1989
MHC control of CD4+ T cell subset activation.
Murray J, Madri J, Tite J, Carding S, Bottomly K. MHC control of CD4+ T cell subset activation. Journal Of Experimental Medicine 1989, 170: 2135-2140. PMID: 2573684, PMCID: PMC2189542, DOI: 10.1084/jem.170.6.2135.Peer-Reviewed Original ResearchConceptsT cellsIL-2IL-4-producing CD4T cell subset activationIL-4-producing cellsI-Ab miceMHC class II haplotypesCytokine-producing CD4T-cell phenotypeTypes of CD4Secondary IgG responsesClass II MHCSelective activationClass II haplotypesMHC controlSuch selective activationCytokine phenotypeIgG responsesSubset activationII MHCImmune responseProliferative responseCD4Vivo responseMice
1987
Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.
Tite J, Foellmer H, Madri J, Janeway C. Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen. The Journal Of Immunology 1987, 139: 2892-8. PMID: 3117879, DOI: 10.4049/jimmunol.139.9.2892.Peer-Reviewed Original ResearchConceptsT cell proliferative responsesCell proliferative responsesAntibody responseIr gene controlProliferative responseT cellsHigher antibody responseClass II MHCMHC congenic miceMajor histocompatibility complexImmunologic responsivenessResponder parentF1 miceII MHCDifferent MHC genotypesImmune responseType IV collagenCongenic miceMiceHistocompatibility complexIV collagenDifferential activationAntigenBasement membrane collagenMHC genotype