of Stereotactic Radiosurgery of Spinal Metastases
Deng J, Chen Z, Knisely J, Decker R, Chiang V, Nath R. Monte Carlo Investigation of Stereotactic Radiosurgery of Spinal Metastases. IFMBE Proceedings 2009, 25/1: 13-16. DOI: 10.1007/978-3-642-03474-9_4.Peer-Reviewed Original ResearchSpinal metastasesStereotactic radiosurgeryDose-volume histogramsMean doseAnalytical anisotropic algorithmRisk of recurrenceTarget dose coverageDose distributionPencil beam convolutionSpinal cordDose coverageTarget dosePTV doseTreatment planMetastasisHomogeneity indexDoseRadiosurgeryPBC resultsPatientsTreatment planning systemPatient anatomyCommercial treatment planning systemDose discrepanciesAccurate dose distribution
2008
SU‐GG‐T‐493: Dosimetric Impact of Beam Energy and Number of Photon Fields On Prostate Dose Distributions: Inverse Planning and Validation Study
Ahmad M, Lund M, Halpin H, Deng J, Chen Z, Mani S, Moran M, Nath R. SU‐GG‐T‐493: Dosimetric Impact of Beam Energy and Number of Photon Fields On Prostate Dose Distributions: Inverse Planning and Validation Study. Medical Physics 2008, 35: 2838-2838. DOI: 10.1118/1.2962242.Peer-Reviewed Original ResearchPlanning target volumeComputerized tomographyTreatment planIMRT techniqueTarget volumeNormal tissuesIrradiated normal tissueDose distributionSuperior dose distributionProstate target volumeInverse planningProstate cancerProstate carcinomaLesser dosesSample patientsBeam arrangementsDose constraintsDosimetric differencesPatientsDose uniformityProstate patientsIMRT plansDosimetric impactIntegral doseInverse planning process
2006
SU‐FF‐T‐361: Planning Study of Intensity‐Modulated and 3D Conformal Radiotherapy of Whole Pelvis Including Inguinal Lymphatics: Radiobiological Considerations for Designing New Fractionation Schemes
Ahmad M, Song H, Lund M, Niemierko A, Moran M, Weidhaas J, Higgins S, Chen Z, Deng J, Nath R. SU‐FF‐T‐361: Planning Study of Intensity‐Modulated and 3D Conformal Radiotherapy of Whole Pelvis Including Inguinal Lymphatics: Radiobiological Considerations for Designing New Fractionation Schemes. Medical Physics 2006, 33: 2129-2129. DOI: 10.1118/1.2241281.Peer-Reviewed Original ResearchNormal tissue complication probabilityNode irradiationTumor control probabilityEquivalent uniform doseSIB-IMRTBoost plansTarget volumeNormal tissuesSimultaneous integrated boostShorter treatment durationIntensity-modulated radiotherapyPotential clinical advantagesAnal cancerSuperior dose distributionDose distributionDose escalationPrimary diseasePelvic malignanciesAdvanced tumorsWhole pelvisPrimary tumorSubclinical diseaseImproved outcomesIntegrated boostConformal radiotherapyEvaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams
Ahmad M, Chen Z, Song H, Deng J, Nath R. Evaluation of the EDR-2 film for relative dosimetry of high-energy photon and electron beams. Radiation Protection Dosimetry 2006, 120: 159-162. PMID: 16644932, DOI: 10.1093/rpd/ncj006.Peer-Reviewed Original ResearchConceptsEDR-2 filmsElectron beamRelative dosimetryHigh-energy photonsClinical radiation dosimetryDose profilesPhotonsRadiation dosimetryBeamDose distributionRadiographic filmsSensitometric studyFilmsDosimetryTreatment planning techniquesElectronsDiodesSymmetryKVFlatnessPlanning techniquesDistribution
2004
Imrt of whole pelvis and inguinal nodes: Evaluation of dose distributions produced by an inverse treatment planning system
Ahmad M, Song H, Moran M, Lund M, Chen Z, Deng J, Haffty B, Nath R. Imrt of whole pelvis and inguinal nodes: Evaluation of dose distributions produced by an inverse treatment planning system. International Journal Of Radiation Oncology • Biology • Physics 2004, 60: s484-s485. DOI: 10.1016/j.ijrobp.2004.07.410.Peer-Reviewed Original Research
2003
Dose correlation for thoracic motion in radiation therapy of breast cancer
Ding M, Li J, Deng J, Fourkal E, Ma C. Dose correlation for thoracic motion in radiation therapy of breast cancer. Medical Physics 2003, 30: 2520-2529. PMID: 14528974, DOI: 10.1118/1.1603744.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsBreast NeoplasmsHumansMammographyMotionMovementOnline SystemsPhantoms, ImagingRadiographic Image Interpretation, Computer-AssistedRadiography, ThoracicRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsRespirationSensitivity and SpecificityStatistics as TopicThoraxTomography, X-Ray ComputedConceptsBreathing patternDose correlationBreast cancerChest wall motionChest wall movementPatient's breathing patternDose dataRadiation therapyThoracic motionRadiotherapy treatmentTreatment planningExpiration phaseDifferent breathing phasesFinal dose distributionCancerBreathing phasesPatient anatomyWall motionTreatmentDose distributionCT dataBreathing levelTherapyDosePatient geometry
2002
A Monte Carlo investigation of fluence profiles collimated by an electron specific MLC during beam delivery for modulated electron radiation therapy
Deng J, Lee MC, Ma C. A Monte Carlo investigation of fluence profiles collimated by an electron specific MLC during beam delivery for modulated electron radiation therapy. Medical Physics 2002, 29: 2472-2483. PMID: 12462711, DOI: 10.1118/1.1513160.Peer-Reviewed Original ResearchConceptsFluence profilesVarian Clinac 2100C linear acceleratorElectron radiation therapyElectron beamMonte Carlo methodBeam energyBeam deliveryMonte Carlo investigationElectron beam energyCarlo methodMonte CarloOff-axis locationBEAM codeSigmoid functionLeaf endsEnergy dependenceInverse planning algorithmLinear acceleratorVariable energyMLC aperturesOperatorsBeamField sizeDose distributionMultileaf collimator
2001
Monte Carlo based treatment planning for modulated electron beam radiation therapy
Lee M, Deng J, Li J, Jiang S, Ma C. Monte Carlo based treatment planning for modulated electron beam radiation therapy. Physics In Medicine And Biology 2001, 46: 2177-2199. PMID: 11512618, DOI: 10.1088/0031-9155/46/8/310.Peer-Reviewed Original ResearchConceptsElectron multileaf collimatorIntensity mapsDose distributionElectron radiation therapyElectron beamletsElectron energyElectron beam radiation therapyAir scatteringMonte CarloBremsstrahlung contributionConformal dose distributionsMonte Carlo simulationsBeamletsScatter dosesTreatment planning systemElectronsMultileaf collimatorCarlo simulationsBreast plansIrregular targetsLeaf transportCarloScatteringMonte Carlo generationCollimatorThe MLC tongue-and-groove effect on IMRT dose distributions
Deng J, Pawlicki T, Chen Y, Li J, Jiang S, Ma C. The MLC tongue-and-groove effect on IMRT dose distributions. Physics In Medicine And Biology 2001, 46: 1039-1060. PMID: 11324950, DOI: 10.1088/0031-9155/46/4/310.Peer-Reviewed Original Research
2000
Monte Carlo verification of IMRT dose distributions from a commercial treatment planning optimization system
Ma C, Pawlicki T, Jiang SB, Li JS, Deng J, Mok E, Kapur A, Xing L, Ma L, Boyer AL. Monte Carlo verification of IMRT dose distributions from a commercial treatment planning optimization system. Physics In Medicine And Biology 2000, 45: 2483-2495. PMID: 11008950, DOI: 10.1088/0031-9155/45/9/303.Peer-Reviewed Original ResearchConceptsMonte Carlo simulationsFinite-size pencil beam (FSPB) algorithmCorvus systemCarlo simulationsOptimization systemIMRT dose distributionsRadiotherapy dose calculationsMonte Carlo treatment planning systemPencil beam algorithmDose distributionMonte CarloBeam algorithmHeterogeneous phantomsMonte Carlo verificationHomogeneous phantomBeam energyCylindrical water phantomIMRT fieldsDose calculationsWater phantomTreatment planning systemField sizeTarget shapeAlgorithmSimulationsEnergy- and intensity-modulated electron beams for radiotherapy
Ma C, Pawlicki T, Lee MC, Jiang SB, Li JS, Deng J, Yi B, Mok E, Boyer AL. Energy- and intensity-modulated electron beams for radiotherapy. Physics In Medicine And Biology 2000, 45: 2293-2311. PMID: 10958195, DOI: 10.1088/0031-9155/45/8/316.Peer-Reviewed Original ResearchConceptsModulated electron radiotherapyIntensity-modulated electron beamElectron beamMultileaf collimatorElectron beam energyInter-leaf leakageDose distributionElectron intraMonte Carlo dose calculationsPencil beam algorithmLeaf endsBeam energyPhoton beamsElectron radiotherapyOblique incidencePatient surfaceMonte Carlo methodBeamBeam algorithmField shapeMonte Carlo simulationsDose calculationsSuperficial targetsCarlo methodCarlo simulationsPhoton beam characterization and modelling for Monte Carlo treatment planning
Deng J, Jiang S, Kapur A, Li J, Pawlicki T, Ma C. Photon beam characterization and modelling for Monte Carlo treatment planning. Physics In Medicine And Biology 2000, 45: 411-427. PMID: 10701512, DOI: 10.1088/0031-9155/45/2/311.Peer-Reviewed Original ResearchConceptsOriginal phase spacePhase spaceMonte Carlo calculationsPhoton jawsCarlo calculationsMonte Carlo treatment planningSource-surface distanceVarian Clinac 2100CPhase space filesPrimary collimatorMultiple source modelPhoton beamsPlanar fluenceAngular distributionsMV photon beamClinac 2100CField sizeSource modelBeam characterizationDose distributionHeterogeneous phantomsGood agreementBeam characteristicsFlattening filterEnergy spectrumModeling and Commissioning of Clinical Photon Beams for Monte Carlo Treatment Planning
Jiang S, Deng J, Li J, Pawlicki T, Boyer A, Ma C. Modeling and Commissioning of Clinical Photon Beams for Monte Carlo Treatment Planning. 2000, 434-436. DOI: 10.1007/978-3-642-59758-9_164.Peer-Reviewed Original ResearchMCDOSE — A Monte Carlo Dose Calculation Tool for Radiation Therapy Treatment Planning
Ma C, Li J, Pawlicki T, Jiang S, Deng J. MCDOSE — A Monte Carlo Dose Calculation Tool for Radiation Therapy Treatment Planning. 2000, 123-125. DOI: 10.1007/978-3-642-59758-9_45.Peer-Reviewed Original ResearchSource-skin distanceClinical dose verificationTransport of photonsEGS4 user codeDose distributionTreatment planning dose calculationsAccelerator beamsElectron beamBeam modifiersDose verificationRadiation therapy treatment planningTherapy treatment planningPhotonsGantry angleDose calculationsCollimator rotationSkin distanceBeamFinal dose distributionInverse treatment planningPatient geometryCouch anglesTreatment planningOptimization systemUser codeVerification of IMRT dose distributions using a water beam imaging system
Li J, Ozhasoglu C, Deng J, Boyer A, Ma C. Verification of IMRT dose distributions using a water beam imaging system. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society 2000, 2: 1158-1161 vol.2. DOI: 10.1109/iembs.2000.897932.Peer-Reviewed Original ResearchBeam imaging systemDose distributionX-ray beamImaging systemCCD cameraReconstructed dose distributionsMultileaf collimatorScintillator screenScintillation screenScintillation imagesIMRT dose verificationDose verificationIMRT dose distributionsDynamic multileaf collimatorMonte Carlo methodIterative reconstruction algorithmReasonable agreementCarlo methodDose valuesReconstruction algorithmIMRT plansPortable personal computerBeamCollimatorMonte Carlo simulation resultsIncluding setup uncertainty in Monte Carlo dose calculation for IMRT
Pawlicki T, Jiang S, Li J, Deng J, Ma C. Including setup uncertainty in Monte Carlo dose calculation for IMRT. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society 2000, 1: 112-115 vol.1. DOI: 10.1109/iembs.2000.900682.Peer-Reviewed Original ResearchIntensity-modulated radiotherapySetup uncertaintiesNormal tissuesPatient positioning uncertaintiesTherapeutic doseRadiation therapyConcomitant doseClinical casesDose distributionDose calculationsDose homogeneityAUTHORS' CONCLUSIONSTarget coverageCritical structure doseRadiotherapy treatmentDoseMonte Carlo dose calculationsIMRT dose distributionsAuthors' initial results