Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy
Haka AS, Sue E, Zhang C, Bhardwaj P, Sterling J, Carpenter C, Leonard M, Manzoor M, Walker J, Aleman JO, Gareau D, Holt PR, Breslow JL, Zhou XK, Giri D, Morrow M, Iyengar N, Barman I, Hudis CA, Dannenberg AJ. Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy. Analytical Chemistry 2016, 88: 2140-2148. PMID: 26752499, PMCID: PMC4799653, DOI: 10.1021/acs.analchem.5b03696.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, WhiteAnimalsDisease Models, AnimalFemaleHumansInflammationMaleMiceMice, Inbred C57BLObesitySpectrum Analysis, RamanConceptsOverweight/obese individualsCurrent histopathological techniquesType 2 diabetesObesity-related diseasesWhite adipose tissueCardiometabolic complicationsInflammatory changesNormal weightObese individualsTissue inflammationOverweight individualsCardiovascular diseaseAdipose tissueHistopathological techniquesDisease riskTissue excisionDiseaseNoninvasive detectionLabel-free Raman spectroscopyObjective risk assessmentSubstantial numberHuman tissuesRiskTissueNoninvasive Raman spectroscopy