1994
Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.
Marx M, Perlmutter R, Madri J. Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis. Journal Of Clinical Investigation 1994, 93: 131-139. PMID: 7506710, PMCID: PMC293745, DOI: 10.1172/jci116936.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsCell DivisionCells, CulturedElectrophoresis, Polyacrylamide GelEndothelium, VascularEpididymisImmunoblottingKineticsMaleMicrocirculationMolecular WeightNeovascularization, PathologicPlatelet-Derived Growth FactorRatsReceptors, Platelet-Derived Growth FactorRecombinant ProteinsTime FactorsConceptsMicrovascular endothelial cellsEndothelial cellsPDGF receptorReceptor expressionPlatelet-derived growth factor receptor expressionGrowth factor receptor expressionPDGF receptor expressionFactor receptor expressionPDGF receptor alphaReceptor surface expressionEndothelial cell growthNovel therapeutic applicationsCell growthSuramin treatmentProliferative responseEndothelial cell phenotypeReceptor alphaPDGF isoformsPDGF-AAInhibited proliferationReceptor regulationPDGF-BBPDGF-ABAngiogenesisCell proliferation
1993
Functional CD4 T cell subset interplay in an intact immune system.
Murray J, Madri J, Pasqualini T, Bottomly K. Functional CD4 T cell subset interplay in an intact immune system. The Journal Of Immunology 1993, 150: 4270-6. PMID: 8097751, DOI: 10.4049/jimmunol.150.10.4270.Peer-Reviewed Original ResearchConceptsCD4 T cellsTh-2 cellsT cellsIL-5Antibody formationIFN-gammaTh-2-like cellsF1 hybrid T cellsIntact immune systemTh-1 cellsGood proliferative responsesCollagen IVCell primingProliferative responseImmune systemTh-1Hybrid miceMiceGamma treatmentAdditional studiesHuman collagen IVImmunizationSelective activationVivoCells
1991
Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV
Pfeiffer C, Murray J, Madri J, Bottomly K. Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV. Immunological Reviews 1991, 123: 65-84. PMID: 1684784, DOI: 10.1111/j.1600-065x.1991.tb00606.x.Peer-Reviewed Original ResearchConceptsT cell proliferative responsesTh2 responsesProliferative responseTh2 cellsT cellsT cell IL-4Collagen IVClass of immunityMHC class II moleculesT cell responsesActivation of Th1IFN-gamma releaseClass II MHC moleculesIL-5 releaseTypes of CD4Th2-like cellsClass II genotypesClass II moleculesMHC class II genotypeII MHC moleculesType of responseT cell ligandsMHC genotypeTh1 responseGamma release
1989
MHC control of CD4+ T cell subset activation.
Murray J, Madri J, Tite J, Carding S, Bottomly K. MHC control of CD4+ T cell subset activation. Journal Of Experimental Medicine 1989, 170: 2135-2140. PMID: 2573684, PMCID: PMC2189542, DOI: 10.1084/jem.170.6.2135.Peer-Reviewed Original ResearchConceptsT cellsIL-2IL-4-producing CD4T cell subset activationIL-4-producing cellsI-Ab miceMHC class II haplotypesCytokine-producing CD4T-cell phenotypeTypes of CD4Secondary IgG responsesClass II MHCSelective activationClass II haplotypesMHC controlSuch selective activationCytokine phenotypeIgG responsesSubset activationII MHCImmune responseProliferative responseCD4Vivo responseMice
1987
Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.
Tite J, Foellmer H, Madri J, Janeway C. Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen. The Journal Of Immunology 1987, 139: 2892-8. PMID: 3117879, DOI: 10.4049/jimmunol.139.9.2892.Peer-Reviewed Original ResearchConceptsT cell proliferative responsesCell proliferative responsesAntibody responseIr gene controlProliferative responseT cellsHigher antibody responseClass II MHCMHC congenic miceMajor histocompatibility complexImmunologic responsivenessResponder parentF1 miceII MHCDifferent MHC genotypesImmune responseType IV collagenCongenic miceMiceHistocompatibility complexIV collagenDifferential activationAntigenBasement membrane collagenMHC genotype