2017
Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility
Santos-Sacchi J, Navaratnam D, Raphael R, Oliver D. Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility. Springer Handbook Of Auditory Research 2017, 62: 113-145. DOI: 10.1007/978-3-319-52073-5_5.Peer-Reviewed Original ResearchOuter hair cellsMammalian inner earOuter Hair Cell ElectromotilityHair cell electromotilitySLC26 familyMolecular mechanismsMembrane lipidsConformational changesMechanical feedback mechanismMolecular motorsTension sensitivityPrestinHair cellsVoltage-sensor charge movementAnion transportersReceptor potentialProteinMolecular conformational changesInner earStructural determinationIntracellular chlorideCharge movementTraffickingFeedback mechanismMechanism
2008
Anion Control of Voltage Sensing by the Motor Protein Prestin in Outer Hair Cells
Rybalchenko V, Santos-Sacchi J. Anion Control of Voltage Sensing by the Motor Protein Prestin in Outer Hair Cells. Biophysical Journal 2008, 95: 4439-4447. PMID: 18658219, PMCID: PMC2567960, DOI: 10.1529/biophysj.108.134197.Peer-Reviewed Original ResearchConceptsOuter hair cellsHair cellsCochlear amplificationSLC26 anion transporter familyMotor protein prestinMammalian cochlear amplificationVoltage-sensor charge movementAuditory responsivenessCorti's organAnion transporter familyTransporter familyProtein prestinMolecular motorsCharge movementPrestinOrgansCellsComplicated roleVoltage sensingCochlear Mechanics: No Shout but a Twist in the Absence of Prestin
Santos-Sacchi J. Cochlear Mechanics: No Shout but a Twist in the Absence of Prestin. Current Biology 2008, 18: r304-r306. PMID: 18397741, DOI: 10.1016/j.cub.2008.02.019.Peer-Reviewed Original Research
2007
Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse
Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse. The Journal Of Membrane Biology 2007, 215: 49-56. PMID: 17415610, PMCID: PMC4154540, DOI: 10.1007/s00232-007-9004-5.Peer-Reviewed Original ResearchConceptsLateral membranesOuter hair cellsMouse outer hair cellsMotor protein activitySteady-state levelsKnockout experimentsProtein activityDevelopmental expressionMembrane tensionGenetic modificationConformational fluctuationsCellular mechanismsMotor moleculesMolecular motorsOnset of hearingMorphological estimatesProtein densityEarly maturationQuantitative polymerase chain reactionHair cellsVpkCmDevelopmental dataCochlear amplificationMaturationFull maturation
2002
Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor
Santos-Sacchi J, Navarrete E. Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor. Pflügers Archiv - European Journal Of Physiology 2002, 444: 99-106. PMID: 11976921, DOI: 10.1007/s00424-002-0804-2.Peer-Reviewed Original ResearchConceptsMembrane motorHEK cellsOuter hair cellsArea motor modelLateral membrane areaLateral plasma membranePlasma membraneProtein prestinConstant membrane thicknessConformational changesCharge movementMembrane capacitanceMolecular motorsPrestinMembrane surface areaVoltage sensorDeiters' cellsHair cellsCellsExtreme hyperpolarizationMembrane voltageVoltage-dependent changesMembrane area
2001
Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane
Takahashi S, Santos-Sacchi J. Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane. Pflügers Archiv - European Journal Of Physiology 2001, 441: 506-513. PMID: 11212214, DOI: 10.1007/s004240000455.Peer-Reviewed Original ResearchConceptsCell plasma membranePlasma membraneLateral membranesOuter hair cell plasma membraneVoltage-dependent motilityMammalian cochlear amplifierOuter hair cell electromotilityMembrane microdomainsGating currentsHair cell electromotilityTurgor pressureOHC motorMolecular motorsElectromotile responseMembraneMotilityCytoskeletonCharge movementBell-shaped distributionMicrodomainsElectromotilityNon-uniform mappingPronase treatmentCochlear amplifierPronase