2020
A Preliminary Simulation Study of Dose-Guided Adaptive Radiotherapy Based on Halcyon MV Cone-Beam CT Images With Retrospective Data From a Phase II Clinical Trial
Huang Y, Wang H, Li C, Hu Q, Liu H, Deng J, Li W, Wang R, Wu H, Zhang Y. A Preliminary Simulation Study of Dose-Guided Adaptive Radiotherapy Based on Halcyon MV Cone-Beam CT Images With Retrospective Data From a Phase II Clinical Trial. Frontiers In Oncology 2020, 10: 574889. PMID: 33134173, PMCID: PMC7550711, DOI: 10.3389/fonc.2020.574889.Peer-Reviewed Original ResearchPhase II clinical trialEvaluation patientsClinical trialsAnatomic changesAdaptive radiotherapyPlanning CTPreliminary clinical dataMVCBCT imagesCone-beam CT imagesTarget dose coverageDeformable image registrationClinical dataDose coverageCT imagesPatientsTarget underdosageFractional doseRetrospective dataTumor siteAdaptive plansDoseCTTarget coverageLocal gamma analysisTrials
2015
Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy
Zhang Y, Wu H, Chen Z, Knisely JP, Nath R, Feng Z, Bao S, Deng J. Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 523-531. PMID: 26460994, DOI: 10.1016/j.ijrobp.2015.06.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAorta, ThoracicBody SizeBreastChildChild, PreschoolCone-Beam Computed TomographyFemaleHeartHumansLungMaleMiddle AgedMonte Carlo MethodOrgans at RiskPhantoms, ImagingPhotonsPrecision MedicineProtonsRadiation DosageRadiography, ThoracicRadiotherapy, Image-GuidedRisk AssessmentSex FactorsSpinal CordThoracic WallThoraxConceptsConcomitant imaging doseThoracic radiation therapyCancer riskRadiation therapyMean dosesCardiac substructuresKilovoltage cone-beamImaging doseAdverse eventsPediatric patientsMedian dosesCancer patientsRight ventricleExtra radiation doseSpinal cordHigh dosesPatientsCone beamPlanning CT imagesChest dimensionsDosesPatient sizeImaging guidanceTherapyDose
2014
SU‐D‐9A‐07: Imaging Dose and Cancer Risk in Image‐Guided Radiotherapy of Cancers
Zhou L, Bai S, Zhang Y, Ming X, Zhang Y, Deng J. SU‐D‐9A‐07: Imaging Dose and Cancer Risk in Image‐Guided Radiotherapy of Cancers. Medical Physics 2014, 41: 123-123. DOI: 10.1118/1.4887923.Peer-Reviewed Original ResearchExcess relative riskCancer riskRed bone marrowImage-guided radiotherapyImaging proceduresBone marrowRadiation doseRelative cancer riskSpecific imaging proceduresClinical benefitRetrospective studyTreatment courseWhole cohortRadiotherapy courseCancer patientsRelative riskLarge dosesPatientsHigh dosesPersonalized imagingDosesAbdominal regionDoseCT simulationTreatment planning
2012
Personalized estimation of dose to red bone marrow and the associated leukaemia risk attributable to pelvic kilo-voltage cone beam computed tomography scans in image-guided radiotherapy
Zhang Y, Yan Y, Nath R, Bao S, Deng J. Personalized estimation of dose to red bone marrow and the associated leukaemia risk attributable to pelvic kilo-voltage cone beam computed tomography scans in image-guided radiotherapy. Physics In Medicine And Biology 2012, 57: 4599-4612. PMID: 22750636, DOI: 10.1088/0031-9155/57/14/4599.Peer-Reviewed Original ResearchConceptsKilo-voltage cone beamRed bone marrowLeukemia riskRBM doseImage-guided radiation therapyTomography scanBone marrowCone beamRadiogenic cancer riskRadiation therapy courseCancer patientsBone densityImage-guided radiotherapyRadiation therapyCancer riskHigh riskPersonalized estimationAnthropometric variablesTherapy courseDoseSubject groupsDosesBone dosesScansPatients
2011
Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Yu JB, Roberts KB, Peschel RE, Nath R. Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e39-e47. PMID: 21489702, DOI: 10.1016/j.ijrobp.2011.01.071.Peer-Reviewed Original ResearchConceptsImage-guided radiotherapyTesticular dosesFull-fan modeProstate cancerFemoral headLess doseCBCT scansHalf-fan modeProstate cancer patientsKilovoltage cone-beamCancer patientsIntensity-modulated radiotherapy (IMRT) treatmentKilovoltage CBCTSuperior-inferior directionCone beamDosesCBCT fieldProstate patientsRectumDoseProstateMore doseRadiotherapy treatmentPatientsRadiotherapy
2009
Monte Carlo Investigation of Stereotactic Radiosurgery of Spinal Metastases
Deng J, Chen Z, Knisely J, Decker R, Chiang V, Nath R. Monte Carlo Investigation of Stereotactic Radiosurgery of Spinal Metastases. IFMBE Proceedings 2009, 25/1: 13-16. DOI: 10.1007/978-3-642-03474-9_4.Peer-Reviewed Original ResearchSpinal metastasesStereotactic radiosurgeryDose-volume histogramsMean doseAnalytical anisotropic algorithmRisk of recurrenceTarget dose coverageDose distributionPencil beam convolutionSpinal cordDose coverageTarget dosePTV doseTreatment planMetastasisHomogeneity indexDoseRadiosurgeryPBC resultsPatientsTreatment planning systemPatient anatomyCommercial treatment planning systemDose discrepanciesAccurate dose distribution
2007
On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplants
2003
Dose correlation for thoracic motion in radiation therapy of breast cancer
Ding M, Li J, Deng J, Fourkal E, Ma C. Dose correlation for thoracic motion in radiation therapy of breast cancer. Medical Physics 2003, 30: 2520-2529. PMID: 14528974, DOI: 10.1118/1.1603744.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsBreast NeoplasmsHumansMammographyMotionMovementOnline SystemsPhantoms, ImagingRadiographic Image Interpretation, Computer-AssistedRadiography, ThoracicRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsRespirationSensitivity and SpecificityStatistics as TopicThoraxTomography, X-Ray ComputedConceptsBreathing patternDose correlationBreast cancerChest wall motionChest wall movementPatient's breathing patternDose dataRadiation therapyThoracic motionRadiotherapy treatmentTreatment planningExpiration phaseDifferent breathing phasesFinal dose distributionCancerBreathing phasesPatient anatomyWall motionTreatmentDose distributionCT dataBreathing levelTherapyDosePatient geometry
2001
The MLC tongue-and-groove effect on IMRT dose distributions
Deng J, Pawlicki T, Chen Y, Li J, Jiang S, Ma C. The MLC tongue-and-groove effect on IMRT dose distributions. Physics In Medicine And Biology 2001, 46: 1039-1060. PMID: 11324950, DOI: 10.1088/0031-9155/46/4/310.Peer-Reviewed Original Research
2000
Modulated Electron Beams for Treatment of Breast Cancer
Ma C, Pawlicki T, Lee M, Jiang S, Li J, Deng J, Yi B, Mok E, Boyer A. Modulated Electron Beams for Treatment of Breast Cancer. 2000, 173-175. DOI: 10.1007/978-3-642-59758-9_64.Peer-Reviewed Original ResearchContralateral breastBreast cancer treatmentChest wall treatmentSuch conventional treatmentHigh-dose volumeTangential photon fieldsTumor locationBreast cancerSecondary cancersEffective modalityRadiation therapyLow doseConventional treatmentNormal tissuesCancer treatmentPatient sizeMajor causeLungDoseTreatmentNormal structureCancerBreastHeartScatter doseIncluding setup uncertainty in Monte Carlo dose calculation for IMRT
Pawlicki T, Jiang S, Li J, Deng J, Ma C. Including setup uncertainty in Monte Carlo dose calculation for IMRT. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society 2000, 1: 112-115 vol.1. DOI: 10.1109/iembs.2000.900682.Peer-Reviewed Original ResearchIntensity-modulated radiotherapySetup uncertaintiesNormal tissuesPatient positioning uncertaintiesTherapeutic doseRadiation therapyConcomitant doseClinical casesDose distributionDose calculationsDose homogeneityAUTHORS' CONCLUSIONSTarget coverageCritical structure doseRadiotherapy treatmentDoseMonte Carlo dose calculationsIMRT dose distributionsAuthors' initial results