2008
Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades
Nath AK, Brown RM, Michaud M, Sierra-Honigmann MR, Snyder M, Madri JA. Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. Journal Of Cell Biology 2008, 181: 367-380. PMID: 18411306, PMCID: PMC2315681, DOI: 10.1083/jcb.200708197.Peer-Reviewed Original ResearchConceptsRepertoire of factorsEndocardial cushion formationMouse embryonic heartInterleukin-6 familyEmbryonic developmentCushion formationObserved phenotypeSignal transducerAlphavbeta3 integrin receptorTranscription 3Matrix metalloprotease-2Integrin receptorsMesenchymal transitionAlphavbeta3 integrinEmbryonic heartEMTAbnormal EMTMetalloprotease-2Functional inhibitionAktLoss of leptinPathwayVivo modelReceptorsInhibition
2001
Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion*
Xie B, Zhao J, Kitagawa M, Durbin J, Madri J, Guan J, Fu X. Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion*. Journal Of Biological Chemistry 2001, 276: 19512-19523. PMID: 11278462, DOI: 10.1074/jbc.m009063200.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell AdhesionCell LineCell MovementDNA-Binding ProteinsDose-Response Relationship, DrugEnzyme ActivationFibroblastsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene DeletionGlutathione TransferaseHumansIntegrinsMicroscopy, FluorescenceMutagenesis, Site-DirectedMutationPhosphorylationPlasmidsPrecipitin TestsProtein BindingProtein Structure, TertiaryProtein-Tyrosine KinasesSignal TransductionSTAT1 Transcription FactorSTAT3 Transcription FactorTime FactorsTrans-ActivatorsTransfectionConceptsFocal adhesion kinaseCell adhesionCell migrationFAK-deficient cellsIntegrin/focal adhesion kinaseC-terminal deletionsAdhesion kinaseTerminal domainFAK localizationTranscription pathwayFocal contactsSignal transducerSTAT1PathwayRecent studiesAdhesionMigrationCellsKinaseIntegrinsSTAT3DeletionActivatorFirst timeActivation