2020
79 Leptospirosis
Vinetz J, Watt G. 79 Leptospirosis. 2020, 636-640. DOI: 10.1016/b978-0-323-55512-8.00079-x.Peer-Reviewed Original ResearchSevere leptospirosisAcute kidney injuryEndothelial cell dysfunctionKey pathologic featuresThird-generation cephalosporinsMarked functional impairmentHigh mortality ratePathogenesis of leptospirosisMost disease transmissionRefractory shockKidney injuryOral doxycyclineParenteral penicillinPulmonary hemorrhageSubstantial morbidityPathologic featuresHistopathologic changesFunctional impairmentAvailable vaccinesCell dysfunctionDiagnostic confirmationRisk populationsMilder casesMortality rateLeptospirosis
2005
Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden
Segura ER, Ganoza CA, Campos K, Ricaldi JN, Torres S, Silva H, Céspedes MJ, Matthias MA, Swancutt MA, Liñán R, Gotuzzo E, Guerra H, Gilman RH, Vinetz JM, Consortium P. Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden. Clinical Infectious Diseases 2005, 40: 343-351. PMID: 15668855, PMCID: PMC2366057, DOI: 10.1086/427110.Peer-Reviewed Original ResearchConceptsPulmonary involvementFebrile patientsAcute respiratory distress syndromeMost fatal casesSevere pulmonary manifestationsRespiratory distress syndromePopulation-based studyEvidence of exposureDiagnosis of leptospirosisRegions of endemicityPulmonary complicationsMultiorgan failurePulmonary manifestationsPresumptive treatmentDistress syndromePulmonary hemorrhageSerologic testingIgM antibodiesClinical spectrumPulmonary casesFatal casesQuantitative real-time PCRReal-time PCRAntileptospiral antibodiesLeptospiral burden
2001
Leptospirosis
Vinetz J. Leptospirosis. Current Opinion In Infectious Diseases 2001, 14: 527-538. PMID: 11964872, DOI: 10.1097/00001432-200110000-00005.Peer-Reviewed Original ResearchConceptsPopulation-based studyViral hemorrhagic feverImportant zoonotic diseasePulmonary hemorrhageFebrile syndromeLethal complicationTyphoid vaccineClinical expressionLeptospiral geneHemorrhagic feverLeptospirosis vaccineInfectious diseasesLeptospirosisLeptospira spDiseaseVaccineZoonotic diseaseMammalian reservoir hostsLeptospiral strainsRecent reportsLeptospira genomeReservoir hostsPoor correlationComplicationsHemorrhage