2024
Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
dos Santos P, Messina N, de Oliveira R, da Silva P, Puga M, Dalcolmo M, dos Santos G, de Lacerda M, Jardim B, de Almeida e Val F, Curtis N, Andrews J, Croda J. Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial. The Lancet Infectious Diseases 2024, 24: 594-601. PMID: 38423021, PMCID: PMC11111441, DOI: 10.1016/s1473-3099(23)00818-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultBCG VaccineBrazilFemaleHealth PersonnelHumansInterferon-gamma Release TestsMaleMiddle AgedMycobacterium tuberculosisTuberculosis, PulmonaryVaccinationYoung AdultConceptsQuantiFERON-TB GoldPlacebo groupEffect of BCG vaccinationBCG vaccinationBCG groupBCG-DenmarkHealth-care workersNegative baseline resultsMonths of treatmentMycobacterium tuberculosis infectionAdult pulmonary tuberculosisQuantiFERON-TBMedian ageRandomised controlled trialsPulmonary tuberculosisNo significant differenceEfficacy outcomesTuberculosis infectionClinical trialsControlled trialsEffect of vaccinationTreatment drugsTuberculosis preventionSubstudySignificant differenceThe impact of sputum quality on Xpert positivity in active case-finding for TB
Oliveira da Silva B, Salindri A, Gonçalves T, Cunha E, da Silva Santos A, dos Santos P, Lemes I, Silva D, da Silva Oliveira V, Croda J, de Oliveira R, Andrews J. The impact of sputum quality on Xpert positivity in active case-finding for TB. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 29-36. PMID: 38178289, DOI: 10.5588/ijtld.23.0244.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesHumansMycobacterium tuberculosisSensitivity and SpecificitySputumTuberculosis, PulmonaryConceptsSputum qualityXpert-positiveCase findingChest X-rayLog-binomial regressionCross-sectional analysisMass screening programmeActive case findingCurrent smokingParticipant characteristicsScreening programmeSymptom screeningStandardised questionnaireSpot sputum samplesBlood-stained sputumAbnormal chest radiographBinomial regressionCAD4TBSputum appearanceMucopurulent sputumXpert testingSputum samplesClinical characteristicsSalivary specimensChest radiographs
2023
Delay in the diagnosis and treatment of tuberculosis in prisons in Mato Grosso do Sul, Brazil
Ribeiro C, da Silva Santos A, Tshua D, de Oliveira R, Lemos E, Bourdillon P, Laranjeira A, Gonçalves C, Andrews J, Ko A, Croda J. Delay in the diagnosis and treatment of tuberculosis in prisons in Mato Grosso do Sul, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0015-2023. PMID: 37493729, PMCID: PMC10367220, DOI: 10.1590/0037-8682-0015-2023.Peer-Reviewed Original ResearchConceptsSymptom onsetFirst symptomsLargest male prisonPrison medical recordsTB case dataRetrospective cohort studyPulmonary TB casesYear of diagnosisStart of treatmentTreatment of TBTreatment of tuberculosisNumber of symptomsAverage timePercentage of cureProvider delayTB casesCohort studyTreatment initiationHIV statusSmoking statusTuberculosis casesTB transmissionFirst consultationPatient delayMedical records
2022
Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox G, Carvalho A, Chan P, Croda J, Hill P, Lopez-Varela E, Donkor S, Fielding K, Graham S, Espinal M, Kampmann B, Reingold A, Huerga H, Villalba J, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm J, Seddon J, Whalen C, García-Basteiro A, Triasih R, Chen C, Singh J, Huang L, Sharma S, Hannoun D, Del Corral H, Mandalakas A, Malone L, Ling D, Kritski A, Stein C, Vashishtha R, Boulahbal F, Fang C, Boom W, Netto E, Lemos A, Hesseling A, Kay A, Jones-López E, Horsburgh C, Lange C, Andrews J. Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis. The Lancet Global Health 2022, 10: e1307-e1316. PMID: 35961354, PMCID: PMC10406427, DOI: 10.1016/s2214-109x(22)00283-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBCG VaccineChildChild, PreschoolHumansInfantInfant, NewbornRetrospective StudiesTuberculosisTuberculosis, PulmonaryVaccinationConceptsInfant BCG vaccinationBCG vaccinationExtrapulmonary tuberculosisCohort studyIndividual participant dataPulmonary tuberculosisParticipant dataSystematic reviewIndividual-level participant dataPositive tuberculin skin testMultivariable logistic regression analysisTuberculin skin testTuberculosis infection statusParticipant-level dataLogistic regression analysisAge-specific impactStudy-level random effectWeb of ScienceIncident tuberculosisPrevious tuberculosisTuberculosis developmentSecondary outcomesTuberculosis contactsPrimary outcomeSkin testTuberculosis in prison inmates in Southern Brazil: investigating the epidemiological and operational indicators
Busatto C, Mespaque J, Schwarzbold P, de Souza C, Jarczewski C, Meucci R, Andrews J, Croda J, da Silva P, Ramis I, Possuelo L. Tuberculosis in prison inmates in Southern Brazil: investigating the epidemiological and operational indicators. Revista Da Sociedade Brasileira De Medicina Tropical 2022, 55: e0052-2022. PMID: 36287468, PMCID: PMC9592108, DOI: 10.1590/0037-8682-0052-2022.Peer-Reviewed Original ResearchConceptsPulmonary tuberculosis casesTuberculosis casesPulmonary tuberculosisLaboratory confirmationNew casesNew pulmonary tuberculosis casesRetreatment pulmonary tuberculosis casesWorldwide public health problemNotifiable Diseases Information SystemNew TB casesPublic health problemPublic health measuresTB casesHIV testingTuberculosis controlLaboratory criteriaTuberculosis incidenceIncidence rateObservational studyHealth problemsHealth measuresTuberculosisSpecific populationsHIVInvestigation rates
2021
A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment.
Verma R, Patil S, Zhang N, Moreira F, Vitorio M, Santos A, Wallace E, Gnanashanmugam D, Persing D, Savic R, Croda J, Andrews J. A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 1317-1326. PMID: 34375564, DOI: 10.1164/rccm.202103-0564oc.Peer-Reviewed Original ResearchConceptsPharmacogenomic assaysSparse pharmacokinetic samplingInadequate treatment responseInterindividual pharmacokinetic variabilityAcetylation genotypeIsoniazid clearancePharmacokinetic samplingPulmonary tuberculosisWhole blood samplesIntermediate acetylatorsPharmacokinetic variabilityFast acetylatorsNAT2 polymorphismsAcetylator typeSlow acetylatorsTuberculosis treatmentTreatment responseBlood samplesGeneXpert platformTuberculosis diagnosisVariable drug concentrationsHealthy individualsPersonalized dosingSubstantial incidenceStandardized dosing
2020
Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study
Mancuzo E, Martins E, Sulmonett N, de Souza Viana V, Croda J, Kritski A, de Queiroz Mello F, de Souza Elias Nihues S, Azevedo K, de Miranda S. Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study. Jornal Brasileiro De Pneumologia 2020, 46: e20180198. PMID: 32130330, PMCID: PMC7462712, DOI: 10.36416/1806-3756/e20180198.Peer-Reviewed Original ResearchConceptsPrevious lung diseasePulmonary tuberculosisLung diseaseRadiological changesMulticenter studyRisk factorsLDS groupFunctional severityFunctional changesSevere radiological changesImpaired pulmonary functionRestrictive lung diseaseObstructive lung diseaseDegree of dyspneaChest X-raySpirometric changesSevere dyspneaPulmonary functionReferral centerClinical dataPatientsSpirometryDiseaseDyspneaSmoking
2019
A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols
de Sousa N, Sandström N, Shen L, Håkansson K, Vezozzo R, Udekwu K, Croda J, Rothfuchs A. A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols. Tuberculosis 2019, 120: 101896. PMID: 32090857, PMCID: PMC7049907, DOI: 10.1016/j.tube.2019.101896.Peer-Reviewed Original ResearchConceptsTB hotspotsM. tuberculosisActive pulmonary diseaseAirborne M. tuberculosisElectrostatic air samplerInhalation of aerosolsViable Mycobacterium tuberculosisPulmonary diseaseTB controlTB transmissionM. bovis BCGTuberculosisInfectious diseasesMycobacterium tuberculosisBovis BCGTuberculosis detectionMore human livesMolecular signaturesDiseaseCoughPatientsWorld populationInhalationBCGImportant roleScreening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required
Puga M, Bandeira L, Pompilio M, de Rezende G, Soares L, de Castro V, Tanaka T, Cesar G, de Oliveira S, Teles S, Yassuda R, dos Santos Weis-Torres S, Basílio S, Croda J, Motta-Castro A. Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required. PLOS ONE 2019, 14: e0221265. PMID: 31437184, PMCID: PMC6705821, DOI: 10.1371/journal.pone.0221265.Peer-Reviewed Original ResearchConceptsHepatitis B virusSyphilis infectionViral hepatitisHIV infectionB virusAnti-HCV positive samplesChronic hepatitis B virusFirst-line anti-tuberculosis drugsLifetime syphilis infectionCases of tuberculosisAnti-TB drugsCross-sectional studyPublic health problemAnti-tuberculosis drugsCurrent HCVHCV exposureHCV RNAHepatitis testingTuberculosis infectionActive syphilisSerological markersEpidemiological featuresFrequent causeSide effectsHCVDetection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications
Martinez L, Verma R, Croda J, Horsburgh C, Walter K, Degner N, Middelkoop K, Koch A, Hermans S, Warner D, Wood R, Cobelens F, Andrews J. Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications. European Respiratory Journal 2019, 53: 1802302. PMID: 31048345, PMCID: PMC6753378, DOI: 10.1183/13993003.02302-2018.Peer-Reviewed Original ResearchConceptsInfectious tuberculosis patientsTuberculosis patientsTB transmissionCongregate settingsMouse modelGuinea pigsInfectious threatsMycobacterium tuberculosisDroplet nucleiConsistent findingScientific evidenceInfectious potentialEpidemiological implicationsPrimary routeFurther investigationSeminal experimental studiesRecent studiesHuman sourcesEvidencePatientsTuberculosisFindingsStudyInfectiousnessViabilityEvaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil
Mabud TS, de Lourdes Delgado Alves M, Ko AI, Basu S, Walter KS, Cohen T, Mathema B, Colijn C, Lemos E, Croda J, Andrews JR. Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil. PLOS Medicine 2019, 16: e1002737. PMID: 30677013, PMCID: PMC6345418, DOI: 10.1371/journal.pmed.1002737.Peer-Reviewed Original ResearchConceptsIncidence of TBPrison-based interventionsTB incidenceGeneral populationTB casesCox proportional hazards modelNew TB casesControl of tuberculosisProportional hazards modelPaucity of dataTime of incarcerationTB burdenTB screeningTB riskTB transmissionTB ratesTB epidemicAdministrative databasesCommunity incidenceTuberculosis epidemicHazards modelTB databaseIncidenceEpidemiological contextIntervention
2018
Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners
Maceda EB, Gonçalves C, Andrews JR, Ko AI, Yeckel CW, Croda J. Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners. Scientific Reports 2018, 8: 997. PMID: 29343733, PMCID: PMC5772514, DOI: 10.1038/s41598-018-19589-3.Peer-Reviewed Original ResearchConceptsVitamin D levelsTuberculin skin test conversionPoor vitamin D statusSkin test conversionVitamin D statusActive tuberculosisRisk of progressionCase-control studyD levelsRisk factorsTST conversionD statusCigarette smokingTest conversionSerum vitamin D levelsSubnormal vitamin D levelsMultivariable conditional logistic regressionConditional logistic regressionConsequence of diseaseIncident tuberculosisActive diseaseLatent tuberculosisPrevalent tuberculosisVitamin DBlack race
2016
Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil
Heinrich M, Zembrzuski V, Ota M, Sacchi F, Teixeira R, Acero P, Cunha G, Souza-Santos R, Croda J, Basta P. Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil. Tuberculosis 2016, 101: 15-24. PMID: 27865386, DOI: 10.1016/j.tube.2016.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntitubercular AgentsArylamine N-AcetyltransferaseBrazilChemical and Drug Induced Liver InjuryChildChild, PreschoolCross-Sectional StudiesCytochrome P-450 CYP2E1FemaleGenetic Predisposition to DiseaseGenotypeGlutathione TransferaseHumansIncidenceInfantLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideTuberculosis, PulmonaryYoung AdultConceptsIncidence of hepatotoxicityAdverse drug reactionsIndigenous patientsAnti-TB drug-induced hepatotoxicityNon-conditional logistic regressionClinical-epidemiological factorsClinical-epidemiological variablesNon-Indigenous patientsGenetic polymorphismsRisk of hepatotoxicityDrug-induced hepatotoxicityPolymorphisms of CYP2E1Anti-tuberculosis drugsAcetylation profileTB patientsSerum levelsDrug reactionsGSTM1 polymorphismOdds ratioLiver enzymesNon-Indigenous populationsTherapeutic schemesPharmacogenetic analysisBetter outcomesPatients
2015
Chronic symptoms and pulmonary dysfunction in post-tuberculosis Brazilian patients
de Sousa Elias Nihues S, Mancuzo E, Sulmonetti N, Sacchi F, de Souza Viana V, Netto E, Miranda S, Croda J. Chronic symptoms and pulmonary dysfunction in post-tuberculosis Brazilian patients. The Brazilian Journal Of Infectious Diseases 2015, 19: 492-497. PMID: 26254689, PMCID: PMC9427540, DOI: 10.1016/j.bjid.2015.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrazilChronic DiseaseCross-Sectional StudiesFemaleHumansIndians, South AmericanLungMalePrevalenceRespiration DisordersSpirometryTuberculosis, PulmonaryConceptsChronic respiratory symptomsPulmonary dysfunctionRespiratory symptomsChronic symptomsObstructive disordersPost-tuberculosis patientsPrevious pulmonary diseaseCross-sectional studyPulmonary diseaseRestrictive disordersPulmonary disordersBrazilian patientsHigh prevalenceReportable diseaseFurther interventionDysfunctionSymptomsPatientsPrevalenceLifestyle differencesDisordersAORNon-Indigenous individualsYears of schoolingDiseaseActive and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study
Carbone Ada S, Paião DS, Sgarbi RV, Lemos EF, Cazanti RF, Ota MM, Junior AL, Bampi JV, Elias VP, Simionatto S, Motta-Castro AR, Pompílio MA, de Oliveira SM, Ko AI, Andrews JR, Croda J. Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study. BMC Infectious Diseases 2015, 15: 24. PMID: 25608746, PMCID: PMC4307675, DOI: 10.1186/s12879-015-0764-8.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionPrevalence of LTBITuberculin skin testActive TBLTBI prevalenceWeeks of symptomsHigh transmission settingsCross-sectional studyPopulation-based samplePoisson regression modelsDuration of incarcerationHierarchical Poisson regression modelActive diseaseTB infectionLatent tuberculosisTB casesHIV testingSputum cultureTuberculosis infectionPoint prevalenceSkin testTuberculosis incidenceRisk factorsMultivariable modelSputum samples
2013
Active and latent tuberculosis in prisoners in the Central-West Region of Brazil
Estevan A, de Oliveira S, Croda J. Active and latent tuberculosis in prisoners in the Central-West Region of Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2013, 46: 515-518. PMID: 23904084, DOI: 10.1590/0037-8682-1441-2013.Peer-Reviewed Original Research