2023
Scaling up evidence-based approaches to tuberculosis screening in prisons
Charalambous S, Velen K, Rueda Z, Croda J, Herce M, Shenoi S, Altice F, Muyoyeta M, Telisinghe L, Grandjean L, Keshavjee S, Andrews J. Scaling up evidence-based approaches to tuberculosis screening in prisons. The Lancet Public Health 2023, 8: e305-e310. PMID: 36780916, DOI: 10.1016/s2468-2667(23)00002-6.Commentaries, Editorials and LettersConceptsIncidence of tuberculosisCase-finding strategyHigh tuberculosis burdenMinistry of HealthEvidence-based approachTuberculosis burdenTreatment cascadeTuberculosis screeningTuberculosis notificationsTuberculosis diagnosisGeneral populationCare programDiagnostic strategiesTuberculosisEvidence baseSystematic screeningHigh rateIncidenceScreeningSetting
2021
A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment.
Verma R, Patil S, Zhang N, Moreira F, Vitorio M, Santos A, Wallace E, Gnanashanmugam D, Persing D, Savic R, Croda J, Andrews J. A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 1317-1326. PMID: 34375564, DOI: 10.1164/rccm.202103-0564oc.Peer-Reviewed Original ResearchConceptsPharmacogenomic assaysSparse pharmacokinetic samplingInadequate treatment responseInterindividual pharmacokinetic variabilityAcetylation genotypeIsoniazid clearancePharmacokinetic samplingPulmonary tuberculosisWhole blood samplesIntermediate acetylatorsPharmacokinetic variabilityFast acetylatorsNAT2 polymorphismsAcetylator typeSlow acetylatorsTuberculosis treatmentTreatment responseBlood samplesGeneXpert platformTuberculosis diagnosisVariable drug concentrationsHealthy individualsPersonalized dosingSubstantial incidenceStandardized dosing
2018
119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
Warsinske H, Rao A, Moreira F, Dos Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response. Open Forum Infectious Diseases 2018, 5: s5-s5. PMCID: PMC6253029, DOI: 10.1093/ofid/ofy209.010.Peer-Reviewed Original ResearchNegative predictive valueTB scoreWorld Health OrganizationActive tuberculosisATB patientsCohort studyTriage testTreatment responseHigh negative predictive valueProspective cohort studyCase-control trialEnd of treatmentIndependent prospective cohortsAdolescent cohort studySputum positivityActive diseaseProspective cohortTreatment initiationSputum testDisease onsetProspective validationPET-CTPredicting ProgressionTuberculosis diagnosisPredictive value