Featured Publications
Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil
Torres K, Ferreira MU, Castro MC, Escalante AA, Conn JE, Villasis E, da Silva Araujo M, Almeida G, Rodrigues PT, Corder RM, Fernandes ARJ, Calil PR, Ladeia WA, Garcia-Castillo SS, Gomez J, do Valle Antonelli LR, Gazzinelli RT, Golenbock DT, Llanos-Cuentas A, Gamboa D, Vinetz JM. Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil. American Journal Of Tropical Medicine And Hygiene 2022, 107: 168-181. PMID: 36228921, PMCID: PMC9662219, DOI: 10.4269/ajtmh.22-0127.Peer-Reviewed Original ResearchConceptsImmune responseMalaria epidemiologyMalaria controlImportant public health priorityHuman immune responsePublic health priorityWestern Brazilian Amazon regionHealth priorityHuman reservoirSociodemographic featuresMalaria researchEpidemiologyMultidisciplinary approachRapid reemergenceVector biologyElimination strategyResearch NetworkMalaria vectorsInternational CentreFurther researchBrazilian Amazon regionSouth AmericaMalariaImmunologyResponse
2024
Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon
Cabrera-Sosa L, Nolasco O, Kattenberg J, Fernandez-Miñope C, Valdivia H, Barazorda K, Arévalo de los Rios S, Rodriguez-Ferrucci H, Vinetz J, Rosanas-Urgell A, Van geertruyden J, Gamboa D, Delgado-Ratto C. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon. Scientific Reports 2024, 14: 16291. PMID: 39009685, PMCID: PMC11250820, DOI: 10.1038/s41598-024-66925-x.Peer-Reviewed Original ResearchConceptsPassive case detectionPf parasitesPersistent malaria transmissionPfhrp2/3 gene deletionsDeep sequencing assaySulfadoxine-pyrimethamineMalaria casesMalaria eliminationPlasmodium vivaxMalaria parasitesMalaria transmissionP. falciparumResistance mutationsImported infectionsMalariaPopulation genetic indicesSequencing assayCase detectionGene deletionPV populationResistance markersGenetic diversityPeruvian AmazonGenomic surveillanceGenetic indicesCase Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi
Dos Santos N, da Silva Bastos A, Araújo J, Pontual J, Medeiros J, Vinetz J, da Silva Araujo M. Case Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi. American Journal Of Tropical Medicine And Hygiene 2024, 110: 444-447. PMID: 38350139, PMCID: PMC10919193, DOI: 10.4269/ajtmh.23-0349.Peer-Reviewed Original ResearchResponses to P. vivaxPlasmodium falciparum parasitesPrimary malaria vectorPlasmodium vivaxVector Anopheles darlingiFalciparum parasitesMalaria parasitesMalaria vector Anopheles darlingiPlasmodium parasitesSalivary glandsMalaria vectorsPlasmodiumAnopheline mosquitoesAnopheles darlingiMalariaDarlingiVivaxSalivaryGlandA prospective cohort study linking migration, climate, and malaria risk in the Peruvian Amazon – CORRIGENDUM
Gunderson A, Recalde-Coronel C, Zaitchik B, Yori P, Pinedo S, Olortegui M, Kosek M, Vinetz J, Pan W. A prospective cohort study linking migration, climate, and malaria risk in the Peruvian Amazon – CORRIGENDUM. Epidemiology And Infection 2024, 152: e5. PMID: 38214060, PMCID: PMC10789972, DOI: 10.1017/s0950268824000025.Peer-Reviewed Original Research
2023
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
Andrade A, Santos N, Bastos A, Pontual J, Araújo J, Silva A, Martinez L, Lima A, Aguiar A, Teles C, Medeiros J, Pereira D, Vinetz J, Gazzinelli R, Araújo M. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLOS Neglected Tropical Diseases 2023, 17: e0011425. PMID: 37327209, PMCID: PMC10310017, DOI: 10.1371/journal.pntd.0011425.Peer-Reviewed Original ResearchConceptsDensity of gametocytesTransmission-blocking efficacyPlasmodium vivax malariaTransmission-blocking activityImportant infectious diseasesOne-doseVivax malariaP. vivaxMosquito infectionPlasmodium vivaxTreatment groupsPatient's bloodGametocyte productionMalaria transmissionInfectious diseasesGenus PlasmodiumMalariaTreatmentChloroquinePrimaquineVivaxBloodDirect membraneBiological characteristicsMosquitoes
2022
Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru
Watts DM, Russell KL, Wooster MT, Sharp TW, Morrison AC, Kochel TJ, Bautista CT, Block K, Guevara C, Aguilar P, Palermo PM, Calampa C, Porter KR, Hayes CG, Weaver SC, de Rosa AT, Vinetz JM, Shope RE, Gotuzzo E, Guzman H, Tesh RB. Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru. American Journal Of Tropical Medicine And Hygiene 2022, 107: 1114-1128. PMID: 36162442, PMCID: PMC9709010, DOI: 10.4269/ajtmh.22-0259.Peer-Reviewed Original ResearchConceptsFebrile illnessAcute undifferentiated febrile illnessUndifferentiated febrile illnessFebrile patientsAcute leptospirosisFebrile casesAsymptomatic infectionIgG antibodiesHealth burdenHealth clinicsClinical dataBlood samplesMicroscopic agglutinationDengue virusPatientsEncephalitis virusBlood smearsHuman morbidityLeptospira sppMalariaFurther studiesArbovirusesHealth impactsBaseline knowledgeEtiology
2021
Transmission-Blocking Preventive Measures for Infectious Diseases: Altruism, Solidarity, and the Common Good
Garber L, Vinetz JM. Transmission-Blocking Preventive Measures for Infectious Diseases: Altruism, Solidarity, and the Common Good. American Journal Of Tropical Medicine And Hygiene 2021, 104: 1609-1610. PMID: 33705347, PMCID: PMC8103472, DOI: 10.4269/ajtmh.20-1005.Peer-Reviewed Original Research
2006
314 EXPERIMENTAL INFECTION OF ANOPHELES DARLINGI MOSQUITOES BY PLASMODIUM VIVAX FROM NATURALLY INFECTED PATIENTS IN THE PERUVIAN AMAZON.
Bharti A, Chuquiyauri R, Segura E, Lopez V, Stancil J, Llanos A, Vinetz J. 314 EXPERIMENTAL INFECTION OF ANOPHELES DARLINGI MOSQUITOES BY PLASMODIUM VIVAX FROM NATURALLY INFECTED PATIENTS IN THE PERUVIAN AMAZON. Journal Of Investigative Medicine 2006, 54: s134. DOI: 10.2310/6650.2005.x0004.313.Peer-Reviewed Original ResearchP. vivaxPlasmodium vivaxP. vivax infectionIncidence of malariaLife-threatening diseaseTransmission of infectionOocyst loadMembrane feeding techniqueSymptomatic patientsArtificial membrane feeding techniqueVivax malariaVivax infectionInterventional methodsPatientsInfected mosquitoesExperimental infectionDarlingi mosquitoesMosquito midgutVivaxAlternative interventionsInfectionMicroscopic examinationCurrent control measuresInfected midgutsMalaria
2001
Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia
Zhang Y, Telleria L, Vinetz J, Yawn D, Rossmann S, Indrikovs A. Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia. Journal Of Clinical Apheresis 2001, 16: 15-18. PMID: 11309825, DOI: 10.1002/jca.1002.Peer-Reviewed Original ResearchConceptsRed blood cell exchangeCell exchangeAnti-malarial chemotherapyWhole blood exchangeEnd-organ dysfunctionLife-threatening complicationsPlasmodium falciparum infectionRed cell exchangeCirculation of patientsDegree of parasitemiaComplicated malariaCerebral malariaRenal dysfunctionFalciparum infectionHigher parasite loadsBlood exchangePatientsP. falciparumFull recoveryPlasmodium falciparumMalariaParasite loadHyperparasitemiaChemotherapyParasitemia