2009
Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit
Croda J, Croda M, Neves A, dos Santos S. Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit. Critical Care Medicine 2009, 37: 1605-1611. PMID: 19325488, PMCID: PMC4143892, DOI: 10.1097/ccm.0b013e31819da8c7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBrazilCohort StudiesConfidence IntervalsCritical CareCritical IllnessDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHIV InfectionsHospital MortalityHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioProportional Hazards ModelsRetrospective StudiesRisk AssessmentSurvival AnalysisConceptsIntensive care unitAntiretroviral therapyICU admissionCare unitChronic Health Evaluation II scoreHuman immunodeficiency virus-infected patientsCD4 T-cell countUse of ARTTertiary care teaching hospitalMultivariate logistic regression analysisCox proportional hazards modelAcute illness severityRetrospective cohort studyT-cell countsVirus-infected patientsDay of admissionHuman immunodeficiency virusCause of admissionProportional hazards modelPotential confounding factorsLogistic regression analysisAcute PhysiologyICU mortalityII scoreCohort study
2007
The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis
Silva É, Medeiros MA, McBride AJ, Matsunaga J, Esteves GS, Ramos JG, Santos CS, Croda J, Homma A, Dellagostin OA, Haake DA, Reis MG, Ko AI. The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Vaccine 2007, 25: 6277-6286. PMID: 17629368, PMCID: PMC1994161, DOI: 10.1016/j.vaccine.2007.05.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial ProteinsBacterial VaccinesCricetinaeDisease Models, AnimalDrug Administration ScheduleImmunoglobulinsLeptospiraLeptospirosisMesocricetusTime FactorsConceptsMajor public health problemRobust antibody responseGolden Syrian hamstersPublic health problemPotential intervention strategiesLethal inoculumSurface-exposed determinantsProtective immunityAntibody responseSterilizing immunityLethal infectionHamster modelVaccine candidatesSubunit vaccineCompanion animalsHealth problemsVeterinary diseasesSyrian hamstersLeptospiral immunoglobulin-like (Lig) proteinsLeptospira interrogansLeptospirosisL. interrogansIntervention strategiesVirulence factorsImmunoglobulin-like protein