2015
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseVascular calcificationArterial calcificationOrphan diseaseCommon diseaseSequelae of diseaseEctopic vascular calcificationInternal elastic laminaPrevent mortalityRenal failureCardiac failureKidney diseaseSubcutaneous administrationRodent modelsAnimal modelsEctopic calcificationVascular wallLarge arteriesElastic laminaDiseaseCalcificationCalciphylaxisDecreased concentrationSclerosisArtery
2008
Determining the molecular mechanisms of vascular sympathetic innervation
Long J, Segal S, Madri J. Determining the molecular mechanisms of vascular sympathetic innervation. The FASEB Journal 2008, 22: 169.1-169.1. DOI: 10.1096/fasebj.22.1_supplement.169.1.Peer-Reviewed Original ResearchSuperior cervical ganglionSympathetic innervationTyrosine hydroxylase stainingVascular sympathetic innervationReceptor neuropilin-1Axon guidance moleculesSCG explantsSympathetic nervesBlood pressureCervical ganglionVascular innervationCardiac outputPeripheral vasoconstrictionSympathetic neuronsCD1 miceCarotid arteryAdult innervationArtery increasesInnervationNeuropilin-2Neuropilin-1Guidance moleculesQRT-PCRArteryNeurite outgrowth