2022
Evaluation of chest X-ray with automated interpretation algorithms for mass tuberculosis screening in prisons: A cross-sectional study
Soares T, de Oliveira R, Liu Y, da Silva Santos A, dos Santos P, Monte L, de Oliveira L, Park C, Hwang E, Andrews J, Croda J. Evaluation of chest X-ray with automated interpretation algorithms for mass tuberculosis screening in prisons: A cross-sectional study. The Lancet Regional Health - Americas 2022, 17: 100388. PMID: 36776567, PMCID: PMC9904090, DOI: 10.1016/j.lana.2022.100388.Peer-Reviewed Original ResearchChest X-rayWorld Health OrganizationTB screeningPrevious TBInterpretation algorithmsAbnormality scoreXpert MTB/RIFSputum bacillary loadSystematic Tuberculosis ScreeningMultivariable logistic regressionMTB/RIFCross-sectional studyEffective triage toolX-ray imagesTB symptomsClinical characteristicsBacillary loadPrior TBTuberculosis screeningTriage testUS National InstitutesAlgorithm accuracyTriage toolStandardized questionnaireConfirmatory testing
2021
Blood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study
Moreira F, Verma R, dos Santos P, Leite A, da Silva Santos A, de Araujo R, da Silva B, de Sá Queiroz J, Persing D, Södersten E, Gnanashanmugam D, Khatri P, Croda J, Andrews J. Blood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study. EClinicalMedicine 2021, 33: 100776. PMID: 33842866, PMCID: PMC8020164, DOI: 10.1016/j.eclinm.2021.100776.Peer-Reviewed Original ResearchCare C-reactive proteinXpert MTB/RIFMTB/RIFDiagnostic case-control studyXpert MTBCase-control studyTuberculosis casesTriage testSputum Xpert MTB/RIFHigh tuberculosis burden settingsActive casesSputum bacillary burdenC-reactive proteinHigh-burden populationsCulture-confirmed casesMass screening programCulture-negative controlsBacillary burdenTuberculosis symptomsPulmonary tuberculosisSputum cultureScreening program
2018
119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
Warsinske H, Rao A, Moreira F, Dos Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response. Open Forum Infectious Diseases 2018, 5: s5-s5. PMCID: PMC6253029, DOI: 10.1093/ofid/ofy209.010.Peer-Reviewed Original ResearchNegative predictive valueTB scoreWorld Health OrganizationActive tuberculosisATB patientsCohort studyTriage testTreatment responseHigh negative predictive valueProspective cohort studyCase-control trialEnd of treatmentIndependent prospective cohortsAdolescent cohort studySputum positivityActive diseaseProspective cohortTreatment initiationSputum testDisease onsetProspective validationPET-CTPredicting ProgressionTuberculosis diagnosisPredictive valueAssessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohort