Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil
Heinrich M, Zembrzuski V, Ota M, Sacchi F, Teixeira R, Acero P, Cunha G, Souza-Santos R, Croda J, Basta P. Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil. Tuberculosis 2016, 101: 15-24. PMID: 27865386, DOI: 10.1016/j.tube.2016.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntitubercular AgentsArylamine N-AcetyltransferaseBrazilChemical and Drug Induced Liver InjuryChildChild, PreschoolCross-Sectional StudiesCytochrome P-450 CYP2E1FemaleGenetic Predisposition to DiseaseGenotypeGlutathione TransferaseHumansIncidenceInfantLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideTuberculosis, PulmonaryYoung AdultConceptsIncidence of hepatotoxicityAdverse drug reactionsIndigenous patientsAnti-TB drug-induced hepatotoxicityNon-conditional logistic regressionClinical-epidemiological factorsClinical-epidemiological variablesNon-Indigenous patientsGenetic polymorphismsRisk of hepatotoxicityDrug-induced hepatotoxicityPolymorphisms of CYP2E1Anti-tuberculosis drugsAcetylation profileTB patientsSerum levelsDrug reactionsGSTM1 polymorphismOdds ratioLiver enzymesNon-Indigenous populationsTherapeutic schemesPharmacogenetic analysisBetter outcomesPatients