Ecology and larval population dynamics of the primary malaria vector Nyssorhynchus darlingi in a high transmission setting dominated by fish farming in western Amazonian Brazil
Rufalco-Moutinho P, Kadri S, Alonso D, Moreno M, Carrasco-Escobar G, Prussing C, Gamboa D, Vinetz JM, Sallum M, Conn JE, Ribolla P. Ecology and larval population dynamics of the primary malaria vector Nyssorhynchus darlingi in a high transmission setting dominated by fish farming in western Amazonian Brazil. PLOS ONE 2021, 16: e0246215. PMID: 33831004, PMCID: PMC8031405, DOI: 10.1371/journal.pone.0246215.Peer-Reviewed Original ResearchConceptsHigh transmission settingsHigh human densityHuman biting rateMalaria transmission hotspotsWestern Amazonian BrazilLocal malaria burdenLarval population dynamicsAquatic vegetationLandscape typesHuman densitySame sampling periodMalaria burdenRural landscapesTransmission settingsDarlingi larvaeWestern AcrePopulation maintenanceUrban landscapeAdult samplingMain malaria vectorBreeding sitesLandscape profileDry seasonMalaria vector speciesPopulation dynamicsPvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon
Villasis E, Garro K, Rosas-Aguirre A, Rodriguez P, Rosado J, Gave A, Guzman-Guzman M, Manrique P, White M, Speybroeck N, Vinetz JM, Torres K, Gamboa D. PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon. Pathogens 2021, 10: 282. PMID: 33801386, PMCID: PMC7999794, DOI: 10.3390/pathogens10030282.Peer-Reviewed Original ResearchSerological responsePopulation-based cross-sectional surveyRecent malaria exposureMerozoite surface protein 8Non-exposed individualsCross-sectional surveyMalaria control effortsTime of surveyPV exposureMalaria exposureIgG antibodiesTransmission settingsPV infectionGood biomarkerRecent exposurePast monthIgGPlasma samplesProtein 8Second evaluationExposureFirst evaluationIndividualsLuminexCohortHeterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
Rosado J, White MT, Longley RJ, Lacerda M, Monteiro W, Brewster J, Sattabongkot J, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Gamboa D, Mueller I. Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. PLOS Neglected Tropical Diseases 2021, 15: e0009165. PMID: 33591976, PMCID: PMC7909627, DOI: 10.1371/journal.pntd.0009165.Peer-Reviewed Original ResearchConceptsSerological exposure markersBlood-stage infectionLow transmission settingsP. vivax infectionPlasmodium vivax infectionHigh transmission settingsVivax infectionTransmission settingsAntibody titersAntibody responseExposure markersDifferent transmission intensitiesIgG responsesSerological markersPrevious infectionReceiver Operating Characteristic (ROC) analysisEndemic settingsMalaria eliminationPeruvian cohortOperating characteristics analysisP. vivaxMalaria controlRecent exposureInfectionEpidemiological context