2001
Furosemide alters nonlinear capacitance in isolated outer hair cells
Santos-Sacchi J, Wu M, Kakehata S. Furosemide alters nonlinear capacitance in isolated outer hair cells. Hearing Research 2001, 159: 69-73. PMID: 11520635, DOI: 10.1016/s0378-5955(01)00321-5.Peer-Reviewed Original ResearchConceptsOuter hair cellsWhole-cell patch-clamp techniqueHair cellsNormal cochlear functionIsolated outer hair cellsPatch-clamp techniqueOrgan of CortiLoop diureticsSensory dysfunctionHearing resultsCochlear functionEndolymphatic potentialFurosemideDirect effectHill coefficientPositive levelCellsDiureticsDysfunctionPresent results
1996
Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge
Kakehata S, Santos-Sacchi J. Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge. Journal Of Neuroscience 1996, 16: 4881-4889. PMID: 8756420, PMCID: PMC6579298, DOI: 10.1523/jneurosci.16-16-04881.1996.Peer-Reviewed Original ResearchConceptsOuter hair cellsEffects of salicylateConcentration-response curvesGuinea pig outer hair cellsOHC motilityAuditory frequency selectivityForm of salicylateHalf-maximal concentrationReversible tinnitusHearing lossDepolarized levelsHair cell motilityComparable groupsHair cellsOuter Hair Cell MotilityInner aspectOuter aspectSubsurface cisternaeTrypsin treatmentMotilityPressure changesHill coefficientSalicylatePresent experimentsVoltage-induced movement