2013
Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult
Li Q, Canosa S, Flynn K, Michaud M, Krauthammer M, Madri JA. Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult. PLOS ONE 2013, 8: e76265. PMID: 24146847, PMCID: PMC3795763, DOI: 10.1371/journal.pone.0076265.Peer-Reviewed Original ResearchConceptsSubventricular zoneRepair/recoveryChronic hypoxiaPremature infant populationMurine subventricular zoneEarly intervention approachesNeurodevelopmental handicapPremature infantsNeurovascular nicheHypoxic insultCD1 miceInfant populationMotor responsivenessCNS tissueDisease severityMRNA expressionUnbiased transcriptome analysisDifferent behavioral parametersNeural functionMouse strainsDifferential responseHypoxiaHypoxic conditionsRange of responsivenessIntervention approaches
2008
Determining the molecular mechanisms of vascular sympathetic innervation
Long J, Segal S, Madri J. Determining the molecular mechanisms of vascular sympathetic innervation. The FASEB Journal 2008, 22: 169.1-169.1. DOI: 10.1096/fasebj.22.1_supplement.169.1.Peer-Reviewed Original ResearchSuperior cervical ganglionSympathetic innervationTyrosine hydroxylase stainingVascular sympathetic innervationReceptor neuropilin-1Axon guidance moleculesSCG explantsSympathetic nervesBlood pressureCervical ganglionVascular innervationCardiac outputPeripheral vasoconstrictionSympathetic neuronsCD1 miceCarotid arteryAdult innervationArtery increasesInnervationNeuropilin-2Neuropilin-1Guidance moleculesQRT-PCRArteryNeurite outgrowth