2024
Transmission-reducing and -enhancing monoclonal antibodies against Plasmodium vivax gamete surface protein Pvs48/45
Bansal G, da Silva Araujo M, Cao Y, Shaffer E, Araujo J, Medeiros J, Hayashi C, Vinetz J, Kumar N. Transmission-reducing and -enhancing monoclonal antibodies against Plasmodium vivax gamete surface protein Pvs48/45. Infection And Immunity 2024, 92: e00374-23. PMID: 38289124, PMCID: PMC10929423, DOI: 10.1128/iai.00374-23.Peer-Reviewed Original ResearchDirect membrane feeding assaysTransmission-blocking vaccinesTransmission-blocking vaccine developmentMalaria transmission-blocking vaccineBlocked oocyst developmentInfectivity of gametocytesMale gamete fertilityMonoclonal antibodiesMembrane feeding assaysTransmission-blocking activityPvs48/45Activity of antibodiesNon-overlapping epitopesOocyst developmentPotential vaccine candidatesIndividual MAbsVaccine candidatesEffective immunogensChallenge modelMAbAntibodiesGametocytesEpitopesRecombinant fragmentsEnhanced activity
2018
Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study
White SE, Harvey SA, Meza G, Llanos A, Guzman M, Gamboa D, Vinetz JM. Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study. Malaria Journal 2018, 17: 179. PMID: 29703192, PMCID: PMC5921293, DOI: 10.1186/s12936-018-2328-z.Peer-Reviewed Original ResearchConceptsTransmission-blocking malaria vaccineTransmission-blocking vaccinesMalaria vaccineMalaria transmission-blocking vaccineMalaria hypoendemic regionMalaria vaccine strategyProspective cohort studyMalaria-endemic communitiesMalaria-endemic regionsPre-validated questionnaireCohort studyVaccine strategiesMalaria infectionMethodsThe studyVaccineMalaria controlMalaria researchMultiple injectionsOne-thirdIndustrialized worldInjectionAcceptabilityCohortInfectionStudy