Dependence on pH of polarized sorting of secreted proteins
Caplan M, Stow J, Newman A, Madri J, Anderson H, Farquhar M, Palade G, Jamieson J. Dependence on pH of polarized sorting of secreted proteins. Nature 1987, 329: 632-635. PMID: 2821405, DOI: 10.1038/329632a0.Peer-Reviewed Original ResearchConceptsSecretory proteinsMDCK cellsDifferent protein compositionsBasolateral cell surfacePolarized sortingMembrane proteinsBasolateral domainDefault pathwayPlasma membraneAcidic intracellular compartmentsIntracellular compartmentsProtein compositionMembrane componentsCell surfaceBasement membrane componentsProteinSecrete lamininDistinct setsRenal tubule cellsEpithelial cellsActive sortingBasolateral compartmentCellsSecretory productsSpecific regionsThe Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue
Buchanan M, Richardson M, Haas T, Hirsh J, Madri J. The Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue. Thrombosis And Haemostasis 1987, 58: 698-704. PMID: 3672420, DOI: 10.1055/s-0038-1645958.Peer-Reviewed Original ResearchConceptsEndothelial cellsPlatelet accumulationAir perfusionBalloon catheter injuryBasement membraneRabbit carotid arteryCatheter strippingCatheter injuryPerfusion injuryHuman endothelial cellsPlatelet reactivityInteraction of plateletsCarotid arteryElectron microscopic examinationVascular endotheliumTransmission electron microscopic examinationPlatelet adhesionCollagen type IInjuryOne hourConflicting resultsMicroscopic examinationSubendotheliumBasement membrane componentsVivo