2023
Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
Wallach J, Deng Y, Polley E, Dhruva S, Herrin J, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Jeffery M, Lyon T, Ross J, McCoy R. Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials. Clinical Trials 2023, 20: 689-698. PMID: 37589143, PMCID: PMC10843567, DOI: 10.1177/17407745231193137.Peer-Reviewed Original ResearchMeSH KeywordsHumansLongitudinal StudiesMyocardial InfarctionPandemicsRandomized Controlled Trials as TopicResearch DesignConceptsBaseline participant characteristicsParticipant characteristicsPrimary endpointSecondary endpointsTrial publicationsMajor adverse cardiovascular eventsPropensity score-matched participantsFirst major adverse cardiovascular eventAdverse cardiovascular eventsBaseline patient characteristicsNonfatal myocardial infarctionOptumLabs Data WarehouseElectronic health record dataRepresentative patient populationHealth record dataCardiovascular eventsClinical characteristicsPatient characteristicsPatient populationMyocardial infarctionExclusion criteriaDrug effectivenessTrialsRecord dataEndpoint
2021
Cardiovascular outcomes and rates of fractures and falls among patients with brand-name versus generic L-thyroxine use
Brito JP, Ross JS, Deng Y, Sangaralingham L, Graham DJ, Qiang Y, Wang Z, Yao X, Zhao L, Smallridge RC, Bernet V, Shah ND, Lipska KJ. Cardiovascular outcomes and rates of fractures and falls among patients with brand-name versus generic L-thyroxine use. Endocrine 2021, 74: 592-602. PMID: 34089480, PMCID: PMC9210353, DOI: 10.1007/s12020-021-02779-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedDrugs, GenericFemaleHumansLongitudinal StudiesRetrospective StudiesThyroid HormonesThyroxineConceptsCongestive heart failureRate of fracturesCardiovascular outcomesL-thyroxineRate of fallHeart failureHip fractureAtrial fibrillationMyocardial infarctionNational administrative claims databasePropensity-matched patientsAdministrative claims databaseRate of hospitalizationMIU/L.Main outcome measuresSignificant differencesDose subgroupsHospitalization ratesClaims databaseThyroid cancerInpatient settingBaseline thyroidHormone levelsOutcome measuresPatientsEffects of forced disruption in Medicaid managed care on children with asthma
Piwnica‐Worms K, Staiger B, Ross JS, Rosenthal MS, Ndumele CD. Effects of forced disruption in Medicaid managed care on children with asthma. Health Services Research 2021, 56: 668-676. PMID: 33624290, PMCID: PMC8313960, DOI: 10.1111/1475-6773.13643.Peer-Reviewed Original ResearchConceptsPrimary care providersPersistent asthmaCare plansOutpatient visitsCare utilizationCare administrative claims dataEmergency department utilizationHealth care utilizationAdministrative claims dataIndicators of asthmaProportion of childrenPatients outpatientHealth utilizationAdministrative claimsAsthmaCare providersClaims dataNumber of childrenConsistent associationMedicaidVisitsChildrenOutpatientsPercentage point decreaseEnrollment dataPhysician variation in the de‐adoption of ineffective statin and fibrate therapy
Everhart A, Desai NR, Dowd B, Herrin J, Higuera L, Jeffery MM, Jena AB, Ross JS, Shah ND, Smith LB, Karaca‐Mandic P. Physician variation in the de‐adoption of ineffective statin and fibrate therapy. Health Services Research 2021, 56: 919-931. PMID: 33569804, PMCID: PMC8522575, DOI: 10.1111/1475-6773.13630.Peer-Reviewed Original ResearchMeSH KeywordsAgedDiabetes Mellitus, Type 2Drug Therapy, CombinationDrug UtilizationFemaleFibric AcidsGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsHypolipidemic AgentsLongitudinal StudiesMaleMedicare Part CMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Risk FactorsUnited StatesConceptsMedicare Advantage patientsType 2 diabetic patientsACCORD lipid trialFibrate useAdvantage patientsCommercial patientsPhysician characteristicsLIPID trialFibrate therapyDiabetic patientsPhysician variationDiabetes careType 2 diabetes diagnosisContinuous insurance enrollmentPatient diabetes carePhysician random effectsGlucose-lowering drugsElectronic health record dataHealth record dataReal-world data assetConcurrent statinCardiovascular eventsStatin usersClinical evidenceManagement visits
2020
Comparative Effectiveness of Generic vs Brand-Name Levothyroxine in Achieving Normal Thyrotropin Levels
Brito JP, Ross JS, Sangaralingham L, Dutcher SK, Graham DJ, Wang Z, Wu Y, Yao X, Smallridge RC, Bernet V, Shah ND, Lipska KJ. Comparative Effectiveness of Generic vs Brand-Name Levothyroxine in Achieving Normal Thyrotropin Levels. JAMA Network Open 2020, 3: e2017645. PMID: 32997127, PMCID: PMC7527873, DOI: 10.1001/jamanetworkopen.2020.17645.Peer-Reviewed Original ResearchConceptsNormal thyrotropin levelsPropensity score-matched patientsThyrotropin levelsLevothyroxine prescriptionsThyrotropin valuesProportion of patientsAdministrative claims databaseMonths of initiationMIU/LMild thyroid dysfunctionLongitudinal cohort studyMedicare Advantage enrolleesNormal thyrotropin valuesEligible patientsInitial therapyLevothyroxine formulationsCohort studyThyroid dysfunctionClaims databaseGeneric levothyroxineLevothyroxineMAIN OUTCOMENormal rangePatientsNormal vs
2016
Association Between Hospital Penalty Status Under the Hospital Readmission Reduction Program and Readmission Rates for Target and Nontarget Conditions
Desai NR, Ross JS, Kwon JY, Herrin J, Dharmarajan K, Bernheim SM, Krumholz HM, Horwitz LI. Association Between Hospital Penalty Status Under the Hospital Readmission Reduction Program and Readmission Rates for Target and Nontarget Conditions. JAMA 2016, 316: 2647-2656. PMID: 28027367, PMCID: PMC5599851, DOI: 10.1001/jama.2016.18533.Peer-Reviewed Original ResearchConceptsHospital Readmissions Reduction ProgramAcute myocardial infarctionReadmission ratesReadmissions Reduction ProgramHeart failurePenalty statusNontarget conditionsMedicare feeMean readmission rateThirty-day riskRetrospective cohort studyUnplanned readmission rateReduction programsHRRP announcementHRRP implementationPenalized hospitalsCohort studyService patientsMyocardial infarctionMAIN OUTCOMEExcess readmissionsMedicare beneficiariesService beneficiariesHospitalPatients
2011
Recent trends in chronic disease, impairment and disability among older adults in the United States
Hung WW, Ross JS, Boockvar KS, Siu AL. Recent trends in chronic disease, impairment and disability among older adults in the United States. BMC Geriatrics 2011, 11: 47. PMID: 21851629, PMCID: PMC3170191, DOI: 10.1186/1471-2318-11-47.Peer-Reviewed Original ResearchConceptsPrevalence of impairmentChronic diseasesOlder adultsDaily livingChronic lung diseaseMore chronic diseasesImpairment of cognitionPrevalence of disabilityOlder U.S. adultsProportion of respondentsIADL disabilityUrinary incontinenceLung diseaseHeart diseasePrevalence trendsInstrumental activitiesU.S. adultsDiseasePrevalenceImpairmentAdultsDisabilityMore diseasesRetirement StudyUnited States
2010
A Random Effects Multinomial Logit Analysis of Using Medicare and VA Healthcare Among Veterans With Dementia
Zhu CW, Livote EE, Ross JS, Penrod JD. A Random Effects Multinomial Logit Analysis of Using Medicare and VA Healthcare Among Veterans With Dementia. Home Health Care Services Quarterly 2010, 29: 91-104. PMID: 20635273, PMCID: PMC3233994, DOI: 10.1080/01621424.2010.493771.Peer-Reviewed Original ResearchConceptsMore comorbiditiesFunctional limitationsCaregiver characteristicsNursing homesNational Longitudinal Caregiver StudyPrivate insuranceMedicare useEffect of patientVA Medical CenterMore functional limitationsHigh-quality careVascular dementiaCaregiver StudyMedical CenterVA healthcareMale veteransDual usersAlzheimer's diseaseQuality careOlder ageFormal diagnosisGood healthDementiaUse groupMedicare
2009
Use of Medicare and Department of Veterans Affairs Health Care by Veterans with Dementia: A Longitudinal Analysis
Zhu CW, Penrod JD, Ross JS, Dellenbaugh C, Sano M. Use of Medicare and Department of Veterans Affairs Health Care by Veterans with Dementia: A Longitudinal Analysis. Journal Of The American Geriatrics Society 2009, 57: 1908-1914. PMID: 19682132, PMCID: PMC3233990, DOI: 10.1111/j.1532-5415.2009.02405.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedDementiaHumansLongitudinal StudiesMaleMedicareUnited StatesUnited States Department of Veterans AffairsConceptsMedicare useDual usersGreater likelihoodVeterans Affairs (VA) health careUse of MedicareHigh-quality careMultiple comorbiditiesPatient characteristicsVascular dementiaHigh comorbidityMedicare claimsFunctional limitationsMale veteransNursing homesVA servicesAlzheimer's diseaseVeterans AffairsOlder agePrivate insuranceFormal diagnosisDementiaUse groupHealth careCareLess likelihoodCognitive Decline among Patients with Chronic Obstructive Pulmonary Disease
Hung WW, Wisnivesky JP, Siu AL, Ross JS. Cognitive Decline among Patients with Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 2009, 180: 134-137. PMID: 19423714, DOI: 10.1164/rccm.200902-0276oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseSevere chronic obstructive pulmonary diseaseObstructive pulmonary diseaseCognitive declinePulmonary diseaseEffect of COPDHistory of COPDPopulation-based longitudinal cohortOlder adultsSmall case seriesMultivariable mixed linear modelCognitive performanceLower cognitive performanceClinical characteristicsMultivariable adjustmentPrimary outcomeCase seriesClinical historyLongitudinal cohortActivity limitationsCognitive testingAdultsCognition scoresMean scoreStandardized measurements