2018
119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response
Warsinske H, Rao A, Moreira F, Dos Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response. Open Forum Infectious Diseases 2018, 5: s5-s5. PMCID: PMC6253029, DOI: 10.1093/ofid/ofy209.010.Peer-Reviewed Original ResearchNegative predictive valueTB scoreWorld Health OrganizationActive tuberculosisATB patientsCohort studyTriage testTreatment responseHigh negative predictive valueProspective cohort studyCase-control trialEnd of treatmentIndependent prospective cohortsAdolescent cohort studySputum positivityActive diseaseProspective cohortTreatment initiationSputum testDisease onsetProspective validationPET-CTPredicting ProgressionTuberculosis diagnosisPredictive valueSerum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners
Maceda EB, Gonçalves C, Andrews JR, Ko AI, Yeckel CW, Croda J. Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners. Scientific Reports 2018, 8: 997. PMID: 29343733, PMCID: PMC5772514, DOI: 10.1038/s41598-018-19589-3.Peer-Reviewed Original ResearchConceptsVitamin D levelsTuberculin skin test conversionPoor vitamin D statusSkin test conversionVitamin D statusActive tuberculosisRisk of progressionCase-control studyD levelsRisk factorsTST conversionD statusCigarette smokingTest conversionSerum vitamin D levelsSubnormal vitamin D levelsMultivariable conditional logistic regressionConditional logistic regressionConsequence of diseaseIncident tuberculosisActive diseaseLatent tuberculosisPrevalent tuberculosisVitamin DBlack race
2015
Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study
Carbone Ada S, Paião DS, Sgarbi RV, Lemos EF, Cazanti RF, Ota MM, Junior AL, Bampi JV, Elias VP, Simionatto S, Motta-Castro AR, Pompílio MA, de Oliveira SM, Ko AI, Andrews JR, Croda J. Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study. BMC Infectious Diseases 2015, 15: 24. PMID: 25608746, PMCID: PMC4307675, DOI: 10.1186/s12879-015-0764-8.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionPrevalence of LTBITuberculin skin testActive TBLTBI prevalenceWeeks of symptomsHigh transmission settingsCross-sectional studyPopulation-based samplePoisson regression modelsDuration of incarcerationHierarchical Poisson regression modelActive diseaseTB infectionLatent tuberculosisTB casesHIV testingSputum cultureTuberculosis infectionPoint prevalenceSkin testTuberculosis incidenceRisk factorsMultivariable modelSputum samples
2013
Impact of Latent Infection Treatment in Indigenous Populations
Yuhara L, Sacchi F, Croda J. Impact of Latent Infection Treatment in Indigenous Populations. PLOS ONE 2013, 8: e71201. PMID: 23936264, PMCID: PMC3729554, DOI: 10.1371/journal.pone.0071201.Peer-Reviewed Original ResearchConceptsSmear-positive index casesTuberculin skin testActive tuberculosisLatent infectionIndex caseInfection treatmentLatent tuberculosisActive diseaseTuberculosis contactsRetrospective studySkin testClinical recordsRisk factorsNotification databaseMultidisciplinary teamClose contactTuberculosisInfectionTreatmentAgeEstimated numberPresent studyMorbidityIndigenous BraziliansCasesActive and latent tuberculosis in prisoners in the Central-West Region of Brazil
Estevan A, de Oliveira S, Croda J. Active and latent tuberculosis in prisoners in the Central-West Region of Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2013, 46: 515-518. PMID: 23904084, DOI: 10.1590/0037-8682-1441-2013.Peer-Reviewed Original ResearchGenetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
Longhi R, Zembrzuski V, Basta P, Croda J. Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review. The Brazilian Journal Of Infectious Diseases 2013, 17: 363-368. PMID: 23665009, PMCID: PMC9427389, DOI: 10.1016/j.bjid.2012.11.001.Peer-Reviewed Original ResearchConceptsImmune responseCytokine expressionGenetic polymorphismsHigher IL-5 productionTh2-type responseIL-5 productionTuberculin skin testIFN-γ productionRelevant genetic polymorphismsActive diseaseTB infectionCytokine levelsLower TNFHigh IgG4IgM levelsIL-12p40Skin testImmunogenetic mechanismsImmune regulationInclusion criteriaNew treatmentsMajority of studiesTuberculosisSearch termsIndigenous populations