2009
Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects
Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects. PLOS ONE 2009, 4: e4221. PMID: 19156209, PMCID: PMC2626248, DOI: 10.1371/journal.pone.0004221.Peer-Reviewed Original ResearchConceptsCardiovascular developmentMass spectrometry-based proteomicsSpectrometry-based proteomicsNormal cardiovascular developmentAdhesion/migrationHuman CHDsProteomic datasetsHeart developmentProtein clustersMurine embryosProtein pathwayMolecular pathwaysFunctional roleProteinEmbryonic survivalYolk sacProtein levelsIdentifies biomarkersCardiovascular defectsWestern blottingPathwayNovel avenuesEmbryosComplete understandingProtein biomarkers
1998
The role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection
Hsu C, Meaddough E, Aversa K, Copel J. The role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection. American Journal Of Obstetrics And Gynecology 1998, 178: 428-432. PMID: 9539502, DOI: 10.1016/s0002-9378(98)70414-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCarboxylic Ester HydrolasesChemokine CXCL1ChemokinesChemokines, CXCChemotactic FactorsCreatinineFemaleGlucoseGrowth SubstancesHumansInfectionsIntercellular Signaling Peptides and ProteinsInterleukin-8L-SelectinLeukocyte CountPregnancyStatistics, NonparametricConceptsSoluble L-selectinIntraamniotic infectionAmniotic fluid levelsInterleukin-8L-selectinPregnant womenRank correlation testFluid levelsAmniotic fluid creatinine levelsPositive amniotic fluid cultureAmniotic fluid glucose concentrationAmniotic fluid leukocytesRupture of membranesAmniotic fluid leukocyte countsMann-Whitney UtestAmniotic fluid testsPotent leukocyte chemoattractantLeukocyte esterase activityAmniotic fluid cultureEnzyme-linked immunoassayPreterm contractionsCreatinine levelsSpearman rank correlation testLeukocyte countFluid culture