2024
The impact of sputum quality on Xpert positivity in active case-finding for TB
Oliveira da Silva B, Salindri A, Gonçalves T, Cunha E, da Silva Santos A, dos Santos P, Lemes I, Silva D, da Silva Oliveira V, Croda J, de Oliveira R, Andrews J. The impact of sputum quality on Xpert positivity in active case-finding for TB. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 29-36. PMID: 38178289, DOI: 10.5588/ijtld.23.0244.Peer-Reviewed Original ResearchConceptsSputum qualityXpert-positiveCase findingChest X-rayLog-binomial regressionCross-sectional analysisMass screening programmeActive case findingCurrent smokingParticipant characteristicsScreening programmeSymptom screeningStandardised questionnaireSpot sputum samplesBlood-stained sputumAbnormal chest radiographBinomial regressionCAD4TBSputum appearanceMucopurulent sputumXpert testingSputum samplesClinical characteristicsSalivary specimensChest radiographs
2021
Pooling Sputum Samples for Efficient Mass Tuberculosis Screening in Prisons
Dos Santos P, da Silva Santos A, de Oliveira R, da Silva B, Soares T, Martinez L, Verma R, Andrews J, Croda J. Pooling Sputum Samples for Efficient Mass Tuberculosis Screening in Prisons. Clinical Infectious Diseases 2021, 74: 2115-2121. PMID: 34718459, PMCID: PMC9258923, DOI: 10.1093/cid/ciab847.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationTuberculosis screeningMycobacterial loadHigh prevalenceSputum samplesMass screeningHigh tuberculosis prevalenceHigh-risk groupHigher mycobacterial loadPositive samplesTuberculosis casesPrevalence settingsTuberculosis prevalenceLow prevalenceSingle positive samplePrevalenceActive casesHealth Organization
2019
Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications
Martinez L, Verma R, Croda J, Horsburgh C, Walter K, Degner N, Middelkoop K, Koch A, Hermans S, Warner D, Wood R, Cobelens F, Andrews J. Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications. European Respiratory Journal 2019, 53: 1802302. PMID: 31048345, PMCID: PMC6753378, DOI: 10.1183/13993003.02302-2018.Peer-Reviewed Original ResearchConceptsInfectious tuberculosis patientsTuberculosis patientsTB transmissionCongregate settingsMouse modelGuinea pigsInfectious threatsMycobacterium tuberculosisDroplet nucleiConsistent findingScientific evidenceInfectious potentialEpidemiological implicationsPrimary routeFurther investigationSeminal experimental studiesRecent studiesHuman sourcesEvidencePatientsTuberculosisFindingsStudyInfectiousnessViability