1997
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. Journal Of Clinical Investigation 1997, 100: 3131-3139. PMID: 9399960, PMCID: PMC508526, DOI: 10.1172/jci119868.Peer-Reviewed Original ResearchConceptsHuman umbilical vein endothelial cellsVascular endothelial growth factorPhosphoinositide-3 kinase inhibitorDimensional collagen gelsRegulator of vasculogenesisKinase inhibitorsGrowth of HUVECsGrowth factorExposure of cellsUmbilical vein endothelial cellsEndothelial cellsTyrosine kinaseHuman endothelial cellsVEGF stimulationSynthase proteinK kinaseEndothelial growth factorVein endothelial cellsProtein levelsEC proliferationKinaseHuman ECsDependent formationNO-dependent mannerShort-term stimulation
1989
Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells.
Bell L, Madri J. Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circulation Research 1989, 65: 1057-1065. PMID: 2791219, DOI: 10.1161/01.res.65.4.1057.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsPlatelet-derived growth factorSMC proliferationPlatelet factorEC proliferationMuscle cellsGrowth factorEndothelial cell injuryMechanism of actionVascular injuryVascular diseaseCell injurySMC migrationBovine aortic ECsAortic ECsInjuryNorepinephrineProliferationHistaminePresent studyResponse of ECPhenoxybenzamineKetanserinCellsAtherosclerosis