Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy
Piepmeier J, Pedersen P, Yoshida D, Greer C. Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy. Annals Of Surgical Oncology 1996, 3: 543-549. PMID: 8915486, DOI: 10.1007/bf02306087.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, AlkylatingBrain NeoplasmsCarrier ProteinsCell LineColony-Forming Units AssayEstramustineFlow CytometryGlioblastomaHumansImmunohistochemistryMiceMice, NudeMicrotubule-Associated ProteinsNeoplasm TransplantationRadiation-Sensitizing AgentsThymidineTransplantation, HeterologousTumor Cells, CulturedConceptsSubcutaneous xenograftsGlioblastoma cellsHuman glioblastoma cellsMicrotubule-associated proteinsHuman glioblastomaPotent antimitotic effectsUse of estramustineAntimicrotubule agentsEstramustine-binding proteinPreclinical dataEstramustineNeoplastic cellsAntiproliferative effectsSelective therapyGlioma cellsAntimitotic effectCytotoxic effectsGlioblastomaUseful targetTherapyXenograftsLaboratory investigationsSelective effectAntimitotic activityCellsBEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines.
Jaworski D, Kelly G, Piepmeier J, Hockfield S. BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. Cancer Research 1996, 56: 2293-8. PMID: 8625302.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsBiomarkers, TumorBrain NeoplasmsBrevicanCarrier ProteinsChild, PreschoolChondroitin Sulfate ProteoglycansFemaleGliomaHumansHyaluronic AcidIn Situ HybridizationLectins, C-TypeMaleMiddle AgedNeoplasm InvasivenessNeoplasm ProteinsNeoplasm TransplantationNerve Tissue ProteinsRatsRats, Inbred LewRats, Sprague-DawleyTumor Cells, CulturedConceptsGlioma cell linesSurgical samplesIntracranial graftsCell linesAdult human cortexInvasive glioma cell linesBrain metastasesNonglial tumorsNoninvasive cell linesMalignant gliomasExtracellular brainNormal brainTumor invasionHyaluronan-binding proteinHuman cortexGliomasTumorsInvasive behaviorStandard cell culture conditionsGraftBrainBEHABCell culture conditionsSelective markerMetastasisIn vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor.
Piepmeier J, Rabidou N, Schold S, Bitonti A, Prakash N, Bush T. In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor. Cancer Research 1996, 56: 359-61. PMID: 8542592.Peer-Reviewed Original ResearchConceptsMalignant brain tumorsMedian survivalControl animalsAthymic miceBrain tumorsReductase inhibitorsHuman malignant brain tumorsHuman glioblastomaDays of treatmentSK-N-MCConcentration-dependent inhibitionTumor regressionIntracerebral implantsIntracerebral xenograftsXenograft modelGlioblastoma cell linesVivo inhibitionPotent antiproliferative activityNeuroblastomaGlioblastomaSurvivalCell linesXenograftsNanomolar concentrationsTumors