2023
Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality
Zogg C, Cooper Z, Peduzzi P, Falvey J, Castillo-Angeles M, Kodadek L, Staudenmayer K, Davis K, Tinetti M, Lichtman J. Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality. JAMA Surgery 2023, 158: e234856. PMID: 37792354, PMCID: PMC10551815, DOI: 10.1001/jamasurg.2023.4856.Peer-Reviewed Original ResearchConceptsHospital-level factorsTraumatic brain injurySevere traumatic brain injuryHospital mortalityTrauma QualityOlder adultsHip fractureComposite scoreHigher risk-adjusted oddsLevel 1 trauma centerIn-Hospital MortalityRisk-adjusted oddsLong-term outcomesMultivariable logistic regressionNontrauma centersTrauma patientsTerm outcomesTrauma centerPrimary diagnosisBrain injuryTrauma systemMAIN OUTCOMEMedicare feeService claimsForms of traumaOutcomes after ischemic stroke for dual-eligible Medicare-Medicaid beneficiaries in the United States
Leifheit E, Wang Y, Goldstein L, Lichtman J. Outcomes after ischemic stroke for dual-eligible Medicare-Medicaid beneficiaries in the United States. PLOS ONE 2023, 18: e0292546. PMID: 37797070, PMCID: PMC10553827, DOI: 10.1371/journal.pone.0292546.Peer-Reviewed Original ResearchConceptsStroke hospitalization ratesMedicare beneficiariesIschemic strokeHospitalization ratesUS acute care hospitalsDual-eligible patientsLong-term mortalityUS Medicare beneficiariesIschemic stroke hospitalizationsPost-stroke outcomesAcute care hospitalsService Medicare beneficiariesDual-eligible statusDual-eligible beneficiariesPercentage of beneficiariesCause readmissionHigher readmissionClinical factorsDual eligibilityAdjusted analysisPoor outcomeStroke patientsCox regressionStroke hospitalizationsPrincipal diagnosisAssociation of short-term hospital-level outcome metrics with 1-year mortality and recurrence for US Medicare beneficiaries with ischemic stroke
Wang Y, Leifheit E, Goldstein L, Lichtman J. Association of short-term hospital-level outcome metrics with 1-year mortality and recurrence for US Medicare beneficiaries with ischemic stroke. PLOS ONE 2023, 18: e0289790. PMID: 37561680, PMCID: PMC10414659, DOI: 10.1371/journal.pone.0289790.Peer-Reviewed Original ResearchConceptsIschemic strokeInverse probability weightsStroke patientsCause mortalityOutcome metricsLower riskUS hospitalsBetter long-term outcomesRecurrent stroke rateIschemic stroke recurrenceIschemic stroke patientsLong-term outcomesUS Medicare beneficiariesPerformance categoriesIntermediate hospitalsRecurrent strokeStroke recurrenceCohort studyClinical factorsRecurrence ratePrincipal diagnosisPatient riskStroke rateReadmission measuresCox modelAssociations Between Long-Term Air Pollutant Exposure and 30-Day All-Cause Hospital Readmissions in US Patients With Stroke
Tran P, Warren J, Leifheit E, Goldstein L, Lichtman J. Associations Between Long-Term Air Pollutant Exposure and 30-Day All-Cause Hospital Readmissions in US Patients With Stroke. Stroke 2023, 54: e126-e129. PMID: 36729388, PMCID: PMC11059199, DOI: 10.1161/strokeaha.122.042265.Peer-Reviewed Original ResearchConceptsLong-term air pollutant exposureAir pollutant exposureCause hospital readmissionHospital readmissionPollutant exposureMedicare beneficiaries agePerformance categoriesMatter 2.5Sulfur dioxide exposureCause readmission measureIschemic strokeStroke incidenceUS patientsHospital characteristicsSD increaseReadmissionCox modelReadmission measuresBeneficiaries ageLong-term exposureStrokePatientsMedicaid ServicesParticulate matter 2.5US fee
2015
2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardiovascular Endpoints Data Standards)
Hicks K, Tcheng J, Bozkurt B, Chaitman B, Cutlip D, Farb A, Fonarow G, Jacobs J, Jaff M, Lichtman J, Limacher M, Mahaffey K, Mehran R, Nissen S, Smith E, Targum S. 2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardiovascular Endpoints Data Standards). Journal Of Nuclear Cardiology 2015, 22: 1041-1144. PMID: 26204990, DOI: 10.1007/s12350-015-0209-1.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Heart AssociationCardiologyCardiovascular DiseasesClinical Trials as TopicCommon Data ElementsConfidentialityDatabases, FactualEndpoint DeterminationHealth Insurance Portability and Accountability ActHumansQuality Assurance, Health CareQuality of Health CareReproducibility of ResultsResearch DesignSocieties, MedicalTerminology as TopicTranslational Research, BiomedicalTreatment OutcomeUnited States
2012
30-Day Risk-Standardized Mortality and Readmission Rates After Ischemic Stroke in Critical Access Hospitals
Lichtman JH, Leifheit-Limson EC, Jones SB, Wang Y, Goldstein LB. 30-Day Risk-Standardized Mortality and Readmission Rates After Ischemic Stroke in Critical Access Hospitals. Stroke 2012, 43: 2741-2747. PMID: 22935397, PMCID: PMC3547601, DOI: 10.1161/strokeaha.112.665646.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesRisk-standardized readmission ratesAnnual hospital volumeIschemic strokeReadmission ratesHospital volumeVolume quartileHighest risk-standardized mortality ratesPoor short-term outcomeMedicare beneficiaries 65 yearsService Medicare beneficiaries 65 yearsHighest volume quartileHospital volume quartilesPrimary discharge diagnosisLow-volume hospitalsShort-term outcomesBeneficiaries 65 years
2011
30-Day Mortality and Readmission After Hemorrhagic Stroke Among Medicare Beneficiaries in Joint Commission Primary Stroke Center-Certified and Noncertified Hospitals
Lichtman JH, Jones SB, Leifheit-Limson EC, Wang Y, Goldstein LB. 30-Day Mortality and Readmission After Hemorrhagic Stroke Among Medicare Beneficiaries in Joint Commission Primary Stroke Center-Certified and Noncertified Hospitals. Stroke 2011, 42: 3387-3391. PMID: 22033986, PMCID: PMC3292255, DOI: 10.1161/strokeaha.111.622613.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhageIntracerebral hemorrhageReadmission ratesHemorrhagic strokeMedicare beneficiariesJoint Commission Primary Stroke CentersLower risk-adjusted mortality ratesCox proportional hazards regressionRisk-adjusted readmission ratesRisk-adjusted mortality ratesIschemic stroke patientsPrimary discharge diagnosisPrimary stroke centerProportional hazards regressionService Medicare beneficiariesEffects of careHospital mortalityStroke centersStroke patientsDischarge diagnosisHazards regressionMortality rateBetter outcomesHospitalPatientsOutcomes after ischemic stroke for hospitals with and without Joint Commission–certified primary stroke centers
Lichtman JH, Jones SB, Wang Y, Watanabe E, Leifheit-Limson E, Goldstein LB. Outcomes after ischemic stroke for hospitals with and without Joint Commission–certified primary stroke centers. Neurology 2011, 76: 1976-1982. PMID: 21543736, PMCID: PMC3109877, DOI: 10.1212/wnl.0b013e31821e54f3.Peer-Reviewed Original ResearchConceptsPrimary stroke centerRisk-standardized mortalityJoint CommissionPSC hospitalsIschemic strokeReadmission ratesStroke centersService Medicare beneficiariesHospital referral regionsIschemic stroke dischargesPSC certificationPatient demographicsComorbid conditionsStudy cohortMortality outcomesNational averagePrimary diagnosisReferral regionsMedicare beneficiariesHierarchical linear regression modelsHospitalStroke dischargesLinear regression modelsLower ratesStroke
2010
Trends in One-Year Recurrent Ischemic Stroke among the Elderly in the USA: 1994–2002
Allen NB, Holford TR, Bracken MB, Goldstein LB, Howard G, Wang Y, Lichtman JH. Trends in One-Year Recurrent Ischemic Stroke among the Elderly in the USA: 1994–2002. Cerebrovascular Diseases 2010, 30: 525-532. PMID: 20881382, PMCID: PMC2978738, DOI: 10.1159/000319028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overFee-for-Service PlansFemaleHumansMaleMedicareRecurrenceRetrospective StudiesStrokeUnited StatesThe Role of Social Support in Health Status and Depressive Symptoms After Acute Myocardial Infarction
Leifheit-Limson EC, Reid KJ, Kasl SV, Lin H, Jones PG, Buchanan DM, Parashar S, Peterson PN, Spertus JA, Lichtman JH. The Role of Social Support in Health Status and Depressive Symptoms After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2010, 3: 143-150. PMID: 20160162, PMCID: PMC3016989, DOI: 10.1161/circoutcomes.109.899815.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisChi-Square DistributionDepressionEvidence-Based MedicineFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProspective StudiesQuality of LifeRegistriesRisk AssessmentRisk FactorsSex FactorsSocial SupportTime FactorsUnited StatesWomen's HealthWomen's Health ServicesConceptsAcute myocardial infarctionLow social supportDisease-specific qualityDepressive symptomsMyocardial infarctionHealth statusPhysical functioningLower disease-specific qualitySocial supportBaseline health statusBaseline depressive symptomsWorse health statusRisk of anginaLower physical functioningMyocardial infarction recoverySex-stratified associationsLower mental functioningSex-stratified analysesMore depressive symptomsFirst yearClinical factorsProspective studyNonsignificant trendSymptomsInfarction
2009
Hospital Arrival Time and Intravenous t-PA Use in US Academic Medical Centers, 2001–2004
Lichtman JH, Watanabe E, Allen NB, Jones SB, Dostal J, Goldstein LB. Hospital Arrival Time and Intravenous t-PA Use in US Academic Medical Centers, 2001–2004. Stroke 2009, 40: 3845-3850. PMID: 19797697, DOI: 10.1161/strokeaha.109.562660.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedAged, 80 and overBlack or African AmericanBrain IschemiaEmergency Medical ServicesEmergency Service, HospitalFemaleHealth Services AccessibilityHumansInjections, IntravenousIntracranial ThrombosisMaleMiddle AgedQuality of Health CareSeverity of Illness IndexStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTransportation of PatientsUnited StatesWhite PeopleConceptsIschemic stroke patientsSymptom onsetT-PA useStroke patientsHospital arrivalIntravenous tissue-type plasminogen activatorConsecutive ischemic stroke patientsEarly hospital arrivalPercentage of patientsUS academic centersHospital arrival timeRisk-adjusted analysisMultivariate logistic regressionCare-seeking behaviorAcademic medical centerTissue-type plasminogen activatorClinical characteristicsSevere strokePatient characteristicsBlack patientsEmergency departmentMedical recordsHospital careMedical CenterLower oddsStroke Patient Outcomes in US Hospitals Before the Start of the Joint Commission Primary Stroke Center Certification Program
Lichtman JH, Allen NB, Wang Y, Watanabe E, Jones SB, Goldstein LB. Stroke Patient Outcomes in US Hospitals Before the Start of the Joint Commission Primary Stroke Center Certification Program. Stroke 2009, 40: 3574-3579. PMID: 19797179, PMCID: PMC2782858, DOI: 10.1161/strokeaha.109.561472.Peer-Reviewed Original ResearchConceptsPrimary stroke centerCross-sectional studyBetter outcomesJoint CommissionHospital mortalityStroke centersCox proportional hazards modelStroke center certificationStroke patient outcomesProportional hazards modelYears of ageHierarchical logistic regressionIschemic strokeCenter certificationPatient outcomesMedicare feeHazards modelUS hospitalsService beneficiariesHospitalLogistic regressionPatientsMortalityRisk adjustmentStudy sampleDiagnostic Evaluation for Patients with Ischemic Stroke: Are There Sex Differences?
Watanabe E, Allen NB, Dostal J, Sama D, Claus EB, Goldstein LB, Lichtman JH. Diagnostic Evaluation for Patients with Ischemic Stroke: Are There Sex Differences? Cerebrovascular Diseases 2009, 27: 450-455. PMID: 19295208, DOI: 10.1159/000209240.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsStroke patientsIschemic strokeAcademic hospitalDiagnostic evaluationConsecutive ischemic stroke patientsDiagnostic testsAcute coronary symptomsCarotid artery ultrasoundManagement of womenUS academic medical centersMultivariate logistic regressionUse of neuroimagingAcademic medical centerUS academic hospitalsSex-associated differencesSex differencesClinical factorsCoronary symptomsPotential confoundersMedical recordsCarotid arteryMedical CenterPatientsLogistic regressionElderly Women Have Lower Rates of Stroke, Cardiovascular Events, and Mortality After Hospitalization for Transient Ischemic Attack
Lichtman JH, Jones SB, Watanabe E, Allen NB, Wang Y, Howard VJ, Goldstein LB. Elderly Women Have Lower Rates of Stroke, Cardiovascular Events, and Mortality After Hospitalization for Transient Ischemic Attack. Stroke 2009, 40: 2116-2122. PMID: 19228857, PMCID: PMC2757938, DOI: 10.1161/strokeaha.108.543009.Peer-Reviewed Original ResearchConceptsTransient ischemic attackCoronary artery diseaseArtery diseaseIschemic attackCardiovascular eventsOutcomes 30 daysService Medicare patientsRisk-adjusted analysisProportional hazards modelYears of ageRandom effects logistic modelSex-related differencesSex-based differencesCardiac comorbiditiesTIA admissionsCause readmissionElderly patientsHospital dischargePrior hospitalizationBetter prognosisUnadjusted ratesMedical historyElderly womenMedicare patientsHazards modelThe joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction
Champney K, Frederick P, Bueno H, Parashar S, Foody J, Merz C, Canto J, Lichtman J, Vaccarino V, Investigators F. The joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction. Heart 2009, 95: 895. PMID: 19147625, PMCID: PMC3065924, DOI: 10.1136/hrt.2008.155804.Peer-Reviewed Original ResearchConceptsNon-ST elevation MIST-elevation MIElevation myocardial infarctionMyocardial infarctionNSTEMI patientsNon-ST elevation myocardial infarctionST-elevation myocardial infarctionRetrospective cohort studyExcess mortality riskShort-term mortalityAcute myocardial infarctionSex-related differencesHospital mortalityUnadjusted RRHospital deathCohort studyPatient ageExcess riskNational registryHospital participantsMAIN OUTCOMEMortality riskOlder womenAge 50Better survival
2008
Depression and Coronary Heart Disease
Lichtman JH, Bigger JT, Blumenthal JA, Frasure-Smith N, Kaufmann PG, Lespérance F, Mark DB, Sheps DS, Taylor CB, Froelicher ES. Depression and Coronary Heart Disease. Circulation 2008, 118: 1768-1775. PMID: 18824640, DOI: 10.1161/circulationaha.108.190769.Peer-Reviewed Original Research
2001
Utilization of Intravenous Tissue-Type Plasminogen Activator for Ischemic Stroke at Academic Medical Centers
Johnston S, Fung L, Gillum L, Smith W, Brass L, Lichtman J, Brown A. Utilization of Intravenous Tissue-Type Plasminogen Activator for Ischemic Stroke at Academic Medical Centers. Stroke 2001, 32: 1061-1068. PMID: 11340210, DOI: 10.1161/01.str.32.5.1061.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedBlack or African AmericanBrain IschemiaCohort StudiesContraindicationsDatabases, FactualDrug Utilization ReviewFemaleFibrinolytic AgentsHumansLogistic ModelsMaleMiddle AgedPatient DischargeStrokeThrombolytic TherapyTissue Plasminogen ActivatorUnited StatesWhite PeopleConceptsAcademic medical centerTissue-type plasminogen activatorIschemic strokeMedical CenterIntravenous tissue-type plasminogen activatorConsecutive ischemic stroke casesAfrican AmericansPlasminogen activatorIschemic stroke patientsUS academic medical centersMultivariable logistic regressionMedical insuranceIschemic stroke casesMedical insurance typePrivate medical insuranceTPA useStroke severityStroke patientsStroke casesMedical historyInsurance typeMedical recordsUnivariate analysisContraindicationsLogistic regression
1996
The NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study: Background and Methodology
LAHEY B, FLAGG E, BIRD H, SCHWAB-STONE M, CANINO G, DULCAN M, LEAF P, DAVIES M, BROGAN D, BOURDON K, HORWITZ S, RUBIO-STIPEC M, FREEMAN D, LICHTMAN J, SHAFFER D, GOODMAN S, NARROW W, WEISSMAN M, KANDEL D, JENSEN P, RICHTERS J, REGIER D. The NIMH Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study: Background and Methodology. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 855-864. PMID: 8768345, DOI: 10.1097/00004583-199607000-00011.Peer-Reviewed Original ResearchConceptsPopulation-based sampleService utilizationResponse rateAdolescent Mental Disorders (MECA) StudyMental disordersMental health service useNIMH Diagnostic Interview ScheduleChildren Version 2.3Epidemiology of ChildHealth service useBetter response rateDiagnostic Interview ScheduleMental Disorders StudyLarge-scale epidemiological surveysYears of ageProbability household sampleAdult caretakersNIMH MethodsRisk factorsFunctional impairmentLay interviewersComputer-assisted versionService useEpidemiological surveyDisorders StudyCriterion Validity of the NIMH Diagnostic Interview Schedule for Children Version 2.3 (DISC-2.3)
SCHWAB-STONE M, SHAFFER D, DULCAN M, JENSEN P, FISHER P, BIRD H, GOODMAN S, LAHEY B, LICHTMAN J, CANINO G, RUBIO-STIPEC M, RAE D. Criterion Validity of the NIMH Diagnostic Interview Schedule for Children Version 2.3 (DISC-2.3). Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 878-888. PMID: 8768347, DOI: 10.1097/00004583-199607000-00013.Peer-Reviewed Original ResearchConceptsNIMH Diagnostic Interview ScheduleChildren Version 2.3Diagnostic Interview ScheduleAdolescent Mental Disorders (MECA) StudyClinician symptom ratingsEpidemiology of ChildPresence of symptomsMental Disorders StudyNumber of diagnosesCriterion validityInterview scheduleSpecific diagnostic areasNIMH MethodsParent-youth pairsDiagnostic areasDiagnostic agreementSymptom ratingsSymptom reportsPrimary caregiversDiagnosisComparison of discScreen negativesDisorders StudyGood validityValidity study