Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment
Vasconcelos N, Vaz M, Radai J, Kassuya C, Formagio A, Graciani F, Leal M, Oliveira R, da Silva K, Croda J, Simionatto S. Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment. Journal Of Toxicology And Environmental Health Part A 2020, 83: 719-729. PMID: 32981476, DOI: 10.1080/15287394.2020.1824135.Peer-Reviewed Original ResearchConceptsSwiss male miceMultidrug-resistant strainsSplenic phagocytosisMale miceAgar disk diffusionBeneficial effectsToxicological assessmentMicronucleus assayKlebsiella pneumoniaePlant extractsVivo toxicological assessmentDisk diffusionAntibioticsAntimicrobial activityMutagenic activityGlobal spreadExtractMolecular characterizationAssessmentAntibacterial activityActivityMiceActive productsSynergismAntibacterial activity and synergism of the essential oil of Nectandra megapotamica (L.) flowers against OXA-23-producing Acinetobacter baumannii
Vasconcelos N, Mallmann V, Costa É, Simionatto E, Coutinho E, Da Silva R, Ribeiro S, Franco O, Migliolo L, Croda J, Simionatto S. Antibacterial activity and synergism of the essential oil of Nectandra megapotamica (L.) flowers against OXA-23-producing Acinetobacter baumannii. Journal Of Essential Oil Research 2020, 32: 260-268. DOI: 10.1080/10412905.2020.1740802.Peer-Reviewed Original ResearchGas chromatography/mass spectrometry analysisChromatography/mass spectrometry analysisGas chromatography/flame ionization detectorNatural plant essential oilsDrug delivery systemsAntibacterial activityEssential oilMass spectrometry analysisFlame ionization detectorSpectrometry analysisChemical compositionDelivery systemAntimicrobial activityIonization detectorBiological propertiesSynergistic effectOxygenated sesquiterpenesCaryophyllene oxideNew drug developmentOilPlant essential oilsDrug developmentExcipientsOxideAntibacterial activity of Cinnamomum cassia L. essential oil in a carbapenem- and polymyxin-resistant Klebsiella aerogenes strain
Vasconcelos N, Silva K, Croda J, Simionatto S. Antibacterial activity of Cinnamomum cassia L. essential oil in a carbapenem- and polymyxin-resistant Klebsiella aerogenes strain. Revista Da Sociedade Brasileira De Medicina Tropical 2020, 53: e20200032. PMID: 33027413, PMCID: PMC7534965, DOI: 10.1590/0037-8682-0032-2020.Peer-Reviewed Original ResearchConceptsHigh antibiotic resistanceMultidrug resistance profilesTime-kill methodsBla OXA-1Multidrug-resistant bacteriaMinimum inhibitory concentrationBla TEMBla CTXAntibacterial activityInhibitory effectBroth microdilutionInhibitory concentrationAntibiotic resistanceK. aerogenesOXA-1KPC-2CarbapenemsCinnamomum cassia essential oilL. essential oilCassia essential oilEssential oilCTXActivity