Knockout of the Rodent Malaria Parasite Chitinase PbCHT1 Reduces Infectivity to Mosquitoes
Dessens J, Mendoza J, Claudianos C, Vinetz J, Khater E, Hassard S, Ranawaka G, Sinden R. Knockout of the Rodent Malaria Parasite Chitinase PbCHT1 Reduces Infectivity to Mosquitoes. Infection And Immunity 2001, 69: 4041-4047. PMID: 11349074, PMCID: PMC98467, DOI: 10.1128/iai.69.6.4041-4047.2001.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAnimals, Genetically ModifiedAnophelesChitinasesGene DeletionHost-Parasite InteractionsMalariaMolecular Sequence DataPlasmodium bergheiSequence Analysis, DNAConceptsPeritrophic matrixChitinase geneChitinase activityHuman malaria parasite Plasmodium falciparumMalaria parasite Plasmodium falciparumPlasmodium-mosquito interactionsAvian malaria parasite Plasmodium gallinaceumAvian malaria transmissionParasite Plasmodium falciparumMalaria parasite Plasmodium gallinaceumChitin-containing structuresNull mutantsRodent malaria parasiteInfected blood mealMalaria ookinetesTransmission-blocking drugsAnopheles stephensi mosquitoesMidgut invasionStructural orthologsMosquito midgutOokinete invasionPM disruptionMidgut epitheliumTargeted disruptionMalaria transmissionPlasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix
Langer R, Vinetz J. Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix. Trends In Parasitology 2001, 17: 269-272. PMID: 11378031, DOI: 10.1016/s1471-4922(01)01918-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedChitinasesCulicidaeHost-Parasite InteractionsModels, MolecularPlasmodiumConceptsMosquito midgutMalaria transmission-blocking strategiesParasite-mosquito interactionsTransmission-blocking strategiesTransmission-blocking drugsGlobal malaria controlPeritrophic matrixMalaria transmissionTransgenic mosquitoesMalaria controlCandidate targetsChitinasesMidgutChitinaseCrucial roleVaccine