2021
Evolutionary Insights into the Microneme-Secreted, Chitinase-Containing High-Molecular-Weight Protein Complexes Involved in Plasmodium Invasion of the Mosquito Midgut
Kaur H, Pacheco MA, Garber L, Escalante AA, Vinetz JM. Evolutionary Insights into the Microneme-Secreted, Chitinase-Containing High-Molecular-Weight Protein Complexes Involved in Plasmodium Invasion of the Mosquito Midgut. Infection And Immunity 2021, 90: e00314-21. PMID: 34606368, PMCID: PMC8788677, DOI: 10.1128/iai.00314-21.Peer-Reviewed Original ResearchConceptsPeritrophic matrixMosquito midgutNew genomic insightsWeight protein complexesHigh-resolution structural modelingDomain-related proteinEvolutionary insightsInvasion machineryGenomic insightsMicronemal proteinsProtein complexesThree-dimensional structureMosquito interactionsGenomic dataPlasmodium invasionProteolytic milieuMidgut epitheliumWeight complexesAdhesive proteinsOokinetesGeneral mechanismProteinChitinasesMidgutChitinase
2001
Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix
Langer R, Vinetz J. Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix. Trends In Parasitology 2001, 17: 269-272. PMID: 11378031, DOI: 10.1016/s1471-4922(01)01918-3.Peer-Reviewed Original ResearchConceptsMosquito midgutMalaria transmission-blocking strategiesParasite-mosquito interactionsTransmission-blocking strategiesTransmission-blocking drugsGlobal malaria controlPeritrophic matrixMalaria transmissionTransgenic mosquitoesMalaria controlCandidate targetsChitinasesMidgutChitinaseCrucial roleVaccine
1999
Chitinases of human parasites and their implications as antiparasitic targets.
Shahabuddin M, Vinetz J. Chitinases of human parasites and their implications as antiparasitic targets. EXS 1999, 87: 223-34. PMID: 10906963, DOI: 10.1007/978-3-0348-8757-1_16.Peer-Reviewed Original ResearchConceptsDevelopmental stage-specific mannerStage-specific mannerAmino acid sequenceChitin-containing structuresPathogenic parasitesAnimal diseasesAntiparasitic targetsChitinase geneInsect vectorsAcid sequenceSuccessful infectionChitinasesHuman parasitesParasitesNumber of humanGenesLife cycleChitinAnimal bodyPathogensRecent studiesHarsh conditionsVertebratesChitinaseOrganisms