2021
Misreporting of Results of Research in Psychiatry
Bowcut J, Levi L, Livnah O, Ross JS, Knable M, Davidson M, Davis JM, Weiser M. Misreporting of Results of Research in Psychiatry. Schizophrenia Bulletin 2021, 47: 1254-1260. PMID: 33860793, PMCID: PMC8379531, DOI: 10.1093/schbul/sbab040.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchData Interpretation, StatisticalHumansOutcome Assessment, Health CarePsychiatryPublication BiasRandomized Controlled Trials as TopicResearch Design
2018
Association of Racial and Socioeconomic Disparities With Outcomes Among Patients Hospitalized With Acute Myocardial Infarction, Heart Failure, and Pneumonia
Downing NS, Wang C, Gupta A, Wang Y, Nuti SV, Ross JS, Bernheim SM, Lin Z, Normand ST, Krumholz HM. Association of Racial and Socioeconomic Disparities With Outcomes Among Patients Hospitalized With Acute Myocardial Infarction, Heart Failure, and Pneumonia. JAMA Network Open 2018, 1: e182044. PMID: 30646146, PMCID: PMC6324513, DOI: 10.1001/jamanetworkopen.2018.2044.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlack PeopleCohort StudiesFee-for-Service PlansFemaleHealth Status DisparitiesHeart FailureHospitalizationHospitalsHumansMaleMedicareMiddle AgedMyocardial InfarctionOutcome Assessment, Health CarePneumoniaRacial GroupsRetrospective StudiesSocial ClassUnited StatesWhite PeopleConceptsAcute myocardial infarctionRisk-standardized mortality ratesRisk-standardized readmission ratesReadmission ratesHeart failureMyocardial infarctionMortality rateIntraclass correlation coefficientAnalysis cohortBlack patientsHospital proportionSocioeconomic disparitiesHospital analysisRisk-standardized outcomesRisk-standardized ratesRetrospective cohort studySocioeconomic statusNeighborhood income levelHospital performanceHospital outcomesCohort studyNumber of hospitalsBroader systemic effectsPatient raceMAIN OUTCOMEDefining Multiple Chronic Conditions for Quality Measurement
Drye EE, Altaf FK, Lipska KJ, Spatz ES, Montague JA, Bao H, Parzynski CS, Ross JS, Bernheim SM, Krumholz HM, Lin Z. Defining Multiple Chronic Conditions for Quality Measurement. Medical Care 2018, 56: 193-201. PMID: 29271820, DOI: 10.1097/mlr.0000000000000853.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesFemaleHumansMaleMedicareMiddle AgedMultiple Chronic ConditionsOutcome Assessment, Health CarePatient ReadmissionQuality Indicators, Health CareUnited StatesConceptsMultiple chronic conditionsChronic conditionsMedicare feeService beneficiariesMedicare Chronic Conditions WarehouseMCC cohortBroad cohortChronic Conditions WarehouseRisk-standardized ratesNational quality measuresUnplanned admissionsFinal cohortTotal admissionsAdmission riskAccountable care organizationsAdmission ratesOutcome measuresAdmissionCohortCohort conditionCare organizationsPatientsStakeholder inputNarrow cohortBeneficiaries
2017
Post‐marketing research and its outcome for novel anticancer agents approved by both the FDA and EMA between 2005 and 2010: A cross‐sectional study
Zeitoun J, Baron G, Vivot A, Atal I, Downing NS, Ross JS, Ravaud P. Post‐marketing research and its outcome for novel anticancer agents approved by both the FDA and EMA between 2005 and 2010: A cross‐sectional study. International Journal Of Cancer 2017, 142: 414-423. PMID: 28929484, DOI: 10.1002/ijc.31061.Peer-Reviewed Original ResearchConceptsPost-marketing trialsPrimary outcomeNovel anticancer agentsPost-market researchAnticancer agentsSupplemental indicationsCross-sectional studyPost-marketing researchEuropean Medicines AgencyCross-sectional analysisTypes of cancerPost-market trialClinical endpointsHematologic malignanciesKidney cancerSolid cancersSurrogate endpointsUS FoodDrug AdministrationMedicines AgencyOverall populationCancerTrialsPublication rateOutcomesAge Differences in Hospital Mortality for Acute Myocardial Infarction: Implications for Hospital Profiling.
Dharmarajan K, McNamara RL, Wang Y, Masoudi FA, Ross JS, Spatz EE, Desai NR, de Lemos JA, Fonarow GC, Heidenreich PA, Bhatt DL, Bernheim SM, Slattery LE, Khan YM, Curtis JP. Age Differences in Hospital Mortality for Acute Myocardial Infarction: Implications for Hospital Profiling. Annals Of Internal Medicine 2017, 167: 555-564. PMID: 28973634, PMCID: PMC9359429, DOI: 10.7326/m16-2871.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedHospital MortalityHospitalsHumansMiddle AgedMyocardial InfarctionOutcome Assessment, Health CareRetrospective StudiesUnited StatesYoung AdultConceptsRisk-standardized mortality ratesAcute myocardial infarctionOlder patientsYounger patientsMyocardial infarctionAge groupsHospital risk-standardized mortality ratesRetrospective cohort studyHospital mortality rankingsNational Quality ForumHospital mortalityMedian hospitalHospital outcomesCohort studyACTION RegistryAMI mortalityAmerican CollegeMedicare beneficiariesAMI hospitalizationPatientsMortality rateHospitalQuality ForumHospital ValueHospital profilingHospital-Readmission Risk — Isolating Hospital Effects from Patient Effects
Krumholz HM, Wang K, Lin Z, Dharmarajan K, Horwitz LI, Ross JS, Drye EE, Bernheim SM, Normand ST. Hospital-Readmission Risk — Isolating Hospital Effects from Patient Effects. New England Journal Of Medicine 2017, 377: 1055-1064. PMID: 28902587, PMCID: PMC5671772, DOI: 10.1056/nejmsa1702321.Peer-Reviewed Original ResearchMeSH KeywordsAgedHospitalsHumansOutcome Assessment, Health CarePatient ReadmissionQuality Indicators, Health CareRisk AdjustmentUnited StatesConceptsRisk-standardized readmission ratesReadmission ratesObserved readmission ratesSimilar diagnosesHospital effectsDifferent hospitalsHospital readmission performanceRate of readmissionHospital readmission ratesLower readmission ratesStudy sampleYears of ageSignificant differencesMultiple admissionsReadmission outcomesOnly significant differencePatient effectsSame patientMedicare recipientsPatientsReadmission performanceRisk-standardized hospital readmission ratesHospitalHospital qualityQuartileAssociation of the FDA Amendment Act with trial registration, publication, and outcome reporting
Phillips AT, Desai NR, Krumholz HM, Zou CX, Miller JE, Ross JS. Association of the FDA Amendment Act with trial registration, publication, and outcome reporting. Trials 2017, 18: 333. PMID: 28720112, PMCID: PMC5516301, DOI: 10.1186/s13063-017-2068-3.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseTRIAL REGISTRATIONFDA approvalNew drugsClinical trial registrationFDA Amendments ActDrug Administration Amendments ActAccessible trial registryClinical trial publicationsTrials RegistryResultsBetween 2005Efficacy trialsFDA reviewersTrial publicationsOutcome reportingMedical literatureReviewer interpretationsTrialsReporting of findingsDiseaseFDA documentsDrugsDiabetesFDAAAReviewers
2016
Declining Admission Rates And Thirty-Day Readmission Rates Positively Associated Even Though Patients Grew Sicker Over Time
Dharmarajan K, Qin L, Lin Z, Horwitz LI, Ross JS, Drye EE, Keshawarz A, Altaf F, Normand SL, Krumholz HM, Bernheim SM. Declining Admission Rates And Thirty-Day Readmission Rates Positively Associated Even Though Patients Grew Sicker Over Time. Health Affairs 2016, 35: 1294-1302. PMID: 27385247, DOI: 10.1377/hlthaff.2015.1614.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCenters for Medicare and Medicaid Services, U.S.Chronic DiseaseDatabases, FactualDisease ProgressionFemaleGeriatric AssessmentHospital MortalityHumansIncidenceLength of StayMaleOutcome Assessment, Health CarePatient AdmissionPatient ReadmissionRetrospective StudiesRisk AssessmentSeverity of Illness IndexTime FactorsUnited States
2015
Hospital-Based Acute Care After Total Hip and Knee Arthroplasty: Implications for Quality Measurement
Trimba R, Laughlin RT, Krishnamurthy A, Ross JS, Fox JP. Hospital-Based Acute Care After Total Hip and Knee Arthroplasty: Implications for Quality Measurement. The Journal Of Arthroplasty 2015, 31: 573-578.e2. PMID: 26689614, DOI: 10.1016/j.arth.2015.10.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedArthroplasty, Replacement, HipArthroplasty, Replacement, KneeDatabases, FactualEmergency Service, HospitalFemaleHumansMaleMiddle AgedOutcome Assessment, Health CarePatient DischargePatient ReadmissionQuality Assurance, Health CareQuality of Health CareRetrospective StudiesSubacute CareConceptsED visitsReadmission ratesTotal hipPostdischarge experiencesHospital-based acute carePostdischarge health care utilizationHospital emergency department (ED) visitsAcute care measuresEmergency department visitsED visit ratesHospital readmission ratesHealth care utilizationDepartment visitsHospital readmissionCare utilizationAcute careKnee arthroplastyCare measuresVisit ratesVisitsReadmissionArthroplastyHospitalHipCarePredictors and outcomes of unplanned readmission to a different hospital
Kim H, Hung WW, Paik MC, Ross JS, Zhao Z, Kim GS, Boockvar K. Predictors and outcomes of unplanned readmission to a different hospital. International Journal For Quality In Health Care 2015, 27: 513-519. PMID: 26472739, PMCID: PMC4665363, DOI: 10.1093/intqhc/mzv082.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCaliforniaData Interpretation, StatisticalDatasets as TopicFemaleForecastingHospitalsHumansMaleMiddle AgedOutcome Assessment, Health CarePatient DischargePatient ReadmissionConceptsDifferent-hospital readmissionsReadmission groupAcute care hospitalsDifferent hospitalsUnplanned readmissionCare hospitalSame hospitalThirty-day unplanned readmissionsPercent of patientsSame-hospital readmissionsBetter care coordinationHospital deathIndex dischargeIndex hospitalCare coordinationHospital costsReadmissionHigher oddsMAIN OUTCOMEPatientsHealth outcomesCost outcomesHospitalSecondary analysisOutcomes
2014
Place of Residence and Outcomes of Patients With Heart Failure
Bikdeli B, Wayda B, Bao H, Ross JS, Xu X, Chaudhry SI, Spertus JA, Bernheim SM, Lindenauer PK, Krumholz HM. Place of Residence and Outcomes of Patients With Heart Failure. Circulation Cardiovascular Quality And Outcomes 2014, 7: 749-756. PMID: 25074375, PMCID: PMC5323058, DOI: 10.1161/circoutcomes.113.000911.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic statusIndividual socioeconomic statusOutcomes of patientsHeart failureHigher SES neighborhoodsSocioeconomic statusClinical factorsHeart Failure Outcomes trialPrimary end pointPatient-level factorsUS internal medicineCause mortalityCause readmissionMultivariable adjustmentOutcome trialsMedical chartsPatient interviewsLow-SES neighborhoodsCardiology practiceMortality ratePatientsPlace of residenceInternal medicineReadmissionEnd pointUsual Source of Care and Outcomes Following Acute Myocardial Infarction
Spatz ES, Sheth SD, Gosch KL, Desai MM, Spertus JA, Krumholz HM, Ross JS. Usual Source of Care and Outcomes Following Acute Myocardial Infarction. Journal Of General Internal Medicine 2014, 29: 862-869. PMID: 24553957, PMCID: PMC4026492, DOI: 10.1007/s11606-014-2794-0.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionUsual sourceMyocardial infarctionMortality rateBaseline risk factorsAcute clinical eventsMain outcome measuresAMI severityAMI patientsMultivariable analysisKey ResultsAmongClinical eventsSocio-demographic characteristicsRisk factorsOutcome measuresReadmissionHigh mortalityPatientsMortalityCareMonthsInfarctionAdultsOutcomesAssociation
2013
Hospital-based, acute care after ambulatory surgery center discharge
Fox JP, Vashi AA, Ross JS, Gross CP. Hospital-based, acute care after ambulatory surgery center discharge. Surgery 2013, 155: 743-753. PMID: 24787100, PMCID: PMC4114736, DOI: 10.1016/j.surg.2013.12.008.Peer-Reviewed Original ResearchMeSH KeywordsAdmitting Department, HospitalAdolescentAdultAgedAged, 80 and overAmbulatory Care FacilitiesAmbulatory Surgical ProceduresCaliforniaEmergency Service, HospitalFemaleFloridaHumansMaleMiddle AgedNebraskaOutcome Assessment, Health CarePatient DischargePatient ReadmissionPatient TransferTime FactorsYoung AdultConceptsAmbulatory surgery centersAcute care ratesHospital transfer ratesTime of dischargeHospital transferSurgery centersAcute careAdult patientsCare ratesAcute care needsRate of needAmbulatory care centersPrimary outcomeCare centerOperative procedureAmbulatory careHealthcare costsCare needsPatientsCenter dischargeUtilization ProjectFirst weekMeasures of qualityCareCenter levelDiagnoses and Timing of 30-Day Readmissions After Hospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia
Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto-Filho JA, Kim N, Bernheim SM, Suter LG, Drye EE, Krumholz HM. Diagnoses and Timing of 30-Day Readmissions After Hospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia. JAMA 2013, 309: 355-363. PMID: 23340637, PMCID: PMC3688083, DOI: 10.1001/jama.2012.216476.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCommon readmission diagnosesAcute MI hospitalizationReadmission diagnosesDays of hospitalizationPatient demographic characteristicsHeart failureMyocardial infarctionHF hospitalizationReadmission timingPneumonia hospitalizationsMedian timeMI hospitalizationMedicare feeIndex HF hospitalizationIndex pneumonia hospitalizationProportion of patientsDemographic characteristicsService claims dataMI cohortPneumonia cohortHF cohortCondition categoriesHospitalizationReadmissionUse of Hospital-Based Acute Care Among Patients Recently Discharged From the Hospital
Vashi AA, Fox JP, Carr BG, D’Onofrio G, Pines JM, Ross JS, Gross CP. Use of Hospital-Based Acute Care Among Patients Recently Discharged From the Hospital. JAMA 2013, 309: 364-371. PMID: 23340638, PMCID: PMC3598620, DOI: 10.1001/jama.2012.216219.Peer-Reviewed Original ResearchConceptsAcute care hospitalsHospital-based acute careAcute care encountersED visitsHospital readmissionAcute careCare hospitalRelease visitsIndex hospitalizationReasons patientsCare encountersED treatUncomplicated benign prostatic hypertrophyUtilization Project State InpatientAcute care visitsDays of dischargeEmergency department visitsCommon reason patientsHospital readmission ratesAcute care servicesBenign prostatic hypertrophyUse of hospitalHealth care focusEffectiveness of transitionCare visits
2012
Coronary Artery Bypass Graft
Hu S, Zheng Z, Yuan X, Wang Y, Normand SL, Ross JS, Krumholz HM. Coronary Artery Bypass Graft. Circulation Cardiovascular Quality And Outcomes 2012, 5: 214-221. PMID: 22396587, PMCID: PMC3509783, DOI: 10.1161/circoutcomes.111.962365.Peer-Reviewed Original ResearchMeSH KeywordsAgedChinaCoronary Artery BypassFemaleHospital MortalityHumansMaleMiddle AgedOutcome Assessment, Health CareConceptsChinese Cardiac Surgery RegistryCardiac Surgery RegistryCABG surgeryComplication rateCoronary artery bypass graftCoronary artery bypassMajor complication rateArtery bypass graftCause mortality ratesNational multicenter databaseHospital-level performanceArtery bypassHospital mortalityMediastinal infectionRenal failureConsecutive patientsBypass graftMulticenter databaseMean ageMyocardial infarctionNational registryCABG facilitiesMortality rateSurgeryHospital
2011
Expanding the Frontier of Outcomes Measurement for Public Reporting
Ross JS, Bernheim SM, Drye ED. Expanding the Frontier of Outcomes Measurement for Public Reporting. Circulation Cardiovascular Quality And Outcomes 2011, 4: 11-13. PMID: 21245460, PMCID: PMC3046632, DOI: 10.1161/circoutcomes.110.959908.Commentaries, Editorials and Letters
2010
Beyond insurance coverage: Usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey
Spatz ES, Ross JS, Desai MM, Canavan ME, Krumholz HM. Beyond insurance coverage: Usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey. American Heart Journal 2010, 160: 115-121. PMID: 20598981, PMCID: PMC3025407, DOI: 10.1016/j.ahj.2010.04.013.Peer-Reviewed Original ResearchConceptsTreatment of hypertensionNutrition Examination SurveyInsurance statusMedication treatmentExamination SurveyNational HealthUsual sourceAdult Treatment Panel III recommendationsJoint National Committee 7Multivariable logistic regression modelingInsurance coverageSeparate multivariable modelsChronic disease managementLogistic regression modelingHigh-quality careRace/ethnicityCardiovascular diseaseMultivariable modelStratified analysisHypertensionHypercholesterolemiaRegular sourceCareDisease managementIndependent effectsDifferences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization
Chen J, Krumholz HM, Wang Y, Curtis JP, Rathore SS, Ross JS, Normand SL, Schreiner GC, Mulvey G, Nallamothu BK. Differences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention: Implications for Regionalization. JAMA Internal Medicine 2010, 170: 433-439. PMID: 20212179, PMCID: PMC2900156, DOI: 10.1001/archinternmed.2009.538.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryFemaleHospitalsHumansMaleMyocardial InfarctionOutcome Assessment, Health CareRegistriesSurvival AnalysisSurvival RateTreatment OutcomeUnited StatesConceptsRisk-standardized mortality ratesNon-PCI hospitalsPercutaneous coronary interventionAcute myocardial infarctionHospital referral regionsPCI hospitalsHealth care regionCoronary interventionAMI patientsMyocardial infarctionCare regionLower risk-standardized mortality ratesSame hospital referral regionService beneficiaries 65 yearsBeneficiaries 65 yearsMagnitude of benefitPatient survivalAMI careReferral regionsOutcome differencesMedicare feeMortality rateHospitalHospital capabilitiesInfarction
2008
An Administrative Claims Measure Suitable for Profiling Hospital Performance on the Basis of 30-Day All-Cause Readmission Rates Among Patients With Heart Failure
Keenan PS, Normand SL, Lin Z, Drye EE, Bhat KR, Ross JS, Schuur JD, Stauffer BD, Bernheim SM, Epstein AJ, Wang Y, Herrin J, Chen J, Federer JJ, Mattera JA, Wang Y, Krumholz HM. An Administrative Claims Measure Suitable for Profiling Hospital Performance on the Basis of 30-Day All-Cause Readmission Rates Among Patients With Heart Failure. Circulation Cardiovascular Quality And Outcomes 2008, 1: 29-37. PMID: 20031785, DOI: 10.1161/circoutcomes.108.802686.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHeart FailureHumansInsurance Claim ReviewMaleMedical RecordsMedicareModels, StatisticalOutcome Assessment, Health CarePatient ReadmissionSoftware ValidationUnited StatesConceptsRisk-standardized readmission ratesCause readmission rateReadmission ratesHeart failureHospital-level readmission ratesAdjusted readmission ratesAdministrative Claims MeasureUnadjusted readmission ratesHeart failure patientsHospital risk-standardized readmission ratesMedical record dataProfiling Hospital PerformanceHierarchical logistic regression modelsUse of MedicareMedical record modelNational Quality ForumLogistic regression modelsCause readmissionClaims-based modelsHospital dischargeFailure patientsC-statisticPreventable eventsPatientsQuality Forum